Listar por autor "García Lescano, Héctor Hugo"

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Addressing geographical variation in the progression of non-communicable diseases in Peru: The CRONICAS cohort study protocol

Miranda, J. Jaime; Bernabé Ortiz, Antonio; Smeeth, L.; Gilman, Robert Hugh; Checkley, W.; Casas, J.P.; Smith, G.D.; Ebrahim, S.; Gamboa, Raúl; García Lescano, Héctor Hugo; Huicho Oriundo, Luis; Málaga Rodríguez, Germán Javier; Montori, V.M.; Diette, G.B.; León-Velarde, Fabiola; Rivera, Maria; Wise, R.A.; Sacksteder, K. (BMJ Publishing Group, 2012)

Background: The rise in non-communicable diseases in developing countries has gained increased attention. Given that around 80% of deaths related to noncommunicable diseases occur in low- and middleincome countries, there ...
Addressing post-stroke care in rural areas with Peru as a case study. Placing emphasis on evidence-based pragmatism

Miranda, J. Jaime; Moscoso, Miguel G.; Yan, Lijing L.; Diez-Canseco Montero, Francisco; Málaga Rodríguez, Germán Javier; García Lescano, Héctor Hugo; Ovbiagele, Bruce (Elsevier, 2017)

Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local ...
Advances in the treatment, diagnosis, control and scientific understanding of taeniid cestode parasite infections over the past 50 years

Lightowlers, Marshall W.; Gasser, Robin B.; Hemphill, Andrew; Romig, Thomas; Tamarozzi, Francesca; Deplazes, Peter; Torgerson, Paul R.; García Lescano, Héctor Hugo; Kern, Peter (Elsevier, 2021)

In the past 50 years, enormous progress has been made in the diagnosis, treatment and control of taeniid cestode infections/diseases and in the scientific understanding thereof. Most interest in this group of parasites ...
Albendazole sulfoxide plasma levels and efficacy of antiparasitic treatment in patients with parenchymal neurocysticercosis

Arroyo Hurtado, Gianfranco; Bustos Palomino, Javier Arturo; Lescano Guevara, Andres Guillermo; Gonzales, Isidro; Saavedra Pastor, Herbert; Rodriguez, Silvia; Pretell, E. Javier; Bonato, Pierina S.; Lanchote, Vera L.; Takayanagui, Osvaldo M.; Horton, John; Gonzalez Zariquiey, Armando Emiliano; Gilman, Robert Hugh; García Lescano, Héctor Hugo (Oxford University Press, 2019)

Background: The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable ...
Anti-Taenia solium monoclonal antibodies for the detection of parasite antigens in body fluids from patients with neurocysticercosis

Paredes, Adriana; Saenz, Patricia; Marzal, Miguel-W.; Orrego Solano, Miguel Ángel; Castillo Berrios, Yesenia; Rivera, Andrea; Mahanty, Siddhartha; Guerra-Giraldez, Cristina; García Lescano, Héctor Hugo; Nash, Theodore-E. (Elsevier, 2016)

Neurocysticercosis (NCC), an infection of the brain by Taenia solium (Ts) cysts, is the most common cause of adult-onset epilepsy in developing countries. Serological testing consists primarily of varying methods to detect ...
Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with Neurocysticercosis

Arroyo Hurtado, Gianfranco; Rodriguez, Silvia; Lescano Guevara, Andres Guillermo; Alroy, Karen A.; Bustos Palomino, Javier Arturo; Santivañez, Saul; Gonzales, Isidro; Saavedra Pastor, Herbert; Pretell, E. Javier; Gonzalez Zariquiey, Armando Emiliano; Gilman, Robert Hugh; Tsang, Victor C. W.; García Lescano, Héctor Hugo; Cysticercosis Working Group in Peru (Oxford University Press, 2018)

Background: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections ...
Antiepileptic drug therapy and recommendations for withdrawal in patients with seizures and epilepsy due to neurocysticercosis

Bustos Palomino, Javier Arturo; García Lescano, Héctor Hugo; Del-Brutto, Oscar-H. (Taylor and Francis, 2016)

INTRODUCTION: Neurocysticercosis (NCC) is a leading causes of secondary epilepsy worldwide. There is increasing evidence on the epileptogenic role of NCC, and the presence of edema, calcified scars, gliosis and hippocampal ...
Antiparasitic treatment of neurocysticercosis - The effect of cyst destruction in seizure evolution

García Lescano, Héctor Hugo; Del Brutto, Oscar H. (Elsevier, 2017)

Antiparasitic agents against Taenia solium cysticercosis have been in use since 1979, although its use has been questioned on the basis that cysts would die naturally and thus treatment-induced inflammation is unnecessary. ...
Apuntes y recomendaciones para el establecimiento de programas de control de la teniasis / cisticercosis por Taenia solium en el Perú

García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano; O'Neal, Seth E.; Gilman, Robert Hugh (Instituto Nacional de Salud, 2018)

Neurocysticercosis is the infection of the nervous system by the larvae (cysticerci) of the pork tapeworm Taenia solium. Neurocysticercosis is the major cause of acquired epilepsy worldwide and as such, it represents a ...
Assembly and phylogeographical analysis of novel Taenia solium mitochondrial genomes suggest stratification within the African-American genotype

Jiménez Avalos, Gabriel Mateo; Soto Obando, Alina; Solis, Maria; Gilman, Robert H.; Cama, Vitaliano; Gonzalez, Armando E.; García Lescano, Héctor Hugo; Sheen Cortavarria, Patricia; Requena, David; Zimic-Peralta, Mirko Juan (BioMed Central, 2023)

Background: Taenia solium is a parasite of public health concern, causing human taeniasis and cysticercosis. Two main genotypes have been identified: Asian and African-American. Although characterizing T. solium genotypes ...
Assessing Ultrasonography as a Diagnostic Tool for Porcine Cysticercosis

Flecker, Robert H.; Pray, Ian W.; Santivanez, Saul J.; Ayvar, Viterbo; Gamboa Morán, Ricardo; Muro Ecca, Claudio Alberto; Moyano, Luz Maria; Benavides, Victor; García Lescano, Héctor Hugo; O'Neal, Seth E. (Public Library of Science, 2017)

BACKGROUND: Taenia solium inflicts substantial neurologic disease and economic losses on rural communities in many developing nations. "Ring-strategy" is a control intervention that targets treatment of humans and pigs ...
The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age

Del Brutto, Oscar H.; Issa, Naoum P.; Salgado, Perla; Del Brutto, Victor J.; Zambrano, Mauricio; Lama, Julio; García Lescano, Héctor Hugo (American Society of Tropical Medicine and Hygiene, 2017)

Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case-control study design, residents ...
Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis

Mejia Maza, Alan J.; Carmen-Orozco, Rogger P.; Carter, Emma; Dávila, Danitza G.; Castillo Vilca, Gino; Morales, Jemina D.; Mamani, Javier; Gavídia, Cesar; Alroy, Joseph; Sterling, Charles R.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; Woltjer, Randy L.; Verastegui Pimentel, Manuela Renee; Gilman, Robert Hugh; Cysticercosis Working Group in Peru (Wiley, 2018)

Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of the Taenia solium and is the leading cause of preventable epilepsy world-wide. However, the pathophysiology and relation ...
Barriers to participation in a community-based program to control transmission of Taenia solium in Peru

Beam, Michelle; Spencer, Angela; Fernandez, Lauralee; Atto, Ruth; Muro Ecca, Claudio Alberto; Vilchez Barreto, Percy Mcquen; Gamboa Morán, Ricardo; Olaya, Sandra; Ayvar, Viterbo; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; O'Neal, Seth E.; Cysticercosis Working Group in Peru (American Society of Tropical Medicine and Hygiene, 2018)

Infection of the brain with Taenia solium larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities ...
Blood-brain barrier disruption and angiogenesis in a rat model for neurocysticercosis

Carmen-Orozco, Rogger P.; Dávila-Villacorta, Danitza G.; Cauna, Yudith; Bernal-Teran, Edson G.; Bitterfeld, Leandra; Sutherland, Graham L.; Chile Andrade, Nancy; Céliz, Rensson H.; Ferrufino-Schmidt, María C.; Gavídia, Cesar M.; Sterling, Charles R.; García Lescano, Héctor Hugo; Gilman, Robert Hugh; Verastegui Pimentel, Manuela Renee (Wiley, 2018)

Neurocysticercosis (NCC) is a helminth infection affecting the central nervous system caused by the larval stage (cysticercus) of Taenia solium. Since vascular alteration and blood-brain barrier (BBB) disruption contribute ...
Building a platform for translational research in chronic noncommunicable diseases to address population health: lessons from NHLBI supported CRONICAS in Peru

Miranda, J. Jaime; Bernabé Ortiz, Antonio; Diez-Canseco Montero, Francisco; Málaga Rodríguez, Germán Javier; Cárdenas García-Santillán, María Kathia; Carrillo Larco, Rodrigo Martín; Pesantes Villa, María Amalia; Araya, Ricardo; Boggio, Oscar; Checkley, William; Garcia Funegra, Patricia Jannet; León-Velarde, Fabiola; Lescano Guevara, Andres Guillermo; Montori, Victor; Pan, William; Rivera Chira, Maria Concepcion; Sacksteder, Katherine; Smeeth, Liam; García Lescano, Héctor Hugo; Gilman, Robert Hugh (Elsevier, 2015)

The CRONICAS Centre of Excellence in Chronic Diseases, based at Universidad Peruana Cayetano Heredia, was created in 2009 with support from the U.S. National Heart, Lung, and Blood Institute (NHLBI). The vision of CRONICAS ...
Calcified neurocysticercosis associates with hippocampal atrophy: a population-based study

Del Brutto, Oscar H.; Salgado, Perla; Lama, Julio; Del Brutto, Victor J.; Campos, Xavier; Zambrano, Mauricio; García Lescano, Héctor Hugo (American Society of Tropical Medicine and Hygiene, 2015)

Calcified neurocysticercosis has been associated with hippocampal atrophy in patients with refractory epilepsy, but the relevance of this association in the population at large is unknown. We assessed calcified cysticerci ...
Caracterización celular, molecular y metabólica de la pared quística del cisticerco racemoso de Taenia solium

Orrego Solano, Miguel Angel (Universidad Peruana Cayetano HerediaPE, 2022)

La neurocisticercosis racemosa es una enfermedad agresiva causada por la expansión y proliferación aberrante de la membrana del quiste de Taenia solium dentro del espacio subaracnoideo del cerebro humano causando un efecto ...
Carotid Taenia solium oncosphere infection: a novel porcine neurocysticercosis model

Alroy, Karen A.; Arroyo Hurtado, Gianfranco; Gilman, Robert Hugh; Gonzales-Gustavson, Eloy; Gallegos, Linda; Gavidia, Cesar M.; Verastegui Pimentel, Manuela Renee; Rodriguez, Silvia; Lopez, Teresa; Gomez-Puerta, Luis A.; Alroy, Joseph; García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano; Cysticercosis Working Group in Peru (American Society of Tropical Medicine and Hygiene, 2018)

Neurocysticercosis (NCC), the infection of the human central nervous system (CNS) with larval cysts of Taenia solium causes widespread neurological morbidity. Animal models are crucial for studying the pathophysiology and ...
Case 15-2012: Diplopia, headaches, and papilledema

García Lescano, Héctor Hugo; Rodriguez, S.; Dorny, P. (Massachusetts Medical Society, 2012)

Neurocysticercosis is endemic in most of the world, and it accounts for 2% of seizure cases in some areas of the United States.1 Extraparenchymal neurocysticercosis, discussed in the Case Record involving a patient with ...