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Browsing by Author "Haddad, Gabriel G."

Browsing by Author "Haddad, Gabriel G."

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  • Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with Chronic Mountain Sickness. 
    Bermudez, Daniela; Azad, Priti; Figueroa-Mujica, Romulo; Vizcardo-Galindo, Gustavo; Corante, Noemi; Guerra-Giraldez, Cristina; Haddad, Gabriel G.; Villafuerte, Francisco C. (American Physiological Society, 2019)
    Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE ...
  • Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B 
    Azad, Priti; Zhou, Dan; Tu, Hung-Chi; Villafuerte Castrillón, Francisco Carlos; Traver, David; Rana, Tariq M.; Haddad, Gabriel G. (American Society for Clinical Investigation, 2023)
    Excessive Erythrocytosis (EE) is a major hallmark of patients suffering from chronic mountain sickness (CMS, Monge's disease) and is responsible for major morbidity and even mortality in early adulthood. We took advantage ...
  • New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude 
    Stobdan, Tsering; Akbari, Ali; Azad, Priti; Zhou, Dan; Poulsen, Orit; Appenzeller, Otto; Gonzales Rengifo, Gustavo Francisco; Telenti, Amalio; Wong, Emily H. M.; Saini, Shubham; Kirkness, Ewen F.; Venter, J. Craig; Bafna, Vineet; Haddad, Gabriel G. (Oxford University Press, 2017)
    Human high-altitude (HA) adaptation or mal-adaptation is explored to understand the physiology, pathophysiology, and molecular mechanisms that underlie long-term exposure to hypoxia. Here, we report the results of an ...
  • Protective role of estrogen against excessive erythrocytosis in Monge's disease 
    Azad, Priti; Villafuerte, Francisco C.; Bermudez, Daniela; Patel, Gargi; Haddad, Gabriel G. (Springer Nature, 2021)
    Monge's disease (chronic mountain sickness (CMS)) is a maladaptive condition caused by chronic (years) exposure to high-altitude hypoxia. One of the defining features of CMS is excessive erythrocytosis with extremely high ...
  • Whole-Genome sequencing uncovers the genetic basis of chronic mountain sickness in andean highlanders 
    Zhou, Dan; Udpa, Nitin; Ronen, Roy; Stobdan, Tsering; Liang, Junbin; Appenzeller, Otto; Zhao, Huiwen W.; Yin, Yi; Du, Yuanping; Guo, Lixia; Cao, Rui.; Wang, Yu; Jin, Xin; Huang, Chen; Jia, Wenlong; Cao, Dandan; Guo, Guangwu; Gamboa, Jorge L.; Villafuerte, Francisco C.; Callacondo, David; Xue, Jin; Liu, Siqi; Frazer, Kelly A.; Li, Yingrui; Bafna, Vineet; Haddad, Gabriel G. (Elsevier, 2013)
    The hypoxic conditions at high altitudes present a challenge for survival, causing pressure for adaptation. Interestingly, many highaltitude denizens (particularly in the Andes) are maladapted, with a condition known as ...

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