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Molecular specific and sensitive detection of pyrazinamide and its metabolite pyrazinoic acid by means of surface enhanced raman spectroscopy employing in situ prepared colloids

Muehlig, A.; Jahn, I.J.; Heidler, J.; Jahn, M.; Weber, K.; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan; Cialla-May, D.; Popp, J. (MDPI, 2019)

The prodrug pyrazinamide (PZA) is metabolized by the mycobacteria to pyrazinoic acid (POA), which is expelled into the extracellular environment. PZA resistance is highly associated to a lack of POA efflux. Thus, by detecting ...