Listar por autor "Sheen Cortavarria, Patricia"

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Actinobacteria isolated from mineral ores in Peru

Hurtado Custodio, Jasmin Elena; Pacheco, S.L.; Sheen Cortavarria, Patricia; Ugarte, D. (Faculty of Biotechnology and Food Sciences in Nitra, 2018)

A total of twenty-four isolates of actinobacteria from arsenopyrite, pyrite, polymetallic sulfides and magnetite from Peruvian mining zones have been used with the purpose of characterizing them by morphological, physiological ...
Alternative cost-effective media to facilitate MODS culture for diagnostics of tuberculosis

Sheen Cortavarria, Patricia; Rodriguez, Joseline; Alcantara, Roberto; Vargas, Johnny; Grandjean, Louis; Moore, David Alexander James; Gilman, Robert Hugh; Zimic-Peralta, Mirko Juan (Elsevier, 2022)

Most culture-based methods for tuberculosis diagnosis remain low-cost options for low- and mid-income countries. The MODS culture is a rapid and low-cost assay to diagnose tuberculosis and determine drug susceptibility. ...
Análisis de la expresión de genes con mutaciones compensatorias a mutaciones en rpoB en cepas de Mycobacterium tuberculosis resistentes a rifampicina

Toledo Cornejo, Angie Katiushka (Universidad Peruana Cayetano HerediaPE, 2017)

La rifampicina (RIF) es uno de los medicamentos más importantes en el tratamiento de primera línea de tuberculosis (TB) y su mecanismo de acción consiste en unirse a la subunidad beta de la ARN polimerasa (codificada por ...
Assembly and phylogeographical analysis of novel Taenia solium mitochondrial genomes suggest stratification within the African-American genotype

Jiménez Avalos, Gabriel Mateo; Soto Obando, Alina; Solis, Maria; Gilman, Robert H.; Cama, Vitaliano; Gonzalez, Armando E.; García Lescano, Héctor Hugo; Sheen Cortavarria, Patricia; Requena, David; Zimic-Peralta, Mirko Juan (BioMed Central, 2023)

Background: Taenia solium is a parasite of public health concern, causing human taeniasis and cysticercosis. Two main genotypes have been identified: Asian and African-American. Although characterizing T. solium genotypes ...
The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru

Grandjean, Louis; Iwamoto, Tomotada; Lithgow, Anna; Gilman, Robert Hugh; Arikawa, Kentaro; Nakanishi, Noriko; Martin, Laura; Castillo, Edith; Alarcon, Valentina; Coronel, Jorge; Solano, Walter; Aminian, Minoo; Guezala, Claudia; Rastogi, Nalin; Couvin, David; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan; Moore, David Alexander James (Public Library of Science, 2015)

BACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of ...
Automatic diagnostics of tuberculosis using convolutional neural networks analysis of MODS digital images

Lopez-Garnier, Santiago; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Public Library of Science, 2019)

Tuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility ...
Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi

Lopez, Juan M.; Antiparra, Ricardo; Lippens, Guy; Zimic-Peralta, Mirko Juan; Sheen Cortavarria, Patricia; Maruenda, Helena (Springer, 2018)

Chagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator ...
Biorecognition and detection of antigens from Mycobacterium tuberculosis using a sandwich ELISA associated with magnetic nanoparticles

León-Janampa, N.; Shinkaruk, S.; Gilman, Robert Hugh; Kirwan, D.E.; Fouquet, E.; Szlosek, M.; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Elsevier, 2022)

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is one of the 10 leading causes of death worldwide, especially in low-income areas. A rapid, low-cost diagnostic assay for TB with high sensitivity and specificity ...
Cepa aislada de streptomyces sp. y su uso en la rehabilitación de suelos contaminados con mercurio Y COMO FUENTE DE COMPUESTOS ANTI-CANCERÍGENOS

Hurtado Custodio De Berastain, Jazmín Elena; Pacheco Huerta, Sara Luz; Sheen Cortavarria, Patricia (Instituto Nacional de Defensa de la Competencia y de la Protección de la Propiedad IntelectualPE, 2020-03-11)

Se refiere a cuatro cepas de bacterias del género Streptomyces aisladas de minerales y concentrados de minas de los andes peruanos, las cuales han sido codificadas como cepas AB5, F, K1A y C2; y procesos de biorremediación ...
Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis

Leon-Janampa, Nancy; Liendo, Ruddy; Gilman, Robert Hugh; Padilla, Carlos; García Lescano, Héctor Hugo; Gonzales, Armando; Sheen Cortavarria, Patricia; Pajuelo Travezaño, Monica Jhenny; Zimic-Peralta, Mirko Juan; Cysticercosis Working Group in Peru (Elsevier, 2019)

Porcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, ...
Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M-PRO

Jimenez-Avalos, Gabriel; Paula Vargas-Ruiz, A.; Delgado-Pease, Nicolas E.; Olivos-Ramirez, Gustavo E.; Sheen Cortavarria, Patricia; Fernandez-Diaz, Manolo; Quiliano, Miguel; Zimic-Peralta, Mirko Juan; COVID-19 Working Grp Peru (Springer Nature, 2021)

SARS-CoV-2 main protease is a common target for inhibition assays due to its high conservation among coronaviruses. Since flavonoids show antiviral activity, several in silico works have proposed them as potential SARS-CoV-2 ...
Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection

Dudley, Matthew Z.; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Ticona, Eduardo; Friedland, Jon S.; Kirwan, Daniela E.; Caviedes, Luz; Rodriguez, Richard; Cabrera, Lilia Z.; Coronel, Jorge; Grandjean, Louis; Moore, David Alexander James; Evans, Carlton Anthony William; Huaroto, Luz; Chavez-Perez, Victor; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2016)

Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)–positive patients, as these patients are at heightened risk of developing ...
Determination of potentially novel compensatory mutations in rpoC associated with rifampin resistance and rpoB mutations in Mycobacterium tuberculosis Clinical isolates from Peru

Vargas Ruiz, Ana Paula; Rios, A.; Grandjean, Louis; Kirwan, D.; Gilman, Robert Hugh; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Medknow Publications, 2020)

Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations ...
Development of an automated MODS plate reader to detect early growth of Mycobacterium tuberculosis

Comina, G.; Mendoza, D.; Velazco, A.; Coronel, J.; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Moore, David Alexander James; Zimic-Peralta, Mirko Juan (Wiley, 2011)

In this work, an automated microscopic observation drug susceptibility (MODS) plate reader has been developed. The reader automatically handles MODS plates and after autofocussing digital images are acquired of the ...
Direct determination of pyrazinamide (PZA) susceptibility by sputum microscopic observation drug susceptibility (MODS) culture at neutral pH: the MODS-PZA assay

Alcántara, Roberto; Fuentes, Patricia; Marin, Lisette; Kirwan, Daniela E.; Gilman, Robert Hugh; Zimic-Peralta, Mirko Juan; Sheen Cortavarria, Patricia (American Society for Microbiology, 2020)

Pyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is ...
Diseño bioinformático de un antígeno multi-epítope para la detección de la fase aguda de Toxoplasma gondii utilizando GRA7 y GRA8

Rodriguez Gonzales, Sebastian; Velasquez Humala, Valeria Shantall (Universidad Peruana Cayetano HerediaPE, 2024)

Toxoplasma gondii, un parásito intracelular oportunista, puede provocar enfermedades graves e incluso letales en pacientes inmunosuprimidos o mujeres embarazadas durante la fase aguda de la infección. En consecuencia, se ...
A dot-ELISA using a partially purified cathepsin-L-like protein fraction from Taenia solium cysticerci, for the diagnosis of human neurocysticercosis

Piña, R.; Gutiérrez, A.H.; Gilman, Robert Hugh; Rueda, D.; Sifuentes, C.; Flores, M.; Sheen Cortavarria, Patricia; Rodriguez, S.; García Lescano, Héctor Hugo; Zimic-Peralta, Mirko Juan (Taylor and Francis, 2011)

Human neurocysticercosis (NCC), caused by the cestode Taenia solium, is responsible for a significant amount of neurological morbidity and epilepsy in developing countries. The disease remains highly endemic in many areas, ...
An electrochemical biosensor for the detection of Mycobacterium tuberculosis DNA from sputum and urine samples

Ramos-Sono, D.; Laureano, R.; Rueda, D.; Gilman, Robert Hugh; Rosa, A.L.; Ruiz, Jesús; León, Raúl; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Public Library of Science, 2020)

Tuberculosis (TB) is a major global public health problem with high mortality and morbidity. In low-middle income countries (LMIC) a large number of respiratory symptomatic cases that require TB screening per year demands ...
Estandarización de una PCR multiplex en tiempo real para el diagnóstico de leptospirosis y malaria

Lozano Untiveros, Katherine (Universidad Peruana Cayetano HerediaPE, 2023)

Varias de las enfermedades con etiología infecciosa causada por una variedad de patógenos cursan inicialmente con síndrome febril agudo (SFA) y han sido reconocidos como un grupo importante de enfermedades que es difícil ...
Evaluation of a lens-free imager to facilitate tuberculosis diagnostics in MODS

Solis, Leonardo; Coronel, Jorge; Rueda, Daniel; Gilman, Robert Hugh; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Elsevier, 2015)

Tuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and ...