Listar por autor "Talledo Albujar, Michael John"

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Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy

Moens, B.; Decanine, D.; Menezes, S.M.; Khouri, R.; Silva-Santos, G.; Lopez, G.; Alvarez, C.; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; de Almeida Kruschewsky, R.; Galvão-Castro, B.; Vandamme, A.-M.; van Weyenbergh, J. (Public Library of Science, 2012)

Background: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar ...
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

Menezes, Soraya Maria; Decanine, Daniele; Brassat, David; Khouri, Ricardo; Schnitman, Saul V.; Kruschewsky, Ramon; López, Giovanni; Alvarez, Carolina; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Vandamme, Anne-Mieke; Galvão-Castro, Bernardo; Liblau, Roland; Weyenbergh, Johan Van (BioMed Central, 2014)

Background: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no ...
Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals

Posadas, A. E.; Rosado, J. J.; Gotuzzo Herencia, José Eduardo; Talledo Albujar, Michael John (Elsevier, 2019)

In Peru, it is estimated that about 150,000-400,000 people carry the Human T-lymphotropic virus 1 (HTLV-1). Only 10% of HTLV-1 carries develop complications related to HTLV-1. HTLV-1-associated myelopathy/tropical spastic ...
Determinación de los perfiles de expresión de ARNm de la vía de señalización NF-kB en pacientes con paraparesia espástica tropical y pacientes asintomáticos HTLV-1 positivos

Talledo Albujar, Michael John (Universidad Peruana Cayetano HerediaPE, 2014)

HTLV-1 es un retrovirus que infecta aproximadamente 300,000 personas en el Peru. Este virus se ha asociado a dos enfermedades principales conocidas como mielopatia asociada a HTLV-1 / paraparesia espastica tropical ( HAM/TSP ...
Dynamics of the Magnitude, Breadth and Depth of the Antibody Response at Epitope Level Following Dengue Infection

Falconi-Agapito, F.; Kerkhof, K.; Merino, X.; Michiels, J.; Van Esbroeck, M.; Bartholomeeusen, K.; Talledo Albujar, Michael John; Ariën, K.K. (Frontiers Media, 2021)

Dengue is a major public health problem in tropical and sub-tropical regions worldwide. Since the Zika epidemic and the increased co-circulation of other arboviruses, the serology-based diagnosis of dengue has become more ...
A Fas(hi) Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation

Menezes, Soraya Maria; Leal, Fabio E.; Dierckx, Tim; Khouri, Ricardo; Decanine, Daniele; Silva-Santos, Gilvaneia; Schnitman, Saul V.; Kruschewsky, Ramon; Lopez, Giovanni; Alvarez, Carolina; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Nixon, Douglas F.; Vercauteren, Jurgen; Brassat, David; Liblau, Roland; Vandamme, Anne Mieke; Galvao-Castro, Bernardo; Van Weyenbergh, Johan (Frontiers Media, 2017)

Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals ...
The FAS-670 AA genotype is associated with high proviral load in peruvian HAM/TSP patients

Rosado, Jason; Morales, Sandra; Lopez, Giovanni; Clark, Daniel; Verdonck, Kristien; Gotuzzo Herencia, José Eduardo; Van Camp, Guy; Talledo Albujar, Michael John (Wiley, 2016)

Human T‐lymphotropic virus 1 (HTLV‐1) is the etiologic agent of the HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross‐linking ...
High SARS-CoV-2 Seroprevalence in Rural Peru, 2021: a Cross-Sectional Population-Based Study

Moreira-Soto, Andres; Pachamora Diaz, Johanna Maribel; González-Auza, Lilian; Merino Merino, Xiomara Jeanleny; Schwalb Calderon, Alvaro; Drosten, Christian; Gotuzzo Herencia, José Eduardo; Talledo Albujar, Michael John; Arévalo Ramirez, Heriberto; Peralta Delgado, Roxana; Bocanegra Vargas, Spassky; Drexler, Jan Felix (American Society for Microbiology, 2021)

Latin America has been severely affected by the COVID-19 pandemic. The COVID-19 burden in rural settings in Latin America is unclear. We performed a cross-sectional, population-based, random-selection SARS-CoV-2 serologic ...
Modulación en la expresión de genes de la vía de NF-κB y citoquinas en respuesta al tratamiento con metiltioadenosina en células de pacientes con PET infectados por HTLV-1

Posadas Yábar, Andrés Esteban (Universidad Peruana Cayetano HerediaPE, 2019)

Entre 5 y 10 millones de personas están infectadas con el virus linfotrópico de células T del humano tipo 1 (HTLV-1) en el mundo. En el Perú alrededor de 150 000 a 450 000 personas estarían infectadas con este retrovirus, ...
Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru

Adaui, V.; Maes, I.; Huyse, T.; Van den Broeck, F.; Talledo Albujar, Michael John; Kuhls, K.; De Doncker, S.; Maes, L.; Llanos Cuentas, Elmer Alejandro; Schönian, G.; Arévalo Zelada, Jorge Luis; Dujardin, J.-C. (Elsevier, 2011)

In order to understand the epidemiological dynamics of antimonial (Sb V) resistance in zoonotic tegumentary leishmaniasis and its link with treatment outcome, we analyzed the population structure of 24 Peruvian Leishmania ...
A new genetic variant of dengue serotype 2 virus circulating in the Peruvian Amazon

Falconi-Agapito, Francesca; Selhorst, Philippe; Merino, Xiomara; Torres, Fiorella; Michiels, Johan; Fernandez, Connie; Talledo Albujar, Michael John; Ariën, Kevin K. (Elsevier, 2020)

We sequenced the envelope gene of dengue virus serotype 2 (DENV-2-E) in samples from an outbreak reported in 2018, in Yurimaguas, Peru. The strain belongs to lineage 2 of the American/Asian genotype. We report a variant ...
Peptide Biomarkers for the Diagnosis of Dengue Infection

Falconi-Agapito, Francesca; Kerkhof, Karen; Merino, Xiomara; Bakokimi, Diana; Torres, Fiorella; Van Esbroeck, Marjan; Talledo Albujar, Michael John; Arien, Kevin K. (Frontiers Media, 2022)

In a world with an increasing population at risk of exposure to arthropod-borne flaviviruses, access to timely and accurate diagnostic tests would impact profoundly on the management of cases. Twenty peptides previously ...
Perfiles de expresión de microRNAs de respuesta inflamatoria en pacientes HTLV-1 positivos asintomáticos y en pacientes con Paraparesia Espástica Tropical

Rosado Sandoval, Javier Jason (Universidad Peruana Cayetano HerediaPE, 2014)

El virus Linfotrópico de las células T del humano (HTLV-1) es el agente etiológico de la Paraparesia Espástica Tropical (PET) y de la Leucemia de células T del adulto (ATLL). El conocimiento de la implicancia de los miRNAs ...
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1

Talledo Albujar, Michael John; López, G.; Huyghe, J.R.; Verdonck, K.; González Lagos, Elsa Violeta; Clark, D.; Vanham, G.; Gotuzzo Herencia, José Eduardo; van Camp, G.; van Laer, L. (Wiley, 2012)

The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive disease causing paraparesis of the lower limbs. Only a ...
Producción y evaluación de proteínas con potencial uso en el diagnóstico del Virus Linfotrópico de Células T Humanas Tipo 1 (HTLV-1)

Ocampo Acuña, Claudia Liliannie (Universidad Peruana Cayetano HerediaPE, 2017)

Introducción: La infección por HTLV-1 es considerada una enfermedad desatendida, la cual afecta sobremanera a los más pobres. En nuestro país se ha estimado de 150 000 a 450 000 portadores infectados, cifra que puede ser ...
Recombinant antigens for specific and sensitive serodiagnosis of Latin American tegumentary leishmaniasis

Montoya, Y.; Leon, C.; Talledo Albujar, Michael John; Nolasco, O.; Padilla, C.; Muñoz-Najar, U.; Barker, D.C. (Oxford University Press, 1997)

The diagnostic potential of recombinant leishmanial antigens for Latin American tegumentary leishmaniasis (LATL) was examined. Two Leishmania (Viannia) peruviana recombinant proteins, T26-U2 and T26-U4, were assessed by ...
Reliable Serological Diagnostic Tests for Arboviruses: Feasible or Utopia?

Kerkhof, Karen; Falconi-Agapito, Francesca; Van Esbroeck, Marjan; Talledo Albujar, Michael John; Ariën, Kevin K. (Elsevier, 2020)

Infections with arthropod-bome viruses are increasing globally as a result of climate and demographic changes, global dispersion of insect vectors, and increased air travel. The similar symptomatology of arboviral diseases ...
Robustness of serologic investigations for Chikungunya and Mayaro viruses following coemergence

Fischer, Carlo; Bozza, Fernando; Merino Merino, Xiomara Jeanleny; Pedroso, Celia; de Oliveira Filho, Edmilson F.; Moreira-Soto, Andrés; Schwalb Calderon, Alvaro; de Lamballerie, Xavier; Netto, Eduardo Martins; Bozza, Patrícia T.; Sarno, Manoel; Brites, Carlos; Gotuzzo Herencia, José Eduardo; Talledo Albujar, Michael John; Drexler, Jan Felix (American Society for Microbiology, 2020)

Since 2013, the arthropod-borne Chikungunya virus (CHIKV) has cocirculated with the autochthonous Mayaro virus (MAYV) in Latin America. Both belong to the same alphavirus serocomplex, termed the Semliki Forest serocomplex. ...
Salud mental en médicos que realizan el servicio rural, urbano-marginal en salud en el Perú: Un estudio de línea base

Galán-Rodas, E.; Gálvez-Buccollini, J.A.; Vega-Galdós, F.; Osada, J.; Guerrero-Padilla, D.; Vega-Dienstmaier, J.; Talledo Albujar, Michael John; Catacora, M.; Fiestas, F. (Instituto Nacional de Salud, 2011)

The disadvantageous conditions in which young physicians have to do their rural and sub-urban health service (SERUMS) may put them in a high risk for mental disorders. This study aims to establish the baseline levels of ...
Screening for human t-cell lymphotropic virus (Htlv) in pregnant women in the peruvian amazon and systematic review with meta-analysis of htlv infection in Peru

Ramos-Rincón, J.-M.; Ortiz-Martínez, S.; Vásquez-Chasnamote, M.-E.; De-Miguel-Balsa, E.; Gamboa-Paredes, O.-N.; Talledo Albujar, Michael John; López-Campana, G.; Celis-Salinas, J.C.; Prieto-Pérez, L.; Górgolas-Hernández, M.; Casapía-Morales, M. (MDPI, 2021)

Background. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the ...