Listar por tema "human cell"

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  • Anti-helicobacter pylori properties of the ant-venom peptide bicarinalin 
    Guzman, J.; Téné, N.; Touchard, A.; Castillo Pareja, Denis Helan; Belkhelfa, H.; Haddioui-Hbabi, L.; Treilhou, M.; Sauvain, Michel Henri Auguste (MDPI, 2018)
    The venom peptide bicarinalin, previously isolated from the ant Tetramorium bicarinatum, is an antimicrobial agent with a broad spectrum of activity. In this study, we investigate the potential of bicarinalin as a novel ...
  • Antiviral Resistance and Correlates of Virologic Failure in the first Cohort of HIV-Infected Children Gaining Access to Structured Antiretroviral Therapy in Lima, Peru: A Cross-Sectional Analysis 
    Rath, Barbara A.; von Kleist, Max; Castillo, Maria E.; Kolevic, Lenka; Caballero, Patricia; Soto-Castellares, Giselle; Amedee, Angela M.; Robinson, James E.; Katzenstein, David K.; Van Dyke, Russell B.; Oberhelman, Richard A. (BioMed Central, 2013)
    Background: The impact of extended use of ART in developing countries has been enormous. A thorough understanding of all factors contributing to the success of antiretroviral therapy is required. The current study aims to ...
  • Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy 
    Moens, B.; Decanine, D.; Menezes, S.M.; Khouri, R.; Silva-Santos, G.; Lopez, G.; Alvarez, C.; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; de Almeida Kruschewsky, R.; Galvão-Castro, B.; Vandamme, A.-M.; van Weyenbergh, J. (Public Library of Science, 2012)
    Background: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar ...
  • Association between Human Papillomavirus and Human T-Lymphotropic Virus in Indigenous Women from the Peruvian Amazon 
    Blas Blas, Magaly Marlitz; Alva, I.E.; Garcia Funegra, Patricia Jannet; Cárcamo Cavagnaro, César Paul Eugenio; Montano, S.M.; Muñante, R.; Zunt, J.R. (Public Library of Science, 2012)
    Background: No association between the Human T-cell lymphotropic virus (HTLV), an oncogenic virus that alters host immunity, and the Human Papillomavirus (HPV) has previously been reported. Examining the association between ...
  • Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles 
    Sanchez, Flor; Le, A.H.; Ho, V.N.A.; Romero Loyola, Sergio Jean Markos; Van Ranst, H.; De Vos, M.; Gilchrist, R.B.; Ho, T.M.; Vuong, L.N.; Smitz, J. (Springer, 2019)
    Purpose: To investigate the effectiveness of a biphasic IVM culture strategy at improving IVM outcomes in oocytes from small follicles (< 6 mm) compared with routine Standard IVM in patients with polycystic ovaries. Methods: ...
  • CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis 
    Menezes, Soraya Maria; Decanine, Daniele; Brassat, David; Khouri, Ricardo; Schnitman, Saul V.; Kruschewsky, Ramon; López, Giovanni; Alvarez, Carolina; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Vandamme, Anne-Mieke; Galvão-Castro, Bernardo; Liblau, Roland; Weyenbergh, Johan Van (BioMed Central, 2014)
    Background: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no ...
  • Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists 
    Sarmiento, J.; Shumate, C.; Suetomi, K.; Ravindran, A.; Villegas, L.; Rajarathnam, K.; Navarro, J. (Public Library of Science, 2011)
    CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis ...
  • Ex Vivo Innate Immune Cytokine Signature of Enhanced Risk of Relapsing Brucellosis 
    Feldman, Kristyn E.; Loriaux, Paul M.; Saito, Mayuko; Tuero Ochoa, Iskra; Villaverde, Homarh; Siva, Tenaya; Gotuzzo Herencia, José Eduardo; Gilman, Robert Hugh; Hoffmann, Alexander; Vinetz, Joseph Michael (Public Library of Science, 2013)
    Brucellosis, a zoonotic infection caused by one of the Gram-negative intracellular bacteria of the Brucella genus, is an ongoing public health problem in Perú. While most patients who receive standard antibiotic treatment ...
  • Fecal leukocytes in children infected with diarrheagenic Escherichia coli. 
    Mercado, Erik H.; Ochoa Woodell, Theresa Jean; Ecker, Lucie; Cabello Vílchez, Alfonso Martín; Durand Vara, David Percy; Barletta, Francesca; Molina, Margarita; Gil, Ana I.; Huicho Oriundo, Luis; Lanata, Claudio F.; Cleary, Thomas G. (American Society for Microbiology, 2011)
    The purpose of this study was to determine the presence and quantity of fecal leukocytes in children infected with diarrheagenic Escherichia coli and to compare these levels between diarrhea and control cases. We analyzed ...
  • A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia 
    Adhikari, K.; Mendoza-Revilla, J.; Sohail, A.; Fuentes-Guajardo, M.; Lampert, J.; Chacón-Duque, J.C.; Hurtado, M.; Villegas, V.; Granja, V.; Acuña-Alonzo, V.; Jaramillo, C.; Arias, W.; Lozano, R.B.; Everardo, P.; Gómez-Valdés, J.; Villamil-Ramírez, H.; Silva de Cerqueira, C.C.; Hunemeier, T.; Ramallo, V.; Schuler-Faccini, L.; Salzano, F.M.; Gonzalez-José, R.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo López-Aliaga, Carla Maria; Poletti, G.; Bedoya, G.; Rothhammer, F.; Tobin, D.J.; Fumagalli, M.; Balding, D.; Ruiz-Linares, A. (Springer Nature, 2019)
    We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation ...
  • Mortality and loss to follow-up among HIV-infected persons on long-term antiretroviral therapy in Latin America and the Caribbean 
    Carriquiry, G.; Fink, V.; Koethe, J.R.; Giganti, M.J.; Jayathilake, K.; Blevins, M.; Cahn, P.; Grinsztejn, B.; Wolff, M.; Pape, J.W.; Padgett, D.; Sierra Madero, J.; Gotuzzo Herencia, José Eduardo; McGowan, C.C.; Shepherd, B.E. (Wiley, 2015)
    Introduction: Long-term survival of HIV patients after initiating highly active antiretroviral therapy (ART) has not been sufficiently described in Latin America and the Caribbean, as compared to other regions. The aim of ...
  • Novel antibodies directed against the human erythropoietin receptor: Creating a basis for clinical implementation 
    Maxwell, P.; Melendez-Rodríguez, F.; Matchett, K.B.; Aragones, J.; Ben-Califa, N.; Jaekel, H.; Hengst, L.; Lindner, H.; Bernardini, A.; Brockmeier, U.; Fandrey, J.; Grunert, F.; Oster, H.S.; Mittelman, M.; El-Tanani, M.; Thiersch, M.; Schneider Gasser, E.M.; Gassmann, M.; Dangoor, D.; Cuthbert, R.J.; Irvine, A.; Jordan, A.; Lappin, T.; Thompson, J.; Neumann, D. (Wiley, 2014)
    Recombinant human erythropoietin (rHuEPO) is an effective treatment for anaemia but concerns that it causes disease progression in cancer patients by activation of EPO receptors (EPOR) in tumour tissue have been controversial ...
  • Patrones de adherencia de cepas de Escherichia coli Difusamente adherente (DAEC) provenientes de niños con y sin diarrea 
    Riveros Ramirez, Maribel Denise; Barletta, F.; Cabello Vílchez, Alfonso Martín; Durand Vara, David Percy; Mercado, E.H.; Contreras, C.; Rivera, F.P.; Mosquito, S.; Lluque, A.; Ochoa Woodell, Theresa Jean (Instituto Nacional de Salud, 2011)
    Introduction. Diffusely adherent E. coli (DAEC) is the sixth recognized group of diarrheagenic E. coli. However, its association with diarrhea remains controversial. Variability in the adherence patterns of clinical strains ...
  • Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells 
    Reyes-Reyes, E.M.; Jin, Z.; Vaisberg Wollach, Abraham Jaime; Hammond, G.B.; Bates, P.J. (American Chemical Society, 2013)
    Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of ...
  • Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines 
    Moens, B.; Pannecouque, C.; Lápez, G.; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Khouri, R.; Bittencourt, A.; Farré, L.; Galvão-Castro, B.; Vandamme, A.-M.; Van Weyenbergh, J. (BioMed Central, 2012)
    Background: IFN- contributes extensively to host immune response upon viral infection through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although extensively documented in various types ...
  • Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives 
    Estevez, Y.; Quiliano, M.; Burguete, A.; Cabanillas Amado, Billy Joel; Zimic-Peralta, Mirko Juan; Málaga, E.; Verastegui Pimentel, Manuela Renee; Pérez-Silanes, S.; Aldana, I.; Monge, A.; Castillo Pareja, Denis Helan; Deharo, E. (Elsevier, 2011)
    Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania peruviana and Trypanosoma cruzi. Both series were tested for toxicity against proliferative and non-proliferative cells. ...
  • Tuberculous Meningitis: Impact of Timing of Treatment Initiation on Mortality 
    Soria, J.; Chiappe, A.; Gallardo, J.; Zunt, J.R.; Lescano Guevara, Andres Guillermo (Oxford University Press, 2021)
    We conducted a retrospective cross-sectional study of adult hospitalized patients with confirmed tuberculous meningitis to determine the impact of the timing of treatment initiation on mortality. The mortality of tuberculous ...
  • Whole-Genome sequencing uncovers the genetic basis of chronic mountain sickness in andean highlanders 
    Zhou, Dan; Udpa, Nitin; Ronen, Roy; Stobdan, Tsering; Liang, Junbin; Appenzeller, Otto; Zhao, Huiwen W.; Yin, Yi; Du, Yuanping; Guo, Lixia; Cao, Rui.; Wang, Yu; Jin, Xin; Huang, Chen; Jia, Wenlong; Cao, Dandan; Guo, Guangwu; Gamboa, Jorge L.; Villafuerte, Francisco C.; Callacondo, David; Xue, Jin; Liu, Siqi; Frazer, Kelly A.; Li, Yingrui; Bafna, Vineet; Haddad, Gabriel G. (Elsevier, 2013)
    The hypoxic conditions at high altitudes present a challenge for survival, causing pressure for adaptation. Interestingly, many highaltitude denizens (particularly in the Andes) are maladapted, with a condition known as ...

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