DSpace Repository

Browsing Artículos by Subject "Polymorphism, Single Nucleotide"

Browsing Artículos by Subject "Polymorphism, Single Nucleotide"

Sort by: Order: Results:

  • Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Quinto-Sanchez, Mirsha; Mendoza-Revilla, Javier; Camilo-Chacon-Duque, Juan; Acuna-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Barquera Lozano, Rodrigo; Perez, Gaston-Macin; Gomez-Valdes, Jorge; Villamil-Ramirez, Hugo; Hunemeier, Tabita; Ramallo, Virginia; Silva-de-Cerqueira, Caio-C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco-M.; Bortolini, Maria-Catira; Canizales-Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya, Gabriel; Rothhammer, Francisco; Headon, Denis; Gonzalez-Jose, Rolando; Balding, David; Ruiz-Linares, Andres (Nature Research, 2016)
    We report a genome-wide association scan for facial features in approximately 6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 x 10(-8)) at single-nucleotide ...
  • Adhikari, Kaustubh; Reales, Guillermo; Smith, Andrew J. P.; Konka, Esra; Palmen, Jutta; Quinto-Sanchez, Mirsha; Acuna-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, Maria; Barquera Lozano, Rodrigo; Macin Perez, Gaston; Gomez-Valdes, Jorge; Villamil-Ramirez, Hugo; Hunemeier, Tabita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria-Catira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Calderon, Rosario; Rosique, Javier; Cheeseman, Michael; Bhutta, Mahmood F.; Humphries, Steve E.; Gonzalez-Jose, Rolando; Headon, Denis; Balding, David; Ruiz-Linares, Andres (Nature Research, 2015)
    Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find genome-wide significant association at seven genomic regions affecting: lobe size and attachment, ...
  • 1000 Genomes Project; Auton, A.; Abecasis, G.R.; Altshuler, D.M.; Durbin, R.M.; Bentley, D.R.; Chakravarti, A.; Clark, A.G.; Donnelly, P.; Eichler, E.E.; Flicek, P.; Gabriel, S.B.; Gibbs, R.A.; Green, E.D.; Hurles, M.E.; Knoppers, B.M.; Korbel, J.O.; Lander, E.S.; Lee, C.; Lehrach, H.; Mardis, E.R.; Marth, G.T.; McVean, G.A.; Nickerson, D.A.; Schmidt, J.P.; Sherry, S.T.; Wang, J.; Wilson, R.K.; Boerwinkle, E.; Doddapaneni, H.; Han, Y.; Korchina, V.; Kovar, C.; Lee, S.; Muzny, D.; Reid, J.G.; Zhu, Y.; Chang, Y.; Feng, Q.; Fang, X.; Guo, X.; Jian, M.; Jiang, H.; Jin, X.; Lan, T.; Li, G.; Li, J.; Li, Y.; Liu, S.; Liu, X.; Lu, Y.; Ma, X.; Tang, M.; Wang, B.; Wang, G.; Wu, H.; Wu, R.; Xu, X.; Yin, Y.; Zhang, D.; Zhang, W.; Zhao, J.; Zhao, M.; Zheng, X.; Gupta, N.; Gharani, N.; Toji, L.H.; Gerry, N.P.; Resch, A.M.; Barker, J.; Clarke, L.; Gil, L.; Hunt, S.E.; Kelman, G.; Kulesha, E.; Leinonen, R.; McLaren, W.M.; Radhakrishnan, R.; Roa, A.; Smirnov, D.; Smith, R.E.; Streeter, I.; Thormann, A.; Toneva, I.; Vaughan, B.; Zheng-Bradley, X.; Grocock, R.; Humphray, S.; James, T.; Kingsbury, Z.; Sudbrak, R.; Albrecht, M.W.; Amstislavskiy, V.S.; Borodina, T.A.; Lienhard, M.; Mertes, F.; Sultan, M.; Timmermann, B.; Yaspo, M.-L.; Fulton, L.; Ananiev, V.; Belaia, Z.; Beloslyudtsev, D.; Bouk, N.; Chen, C.; Church, D.; Cohen, R.; Cook, C.; Garner, J.; Hefferon, T.; Kimelman, M.; Liu, C.; Lopez, J.; Meric, P.; O'Sullivan, C.; Ostapchuk, Y.; Phan, L.; Ponomarov, S.; Schneider, V.; Shekhtman, E.; Sirotkin, K.; Slotta, D.; Zhang, H.; Balasubramaniam, S.; Burton, J.; Danecek, P.; Keane, T.M.; Kolb-Kokocinski, A.; McCarthy, S.; Stalker, J.; Quail, M.; Davies, C.J.; Gollub, J.; Webster, T.; Wong, B.; Zhan, Y.; Campbell, C.L.; Kong, Y.; Marcketta, A.; Yu, F.; Antunes, L.; Bainbridge, M.; Sabo, A.; Huang, Z.; Coin, L.J.M.; Fang, L.; Li, Q.; Li, Z.; Lin, H.; Liu, B.; Luo, R.; Shao, H.; Xie, Y.; Ye, C.; Yu, C.; Zhang, F.; Zheng, H.; Zhu, H.; Alkan, C.; Dal, E.; Kahveci, F.; Garrison, E.P.; Kural, D.; Lee, W.-P.; Leong, W.F.; Stromberg, M.; Ward, A.N.; Wu, J.; Zhang, M.; Daly, M.J.; DePristo, M.A.; Handsaker, R.E.; Banks, E.; Bhatia, G.; Del Angel, G.; Genovese, G.; Li, H.; Kashin, S.; McCarroll, S.A.; Nemesh, J.C.; Poplin, R.E.; Yoon, S.C.; Lihm, J.; Makarov, V.; Gottipati, S.; Keinan, A.; Rodriguez-Flores, J.L.; Rausch, T.; Fritz, M.H.; Stütz, A.M.; Beal, K.; Datta, A.; Herrero, J.; Ritchie, G.R.S.; Zerbino, D.; Sabeti, P.C.; Shlyakhter, I.; Schaffner, S.F.; Vitti, J.; Cooper, D.N.; Ball, E.V.; Stenson, P.D.; Barnes, B.; Bauer, M.; Cheetham, R.K.; Cox, A.; Eberle, M.; Kahn, S.; Murray, L.; Peden, J.; Shaw, R.; Kenny, E.E.; Batzer, M.A.; Konkel, M.K.; Walker, J.A.; MacArthur, D.G.; Lek, M.; Herwig, R.; Ding, L.; Koboldt, D.C.; Larson, D.; Ye, K.; Gravel, S.; Swaroop, A.; Chew, E.; Lappalainen, T.; Erlich, Y.; Gymrek, M.; Willems, T.F.; Simpson, J.T.; Shriver, M.D.; Rosenfeld, J.A.; Bustamante, C.D.; Montgomery, S.B.; De La Vega, F.M.; Byrnes, J.K.; Carroll, A.W.; DeGorter, M.K.; Lacroute, P.; Maples, B.K.; Martin, A.R.; Moreno-Estrada, A.; Shringarpure, S.S.; Zakharia, F.; Halperin, E.; Baran, Y.; Cerveira, E.; Hwang, J.; Malhotra, A.; Plewczynski, D.; Radew, K.; Romanovitch, M.; Zhang, C.; Hyland, F.C.L.; Craig, D.W.; Christoforides, A.; Homer, N.; Izatt, T.; Kurdoglu, A.A.; Sinari, S.A.; Squire, K.; Xiao, C.; Sebat, J.; Antaki, D.; Gujral, M.; Noor, A.; Ye, K.; Burchard, E.G.; Hernandez, R.D.; Gignoux, C.R.; Haussler, D.; Katzman, S.J.; Kent, W.J.; Howie, B.; Ruiz-Linares, A.; Dermitzakis, E.T.; Devine, S.E.; Kang, H.M.; Kidd, J.M.; Blackwell, T.; Caron, S.; Chen, W.; Emery, S.; Fritsche, L.; Fuchsberger, C.; Jun, G.; Li, B.; Lyons, R.; Scheller, C.; Sidore, C.; Song, S.; Sliwerska, E.; Taliun, D.; Tan, A.; Welch, R.; Wing, M.K.; Zhan, X.; Awadalla, P.; Hodgkinson, A.; Li, Y.; Shi, X.; Quitadamo, A.; Lunter, G.; Marchini, J.L.; Myers, S.; Churchhouse, C.; Delaneau, O.; Gupta-Hinch, A.; Kretzschmar, W.; Iqbal, Z.; Mathieson, I.; Menelaou, A.; Rimmer, A.; Xifara, D.K.; Oleksyk, T.K.; Fu, Y.; Liu, X.; Xiong, M.; Jorde, L.; Witherspoon, D.; Xing, J.; Browning, B.L.; Browning, S.R.; Hormozdiari, F.; Sudmant, P.H.; Khurana, E.; Tyler-Smith, C.; Albers, C.A.; Ayub, Q.; Chen, Y.; Colonna, V.; Jostins, L.; Walter, K.; Xue, Y.; Gerstein, M.B.; Abyzov, A.; Balasubramanian, S.; Chen, J.; Clarke, D.; Fu, Y.; Harmanci, A.O.; Jin, M.; Lee, D.; Liu, J.; Mu, X.J.; Zhang, J.; Zhang, Y.; Hartl, C.; Shakir, K.; Degenhardt, J.; Meiers, S.; Raeder, B.; Casale, F.P.; Stegle, O.; Lameijer, E.-W.; Hall, I.; Bafna, V.; Michaelson, J.; Gardner, E.J.; Mills, R.E.; Dayama, G.; Chen, K.; Fan, X.; Chong, Z.; Chen, T.; Chaisson, M.J.; Huddleston, J.; Malig, M.; Nelson, B.J.; Parrish, N.F.; Blackburne, B.; Lindsay, S.J.; Ning, Z.; Zhang, Y.; Lam, H.; Sisu, C.; Challis, D.; Evani, U.S.; Lu, J.; Nagaswamy, U.; Yu, J.; Li, W.; Habegger, L.; Yu, H.; Cunningham, F.; Dunham, I.; Lage, K.; Jespersen, J.B.; Horn, H.; Kim, D.; Desalle, R.; Narechania, A.; Sayres, M.A.W.; Mendez, F.L.; Poznik, G.D.; Underhill, P.A.; Mittelman, D.; Banerjee, R.; Cerezo, M.; Fitzgerald, T.W.; Louzada, S.; Massaia, A.; Yang, F.; Kalra, D.; Hale, W.; Dan, X.; Barnes, K.C.; Beiswanger, C.; Cai, H.; Cao, H.; Henn, B.; Jones, D.; Kaye, J.S.; Kent, A.; Kerasidou, A.; Mathias, R.; Ossorio, P.N.; Parker, M.; Rotimi, C.N.; Royal, C.D.; Sandoval, K.; Su, Y.; Tian, Z.; Tishkoff, S.; Via, M.; Wang, Y.; Yang, H.; Yang, L.; Zhu, J.; Bodmer, W.; Bedoya, G.; Cai, Z.; Gao, Y.; Chu, J.; Peltonen, L.; Garcia-Montero, A.; Orfao, A.; Dutil, J.; Martinez-Cruzado, J.C.; Mathias, R.A.; Hennis, A.; Watson, H.; McKenzie, C.; Qadri, F.; LaRocque, R.; Deng, X.; Asogun, D.; Folarin, O.; Happi, C.; Omoniwa, O.; Stremlau, M.; Tariyal, R.; Jallow, M.; Joof, F.S.; Corrah, T.; Rockett, K.; Kwiatkowski, D.; Kooner, J.; Hien, T.T.; Dunstan, S.J.; ThuyHang, N.; Fonnie, R.; Garry, R.; Kanneh, L.; Moses, L.; Schieffelin, J.; Grant, D.S.; Gallo, Carla; Poletti, Giovanni; Saleheen, D.; Rasheed, A.; Brooks, L.D.; Felsenfeld, A.L.; McEwen, J.E.; Vaydylevich, Y.; Duncanson, A.; Dunn, M.; Schloss, J.A. (Nature Research, 2015)
    The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report ...
  • Adhikari, Kaustubh; Mendoza-Revilla, Javier; Sohail, Anood; Fuentes-Guajardo, Macarena; Lampert, Jodie; Chacon-Duque, Juan Camilo; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Acuna-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; Everardo, Paola; Gomez-Valdes, Jorge; Villamil-Ramirez, Hugo; Silva de Cerqueira, Caio C.; Hunemeier, Tabita; Ramallo, Virginia; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Gonzalez-Jose, Rolando; Bortolini, Maria-Catira; Canizales-Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Tobin, Desmond J.; Fumagalli, Matteo; Balding, David; Ruiz-Linares, Andres (Nature Research, 2019)
    We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation ...
  • Adhikari, K.; Mendoza-Revilla, J.; Sohail, A.; Fuentes-Guajardo, M.; Lampert, J.; Chacón-Duque, J.C.; Hurtado, M.; Villegas, V.; Granja, V.; Acuña-Alonzo, V.; Jaramillo, C.; Arias, W.; Lozano, R.B.; Everardo, P.; Gómez-Valdés, J.; Villamil-Ramírez, H.; Silva de Cerqueira, C.C.; Hunemeier, T.; Ramallo, V.; Schuler-Faccini, L.; Salzano, F.M.; Gonzalez-José, R.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo, C.; Poletti, G.; Bedoya, G.; Rothhammer, F.; Tobin, D.J.; Fumagalli, M.; Balding, D.; Ruiz-Linares, A. (Nature Research, 2019)
    We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation ...
  • Sheen, Patricia; Requena, David; Gushiken, Eduardo; Gilman, Robert H.; Antiparra, Ricardo; Lucero, Bryan; Lizárraga, Pilar; Cieza, Basilio; Roncal, Elisa; Grandjean, Louis; Pain, Arnab; McNerney, Ruth; Clark, Taane G.; Moore, David; Zimic, Mirko (BMC, 2017)
    BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
  • Gustafsson, Mika; Gawel, Danuta R.; Alfredsson, Lars; Baranzini, Sergio; Bjorkander, Janne; Blomgran, Robert; Hellberg, Sandra; Eklund, Daniel; Ernerudh, Jan; Kockum, Ingrid; Konstantinell, Aelita; Lahesmaa, Riita; Lentini, Antonio; Liljenstrom, H. Robert I.; Mattson, Lina; Matussek, Andreas; Mellergard, Johan; Mendez, Melissa; Olsson, Tomas; Pujana, Miguel A.; Rasool, Omid; Serra-Musach, Jordi; Stenmarker, Margaretha; Tripathi, Subhash; Viitala, Miro; Wang, Hui; Zhang, Huan; Nestor, Colm E.; Benson, Mikael (American Association for the Advancement of Science, 2015)
    Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally ...
  • Grandjean, Louis; Gilman, Robert H.; Iwamoto, Tomatada; Köser, Claudio U.; Coronel, Jorge; Zimic, Mirko; Török, M. Estee; Ayabina, Diepreye; Kendall, Michelle; Fraser, Christophe; Harris, Simon; Parkhill, Julian; Peacock, Sharon J.; Moore, David A. J.; Colijn, Caroline (Public Library of Science, 2017)
    BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic ...
  • Fuentes, M.; Pulgar, I.; Gallo, C.; Bortolini, M.-C.; Canizales-Quinteros, S.; Bedoya, G.; González-José, R.; Ruiz-Linares, A.; Rothhammer, F. (Sociedad Médica de Santiago, 2014)
    Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate ...
  • Campos, M.; Alonso, D.P.; Conn, J.E.; Vinetz, J.M.; Emerson, K.J.; Ribolla, P.E.M. (BMC, 2019)
    Background: In the Amazon Basin, Nyssorhynchus (Anopheles) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline vectors such as host preference, biting time and ...
  • Childebayeva, Ainash; Jones, Tamara R.; Goodrich, Jaclyn M.; Leon-Velarde, Fabiola; Rivera-Chira, Maria; Kiyamu, Melisa; Brutsaert, Tom D.; Dolinoy, Dana C.; Bigham, Abigail W. (Taylor & Francis, 2019)
    Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain ...
  • Childebayeva, A.; Jones, T.R.; Goodrich, J.M.; Leon-Velarde, F.; Rivera-Chira, M.; Kiyamu, M.; Brutsaert, T.D.; Dolinoy, D.C.; Bigham, A.W. (Taylor & Francis, 2019)
    Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain ...
  • Campos, Melina; Conn, Jan E.; Alonso, Diego Peres; Vinetz, Joseph M.; Emerson, Kevin J.; Ribolla, Paulo Eduardo Martins (BMC, 2017)
    BACKGROUND: In recent decades, throughout the Amazon Basin, landscape modification contributing to profound ecological change has proceeded at an unprecedented rate. Deforestation that accompanies human activities can ...
  • Sikora, Martin; Carpenter, Meredith L.; Moreno-Estrada, Andres; Henn, Brenna M.; Underhill, Peter A.; Sanchez-Quinto, Federico; Zara, Ilenia; Pitzalis, Maristella; Sidore, Carlo; Busonero, Fabio; Maschio, Andrea; Angius, Andrea; Jones, Chris; Mendoza-Revilla, Javier; Nekhrizov, Georgi; Dimitrova, Diana; Theodossiev, Nikola; Harkins, Timothy T.; Keller, Andreas; Maixner, Frank; Zink, Albert; Abecasis, Goncalo; Sanna, Serena; Cucca, Francesco; Bustamante, Carlos D. (Public Library of Science, 2014)
    Genome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights into his origin and relationship to modern European populations. ...
  • Zamudio, Roxana; Pereira, Latife; Rocha, Carolina D.; Berg, Douglas E.; Muniz-Queiroz, Thais; Sant Anna, Hanaisa P.; Cabrera, Lilia; Combe, Juan M.; Herrera, Phabiola; Jahuira, Martha H.; Leao, Felipe B.; Lyon, Fernanda; Prado, William A.; Rodrigues, Maira R.; Rodrigues-Soares, Fernanda; Santolalla, Meddly L.; Zolini, Camila; Silva, Aristobolo M.; Gilman, Robert H.; Tarazona-Santos, Eduardo; Kehdy, Fernanda S. G. (Springer, 2015)
    Background. Gastric adenocarcinoma is associated with chronic infection by Helicobacter pylori and with the host inflammatory response triggered by it, with substantial inter-person variation in the immune response profile ...
  • Phelan, Jody-E.; Coll, Francesc; Bergval, Indra; Anthony, Richard-M.; Warren, Rob; Sampson, Samantha-L.; Gey-van-Pittius, Nicolaas-C.; Glynn, Judith-R.; Crampin, Amelia-C.; Alves, Adriana; Bessa, Theolis-Barbosa; Campino, Susana; Dheda, Keertan; Grandjean, Louis; Hasan, Rumina; Hasan, Zahra; Miranda, Anabela; Moore, David; Panaiotov, Stefan; Perdigao, Joao; Portugal, Isabel; Sheen, Patricia; de-Oliveira-Sousa, Erivelton; Streicher, Elizabeth-M.; van-Helden, Paul-D.; Viveiros, Miguel; Hibberd, Martin-L.; Pain, Arnab; McNerney, Ruth; Clark, Taane-G. (BMC, 2016)
    BACKGROUND: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families ...
  • Rosado, Jason; Morales, Sandra; Lopez, Giovanni; Clark, Daniel; Verdonck, Kristien; Gotuzzo, Eduardo; Van Camp, Guy; Talledo, Michael (Wiley, 2016)
    Human T‐lymphotropic virus 1 (HTLV‐1) is the etiologic agent of the HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross‐linking ...
  • Espinoza, Jose R.; Alvarez, Giancarlo; Leon-Velarde, Fabiola; Preciado, Hugo F. Ju; Macarlupu, Jose-Luis; Rivera-Ch, Maria; Rodriguez, Jorge; Favier, Judith; Gimenez-Roqueplo, Anne-Paule; Richalet, Jean-Paul (Mary Ann Liebert, 2014)
    A study of chronic mountain sickness (CMS) with a candidate gene--vascular endothelial growth factor A (VEGFA)--was carried out in a Peruvian population living at high altitude in Cerro de Pasco (4380 m). The study was ...

Search DSpace


Browse

My Account