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Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death

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dc.contributor.author Stivers, Nicole S.
dc.contributor.author Islam, Ashraful
dc.contributor.author Reyes-Reyes, Elsa M.
dc.contributor.author Casson, Lavona K.
dc.contributor.author Aponte, José C.
dc.contributor.author Vaisberg, Abraham J.
dc.contributor.author Hammond, Gerald B.
dc.contributor.author Bates, Paula J.
dc.date.accessioned 2018-11-30T22:50:35Z
dc.date.available 2018-11-30T22:50:35Z
dc.date.issued 2018
dc.identifier.uri http://doi.org/10.3390/molecules23061418
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/4151
dc.description.abstract We previously reported on the isolation and biological activities of plagiochiline A (1), a 2,3-secoaromadendrane-type sesquiterpenoid from the Peruvian medicinal plant, Plagiochila disticha. This compound was found to have antiproliferative effects on a variety of solid tumor cell lines, as well as several leukemia cell lines. Other researchers have also noted the cytotoxicity of plagiochiline A (isolated from different plant species), but there are no prior reports regarding the mechanism for this bioactivity. Here, we have evaluated the effects of plagiochiline A on cell cycle progression in DU145 prostate cancer cells. A cell cycle analysis indicated that plagiochiline A caused a significant increase in the percentage of cells in the G₂/M phase when compared with control cells. When cells were stained and observed by fluorescence microscopy to examine progress through the mitotic phase, we found a significant increase in the proportion of cells with features of late cytokinesis (cells connected by intercellular bridges) in the plagiochiline A-treated samples. These results suggest that plagiochiline A inhibits cell division by preventing completion of cytokinesis, particularly at the final abscission stage. We also determined that plagiochiline A reduces DU145 cell survival in clonogenic assays and that it induces substantial cell death in these cells.
dc.language.iso eng
dc.publisher MDPI
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans
dc.subject Male
dc.subject Plant Extracts
dc.subject abscission
dc.subject Cell Line, Tumor
dc.subject Cell Proliferation
dc.subject Cell Survival
dc.subject cytokinesis
dc.subject Cytokinesis
dc.subject Embryophyta
dc.subject Epoxy Compounds
dc.subject Plagiochila disticha
dc.subject plagiochiline A
dc.subject Prostatic Neoplasms
dc.subject Pyrans
dc.title Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death
dc.type info:eu-repo/semantics/article
dc.identifier.journal Molecules

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