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Carbapenem resistance in Pseudomonas aeruginosa and Acinetobacter baumannii in the nosocomial setting in Latin America

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dc.contributor.author Labarca, Jaime-A.
dc.contributor.author Salles, Mauro-Jose-Costa
dc.contributor.author Seas, Carlos
dc.contributor.author Guzman-Blanco, Manuel
dc.date.accessioned 2019-02-06T14:51:20Z
dc.date.available 2019-02-06T14:51:20Z
dc.date.issued 2014
dc.identifier.uri http://doi.org/10.3109/1040841X.2014.940494
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5223
dc.description.abstract Increasing prevalence of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii strains in the nosocomial setting in Latin America represents an emerging challenge to public health, as the range of therapeutic agents active against these pathogens becomes increasingly constrained. We review published reports from 2002 to 2013, compiling data from throughout the region on prevalence, mechanisms of resistance and molecular epidemiology of carbapenem-resistant strains of P. aeruginosa and A. baumannii. We find rates of carbapenem resistance up to 66% for P. aeruginosa and as high as 90% for A. baumannii isolates across the different countries of Latin America, with the resistance rate of A. baumannii isolates greater than 50% in many countries. An outbreak of the SPM-1 carbapenemase is a chief cause of resistance in P. aeruginosa strains in Brazil. Elsewhere in Latin America, members of the VIM family are the most important carbapenemases among P. aeruginosa strains. Carbapenem resistance in A. baumannii in Latin America is predominantly due to the oxacillinases OXA-23, OXA-58 and (in Brazil) OXA-143. Susceptibility of P. aeruginosa and A. baumannii to colistin remains high, however, development of resistance has already been detected in some countries. Better epidemiological data are needed to design effective infection control interventions.
dc.language.iso eng
dc.publisher Taylor & Francis
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject beta-Lactam Resistance
dc.subject Cross Infection
dc.subject Acinetobacter baumannii/drug effects
dc.subject Acinetobacter Infections/epidemiology/microbiology
dc.subject Anti-Bacterial Agents/pharmacology
dc.subject Carbapenem
dc.subject Carbapenems/pharmacology
dc.subject Humans
dc.subject Incidence
dc.subject infection
dc.subject Latin America
dc.subject Latin America/epidemiology
dc.subject nosocomial
dc.subject Population Surveillance
dc.subject Pseudomonas aeruginosa/drug effects
dc.subject Pseudomonas Infections/epidemiology/microbiology
dc.subject resistance
dc.title Carbapenem resistance in Pseudomonas aeruginosa and Acinetobacter baumannii in the nosocomial setting in Latin America
dc.type info:eu-repo/semantics/review
dc.identifier.journal Critical Reviews in Microbiology

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