Universidad Peruana Cayetano Heredia

A Controlled Study of Tuberculosis Diagnosis in HIV-Infected and Uninfected Children in Peru

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dc.contributor.author Oberhelman, Richard A.
dc.contributor.author Soto-Castellares, Giselle
dc.contributor.author Gilman, Robert H.
dc.contributor.author Castillo, Maria E.
dc.contributor.author Kolevic, Lenka
dc.contributor.author Delpino, Trinidad
dc.contributor.author Saito, Mayuko
dc.contributor.author Salazar-Lindo, Eduardo
dc.contributor.author Negron, Eduardo
dc.contributor.author Montenegro, Sonia
dc.contributor.author Laguna-Torres, V. Alberto
dc.contributor.author Maurtua-Neumann, Paola
dc.contributor.author Datta, Sumona
dc.contributor.author Evans, Carlton A.
dc.date.accessioned 2019-02-06T14:53:11Z
dc.date.available 2019-02-06T14:53:11Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.1371/journal.pone.0120915
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5399
dc.description.abstract BACKGROUND: Diagnosing tuberculosis in children is challenging because specimens are difficult to obtain and contain low tuberculosis concentrations, especially with HIV-coinfection. Few studies included well-controls so test specificities are poorly defined. We studied tuberculosis diagnosis in 525 children with and without HIV-infection. METHODS AND FINDINGS: 'Cases' were children with suspected pulmonary tuberculosis (n = 209 HIV-negative; n = 81 HIV-positive) and asymptomatic 'well-control' children (n = 200 HIV-negative; n = 35 HIV-positive). Specimens (n = 2422) were gastric aspirates, nasopharyngeal aspirates and stools analyzed by a total of 9688 tests. All specimens were tested with an in-house hemi-nested IS6110 PCR that took <24 hours. False-positive PCR in well-controls were more frequent in HIV-infection (P</=0.01): 17% (6/35) HIV-positive well-controls versus 5.5% (11/200) HIV-negative well-controls; caused by 6.7% (7/104) versus 1.8% (11/599) of their specimens, respectively. 6.7% (116/1719) specimens from 25% (72/290) cases were PCR-positive, similar (P>0.2) for
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Child
dc.subject Child, Preschool
dc.subject Infant
dc.subject Peru/epidemiology
dc.subject Polymerase Chain Reaction/methods
dc.subject HIV Infections/complications/diagnosis/epidemiology
dc.subject Tuberculosis/complications/diagnosis/epidemiology
dc.title A Controlled Study of Tuberculosis Diagnosis in HIV-Infected and Uninfected Children in Peru
dc.type info:eu-repo/semantics/article
dc.identifier.journal PLoS ONE


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