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Changes in Genetic Diversity from Field to Laboratory During Colonization of Anopheles darlingi Root (Diptera: Culicidae)

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dc.contributor.author Lainhart, William
dc.contributor.author Bickersmith, Sara A.
dc.contributor.author Moreno, Marta
dc.contributor.author Rios, Carlos Tong
dc.contributor.author Vinetz, Joseph M.
dc.contributor.author Conn, Jan E.
dc.date.accessioned 2019-02-06T14:57:38Z
dc.date.available 2019-02-06T14:57:38Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.4269/ajtmh.15-0336
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5467
dc.description.abstract The process of colonizing any arthropod species, including vector mosquitoes, necessarily involves adaptation to laboratory conditions. The adaptation and evolution of colonized mosquito populations needs consideration when such colonies are used as representative models for pathogen transmission dynamics. A recently established colony of Anopheles darlingi, the primary malaria vector in Amazonian South America, was tested for genetic diversity and bottleneck after 21 generations, using microsatellites. As expected, laboratory An. darlingi had fewer private and rare alleles (frequency < 0.05), decreased observed heterozygosity, and more common alleles (frequency > 0.50), but no significant evidence of a bottleneck, decrease in total alleles, or increase in inbreeding compared with field specimens (founder population). Low-moderate differentiation between field and laboratory populations was detected. With these findings, and the documented inherent differences between laboratory and field populations, results of pathogen transmission studies using this An. darlingi colony need to be interpreted cautiously.
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals
dc.subject Genetic Variation
dc.subject Microsatellite Repeats/genetics
dc.subject Anopheles/genetics
dc.subject Inbreeding
dc.subject Insect Vectors/genetics
dc.subject Laboratories
dc.subject Malaria/transmission
dc.title Changes in Genetic Diversity from Field to Laboratory During Colonization of Anopheles darlingi Root (Diptera: Culicidae)
dc.type info:eu-repo/semantics/article
dc.identifier.journal American Journal of Tropical Medicine and Hygiene


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