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Heterogeneous infectiousness in guinea pigs experimentally infected with Trypanosoma cruzi

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dc.contributor.author Castillo-Neyra, Ricardo
dc.contributor.author Borrini Mayori, Katty
dc.contributor.author Salazar Sanchez, Renzo
dc.contributor.author Ancca Suarez, Jenny
dc.contributor.author Xie, Sherrie
dc.contributor.author Naquira Velarde, Cesar
dc.contributor.author Levy, Michael Z.
dc.date.accessioned 2019-02-06T14:59:07Z
dc.date.available 2019-02-06T14:59:07Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.1016/j.parint.2015.09.009
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5542
dc.description.abstract Guinea pigs are important reservoirs of Trypanosoma cruzi , the causative parasite of Chagas disease, and in the Southern Cone of South America, transmission is mediated mainly by the vector Triatoma infestans . Interestingly, colonies of Triatoma infestans captured from guinea pig corrals sporadically have infection prevalence rates above 80%. Such high values are not consistent with the relatively short 7–8 week parasitemic period that has been reported for guinea pigs in the literature. We experimentally measured the infectious periods of a group of T. cruzi -infected guinea pigs by performing xenodiagnosis and direct microscopy each week for one year. Another group of infected guinea pigs received only direct microscopy to control for the effect that inoculation by triatomine saliva may have on parasitemia in the host. We observed infectious periods longer than those previously reported in a number of guinea pigs from both the xenodiagnosis and control groups. While some guinea pigs were infectious for a short time, other “super-shedders” were parasitemic up to 22 weeks after infection, and/or positive by xenodiagnosis for a year after infection. This heterogeneity in infectiousness has strong implications for T. cruzi transmission dynamics and control, as super-shedder guinea pigs may play a disproportionate role in pathogen spread.
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Trypanosoma cruzi
dc.subject Time Factors
dc.subject Animals
dc.subject South America
dc.subject Prevalence
dc.subject Triatoma infestans
dc.subject Parasitemia
dc.subject Cavia porcellus
dc.subject Chagas Disease/parasitology/transmission
dc.subject Disease Reservoirs/parasitology
dc.subject Guinea pig
dc.subject Guinea Pigs
dc.subject Infectiousness
dc.subject Saliva/parasitology
dc.subject Super-shedder
dc.subject Triatoma/parasitology
dc.subject Trypanosoma cruzi/physiology/ultrastructure
dc.subject Xenodiagnosis
dc.title Heterogeneous infectiousness in guinea pigs experimentally infected with Trypanosoma cruzi
dc.type info:eu-repo/semantics/article
dc.identifier.journal Parasitology International


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