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Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes

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dc.contributor.author Gonzales, Gustavo F.
dc.contributor.author Tapia, V.
dc.date.accessioned 2019-02-22T14:54:29Z
dc.date.available 2019-02-22T14:54:29Z
dc.date.issued 2014
dc.identifier.uri http://doi.org/10.1515/jbcpp-2013-0162
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5651
dc.description.abstract Background: Currently there are no studies on γ-glutamyltransferase (γGT) levels at high altitude or on the relationship between γGT, uric acid and several dysfunctions. The aim of the study was to determine the association between serum γGT and uric acid levels in subjects at high altitude with hemoglobin, glycemia, and lipidic, hepatic and kidney markers. Methods: The present study was performed in 487 subjects aged 30-75 years living at 4100 m of altitude. A venous blood sample was drawn from each subject to measure hemoglobin, glucose, and lipid levels and markers of liver and kidney function. Quartiles for serum γGT and uric acid were calculated and associated with different physiological variables. A p-value <0.05 was considered statistically significant. Results: Serum γGT values were higher in men (38.35± 2.54 IU/L) than in women (30.33±1.76 IU/L) (p<0.01). Similarly, serum uric acid levels were higher in men (5.78± 0.12 mg/dL) than in women (4.29±0.08 mg/dL; p<0.001). Serum γGT levels in the top quartile were associated with higher glycemia, overweight/obesity, increased levels of non-high-density lipoprotein (non-HDL) cholesterol, triglycerides, alanine aminotransferase, alkaline phosphatase, uric acid, creatinine, and hemoglobin. Levels of uric acid in the top quartile were associated with overweight/obesity, elevated non-HDL cholesterol, triglycerides, creatinine, γGT and hemoglobin. Higher arterial blood pressure was associated with high levels of uric acid but not with γGT levels. Conclusions: At high altitude, increased γGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease.
dc.language.iso eng
dc.publisher De Gruyter
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject hemoglobin
dc.subject high altitude
dc.subject Aged
dc.subject Middle Aged
dc.subject Altitude
dc.subject hypertension
dc.subject Obesity
dc.subject Overweight
dc.subject obesity
dc.subject altitude
dc.subject human
dc.subject Hypertension
dc.subject adult
dc.subject aged
dc.subject female
dc.subject male
dc.subject middle aged
dc.subject Article
dc.subject kidney disease
dc.subject pathophysiology
dc.subject blood
dc.subject metabolism
dc.subject biological marker
dc.subject Hemoglobins
dc.subject blood sampling
dc.subject hyperglycemia
dc.subject dyslipidemia
dc.subject Dyslipidemias
dc.subject high density lipoprotein cholesterol
dc.subject triacylglycerol
dc.subject cholesterol blood level
dc.subject glucose
dc.subject glucose blood level
dc.subject triacylglycerol blood level
dc.subject uric acid
dc.subject uric acid blood level
dc.subject hemoglobin blood level
dc.subject creatinine
dc.subject Hyperglycemia
dc.subject creatinine blood level
dc.subject kidney function
dc.subject alanine aminotransferase
dc.subject alanine aminotransferase blood level
dc.subject alkaline phosphatase
dc.subject alkaline phosphatase blood level
dc.subject arterial blood pressure
dc.subject arterial pressure
dc.subject Biological Markers
dc.subject gamma glutamyl transferase blood level
dc.subject gamma glutamyltransferase
dc.subject gamma-Glutamyltransferase
dc.subject hyperuricemia
dc.subject Kidney Diseases
dc.subject liver function
dc.subject Uric Acid
dc.subject venous blood
dc.subject γ-glutamyltransferase
dc.title Increased levels of serum γ-glutamyltransferase and uric acid on metabolic, hepatic and kidney parameters in subjects at high altitudes
dc.type info:eu-repo/semantics/article
dc.identifier.journal Journal of Basic and Clinical Physiology and Pharmacology


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