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Effectiveness of a malaria surveillance strategy based on active case detection during high transmission season in the Peruvian Amazon

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dc.contributor.author Moreno-Gutierrez, Diamantina
dc.contributor.author Llanos-Cuentas, Alejandro
dc.contributor.author Luis Barboza, Jose
dc.contributor.author Contreras-Mancilla, Juan
dc.contributor.author Gamboa, Dionicia
dc.contributor.author Rodriguez, Hugo
dc.contributor.author Carrasco-Escobar, Gabriel
dc.contributor.author Boreux, Raphael
dc.contributor.author Hayette, Marie-Pierre
dc.contributor.author Beutels, Philippe
dc.contributor.author Speybroeck, Niko
dc.contributor.author Rosas-Aguirre, Angel
dc.date.accessioned 2019-03-05T15:23:27Z
dc.date.available 2019-03-05T15:23:27Z
dc.date.issued 2018
dc.identifier.uri http://doi.org/10.3390/ijerph15122670
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5879
dc.description.abstract Background: Faced with the resurgence of malaria, malaria surveillance in the Peruvian Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy (LM) as reactive measure in communities with an unusual high number of cases during high transmission season (HTS). We assessed the effectiveness in malaria detection of this local ACD-based strategy. Methods: A cohort study was conducted in June–July 2015 in Mazan, Loreto. Four consecutive ACD interventions at intervals of 10 days were conducted in four riverine communities (Gamitanacocha, Primero de Enero, Libertad and Urco Miraño). In each intervention, all inhabitants were visited at home, and finger-prick blood samples collected for immediate diagnosis by LM and on filter paper for later analysis by quantitative real-time polymerase chain reaction (qPCR). Effectiveness was calculated by dividing the number of malaria infections detected using LM by the number of malaria infections detected by delayed qPCR. Results: Most community inhabitants (88.1%, 822/933) were present in at least one of the four ACD interventions. A total of 451 infections were detected by qPCR in 446 participants (54.3% of total participants); five individuals had two infections. Plasmodium vivax was the predominant species (79.8%), followed by P. falciparum (15.3%) and P. vivax-P. falciparum co-infections (4.9%). Most qPCR-positive infections were asymptomatic (255/448, 56.9%). The ACD-strategy using LM had an effectiveness of 22.8% (detection of 103 of the total qPCR-positive infections). Children aged 5–14 years, and farming as main economic activity were associated with P. vivax infections. Conclusions: Although the ACD-strategy using LM increased the opportunity of detecting and treating malaria infections during HTS, the number of detected infections was considerably lower than the real burden of infections (those detected by qPCR).
dc.language.iso eng
dc.publisher MDPI
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru
dc.subject Active case detection
dc.subject Plasmodium falciparum
dc.subject Plasmodium vivax
dc.subject Malaria
dc.subject asymptomatic infection
dc.subject human
dc.subject adult
dc.subject female
dc.subject male
dc.subject young adult
dc.subject Article
dc.subject cohort analysis
dc.subject socioeconomics
dc.subject microscopy
dc.subject controlled study
dc.subject major clinical study
dc.subject adolescent
dc.subject malaria
dc.subject child
dc.subject nonhuman
dc.subject preschool child
dc.subject Diagnosis
dc.subject blood sampling
dc.subject mixed infection
dc.subject real time polymerase chain reaction
dc.subject population research
dc.subject malaria falciparum
dc.subject parasite transmission
dc.subject Plasmodium vivax malaria
dc.subject disease surveillance
dc.subject school child
dc.subject quantitative diagnosis
dc.subject seasonal variation
dc.subject community program
dc.subject chloroquine
dc.subject agricultural worker
dc.subject program effectiveness
dc.subject primaquine
dc.subject artesunate
dc.subject mefloquine
dc.subject Asymptomatic
dc.subject community sample
dc.title Effectiveness of a malaria surveillance strategy based on active case detection during high transmission season in the Peruvian Amazon
dc.type info:eu-repo/semantics/article
dc.identifier.journal International Journal of Environmental Research and Public Health

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