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Antidepressant and antipsychotic-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa

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dc.contributor.author Tácuna-Calderón, Ana
dc.contributor.author Huaccho-Rojas, Juan Jesus
dc.contributor.author Zimic-Zare, Carolina
dc.contributor.author Pante-Medina, Carlos
dc.contributor.author Salazar-Granara, Alberto
dc.date.accessioned 2019-03-05T15:23:29Z
dc.date.available 2019-03-05T15:23:29Z
dc.date.issued 2018
dc.identifier.uri http://doi.org/10.5530/pj.2018.6s.6
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/5893
dc.description.abstract Introduction: Maytenus macrocarpa (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent. Also, chuchuhuasi is known as a master plant, attributing to it properties in the central nervous system. In addition, depression is a disorder of the mood that cause disability to millions of people around the world. For this reason, the aim of this study was to determinate the antidepressant and antipsychotic-like activity of the ethanolic extract of Maytenus macrocarpa. Methods: It was used the ethanolic extract of the leaves of Maytenus macrocarpa (EELMM) in female mice at the experimental model of the Forced Swim Test described by Porsolt. As control, it was used distillate water, fluoxetine and haloperidol. Results: The immobility time of the groups of EELMM has a mean of 38.26 ± 21.57, 84.32 ± 26.68 and 32.17 ± 25.55 for the doses of 750, 1000 and 1250 mg/Kg respectively; and the immobility time had a median of 7.5 [4.07 - 20.3] and 20.93 ± [17.63 - 23.75] for the doses of 500 mg/Kg and 1500 mg/Kg. It was seen a positive dose-response between the dose of 500 to 1000 mg/Kg (Pearson correlation of r=0.8339 and R=0.6954) and a negative dose-response between the dose of 1000 to 1500 mg/Kg. (Pearson correlation of r= -0.7590 and R= 0.5760). Conclusion: It was demonstrated the antidepressant-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa with a dose of 500 mg/kg and an antipsychotic-like activity with a dose of 1000 mg/kg.
dc.language.iso eng
dc.publisher Emanuscript Services
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject water
dc.subject female
dc.subject Article
dc.subject depression
dc.subject Depression
dc.subject controlled study
dc.subject animal experiment
dc.subject animal model
dc.subject nonhuman
dc.subject unclassified drug
dc.subject mouse
dc.subject plant extract
dc.subject drug dose comparison
dc.subject dose response
dc.subject plant leaf
dc.subject antidepressant agent
dc.subject double blind procedure
dc.subject forced swim test
dc.subject Maytenus
dc.subject fluoxetine
dc.subject neuroleptic agent
dc.subject Fluoxetine
dc.subject tranquilizing activity
dc.subject haloperidol
dc.subject antidepressant activity
dc.subject Chuchuhuasi
dc.subject distillation
dc.subject Forced swim test
dc.subject Haloperidol
dc.subject immobility time
dc.subject Maytenus macrocarpa
dc.subject Maytenus macrocarpa extract
dc.title Antidepressant and antipsychotic-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa
dc.type info:eu-repo/semantics/article
dc.identifier.journal Pharmacognosy Journal

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