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Neurocysticercosis: A natural human model of epileptogenesis

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dc.contributor.author Nash, T.E.
dc.contributor.author Mahanty, S.
dc.contributor.author Loeb, J.A.
dc.contributor.author Theodore, W.H.
dc.contributor.author Friedman, A.
dc.contributor.author Sander, J.W.
dc.contributor.author Singh, G.
dc.contributor.author Cavalheiro, E.
dc.contributor.author Del Brutto, O.H.
dc.contributor.author Takayanagui, O.M.
dc.contributor.author Fleury, A.
dc.contributor.author Verastegui, M.
dc.contributor.author Preux, P.-M.
dc.contributor.author Montano, S.
dc.contributor.author Pretell, E.J.
dc.contributor.author White, A.C. Jr.
dc.contributor.author Gonzales, A.E.
dc.contributor.author Gilman, R.H.
dc.contributor.author Garcia, H.H.
dc.date.accessioned 2019-04-25T15:46:36Z
dc.date.available 2019-04-25T15:46:36Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.1111/epi.12849
dc.identifier.uri http://repositorio.upch.edu.pe/handle/upch/6531
dc.description.abstract Objective To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. Methods A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. Results Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. Significance Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state. © Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.
dc.language.iso eng
dc.publisher Wiley
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject anticonvulsive agent
dc.subject antiparasitic agent
dc.subject animal model
dc.subject Article
dc.subject blood brain barrier
dc.subject brain calcification
dc.subject brain cyst
dc.subject cestode life cycle stage
dc.subject clinical trial (topic)
dc.subject disease course
dc.subject disease duration
dc.subject disease model
dc.subject disease severity
dc.subject drug identification
dc.subject drug targeting
dc.subject epilepsy
dc.subject epileptogenesis
dc.subject human
dc.subject inflammation
dc.subject neurocysticercosis
dc.subject nonhuman
dc.subject priority journal
dc.subject randomized controlled trial (topic)
dc.subject seizure
dc.subject taeniasis
dc.subject animal
dc.subject brain edema
dc.subject complication
dc.subject epilepsy
dc.subject granuloma
dc.subject isolation and purification
dc.subject microbiology
dc.subject neurocysticercosis
dc.subject pathology
dc.subject pathophysiology
dc.subject Taenia solium
dc.subject Animals
dc.subject Blood-Brain Barrier
dc.subject Brain Edema
dc.subject Epilepsy
dc.subject Granuloma
dc.subject Humans
dc.subject Neurocysticercosis
dc.subject Taenia solium
dc.title Neurocysticercosis: A natural human model of epileptogenesis
dc.type info:eu-repo/semantics/article
dc.identifier.journal Epilepsia


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