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Browsing by Author "Deharo, E."

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Activity-guided isolation of antileishmanial compounds from Piper hispidum

Ruiz, C.; Haddad, M.; Alban, J.; Bourdy, G.; Reategui, R.; Castillo Pareja, Denis Helan; Sauvain, Michel Henri Auguste; Deharo, E.; Estevez, Y.; Arévalo Zelada, Jorge Luis; Rojas, R. (Elsevier, 2011)

The bioassay-guided purification of the ethanolic extract from the leaves of Piper hispidum led to the isolation of one new amide, N-2-(3′,4′, 5′-trimethoxyphenyl)ethyl-2-hydroxybenzamide (1) as well as two known chalcones ...
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark

Rojas-Duran, R.; González-Aspajo, G.; Ruiz-Martel, C.; Bourdy, G.; Doroteo-Ortega, V.H.; Alban-Castillo, J.; Robert, G.; Auberger, P.; Deharo, E. (Elsevier, 2012)

Ethnopharmacological relevance: Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) is widely used by populations living in South America to treat many ailments associated with inflammatory disorders. Mitraphylline ...
Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships

Mendoza, A.; Pérez-Silanes, S.; Quiliano, M.; Pabón, A.; Galiano, S.; González, G.; Garavito, G.; Zimic-Peralta, Mirko Juan; Vaisberg Wollach, Abraham Jaime; Aldana, I.; Monge, A.; Deharo, E. (Elsevier, 2011)

Piperazine and pyrrolidine derivatives were synthesised and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture. The combined presence of a hydroxyl ...
Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H- pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2- pyridinylamine derivatives as c-Met kinase inhibitors

Caballero, J.; Quiliano, M.; Alzate-Morales, J.H.; Zimic-Peralta, Mirko Juan; Deharo, E. (Springer, 2011)

We have performed docking of 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4- yloxy)aniline (FPTA), 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (FPPA), and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine (AFPP) derivatives ...
New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae)

Bertani, S.; Houël, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. (Elsevier, 2012)

Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown ...
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

Barea, C.; Pabón, A.; Castillo Pareja, Denis Helan; Zimic-Peralta, Mirko Juan; Quiliano, M.; Galiano, S.; Pérez-Silanes, S.; Monge, A.; Deharo, E.; Aldana, I. (Elsevier, 2011)

Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2- carbonitrile derivatives were synthesized and evaluated for their in vitro ...
Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives

Estevez, Y.; Quiliano, M.; Burguete, A.; Cabanillas Amado, Billy Joel; Zimic-Peralta, Mirko Juan; Málaga, E.; Verastegui Pimentel, Manuela Renee; Pérez-Silanes, S.; Aldana, I.; Monge, A.; Castillo Pareja, Denis Helan; Deharo, E. (Elsevier, 2011)

Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania peruviana and Trypanosoma cruzi. Both series were tested for toxicity against proliferative and non-proliferative cells. ...

Browsing by Author "Deharo, E."

Browsing by Author "Deharo, E."

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