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Browsing by Author "Kariyawasam, R."

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Influence of Leishmania RNA Virus 1 on Proinflammatory Biomarker Expression in a Human Macrophage Model of American Tegumentary Leishmaniasis

Kariyawasam, R.; Grewal, J.; Lau, R.; Purssell, A.; Valencia, B. M.; Llanos Cuentas, Elmer Alejandro; Boggild, A. K. (Oxford University Press, 2017)

Backgound. Species of the Leishmania Viannia (L. V.) subgenus harbor the double-stranded Leishmania RNA virus 1 (LRV-1), previously identified in isolates from Brazil and Peru. Higher levels of LRV-1 in metastasizing strains ...
Influence of Leishmania RNA Virus-1 (LRV-1) on Virulence Factor RNA Transcript Expression of Leishmania Viannia spp

Kariyawasam, R.; Mukkala, A.; Lau, R.; Valencia, B.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (Elsevier, 2018)

Background: Leishmania RNA Virus-1 (LRV-1) is a double stranded RNA virus identified in strains of the Viannia subgenus in Latin America. Virulence factors (VFs) are gene products that augment pathogenicity of an organism, ...
Point-of-Care Molecular Diagnosis of Cutaneous Leishmaniasis and Intercurrent Fungal and Mycobacterial Infections

Valencia, B.; Lau, R.; Kariyawasam, R.; Shao, E.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (Elsevier, 2018)

Background: Due to the highly toxic nature of standard drugs used in the treatment of cutaneous leishmaniasis (CL), and overlapping clinical features of CL with ulcers due to fungal and mycobacterial infections, confirmatory ...
Prevalence and Association of Leishmania RNA Virus-1 (LRV-1) in Severe and Non-Severe Phenotypes of American Tegumentary Leishmaniasis from Peru

Kariyawasam, R.; Lau, R.; Valencia, B.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (Elsevier, 2018)

Background: American tegumentary leishmaniasis (ATL) comprises a discrete set of clinical presentations of leishmaniasis endemic to Latin America and particularly Peru. Leishmania RNA virus-1 (LRV-1) is a double stranded ...
Spectrum of Bacterial Pathogens in Inflammatory and Non-Inflammatory Ulcers of American Cutaneous Leishmaniasis

Kariyawasam, R.; Gascon, B.; Mah, J.; Lau, R.; Valencia, B.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (Elsevier, 2018)

Background: Cutaneous leishmaniasis (CL) may present with an inflammatory phenotype, characterized by pain, erythema, and purulent exudate, which is typically treated with antibiotics prior to anti-Leishmania treatment. ...
Virulence Factor RNA Transcript Expression in Cultured Clinical Isolates of Leishmania Does Not Vary by Host Age

Mukkala, A.; Kariyawasam, R.; Lau, R.; Valencia, B.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (Elsevier, 2018)

Background: Virulence factors (VF) are endogenous molecules that often enhance the pathogenicity of an organism. The role of host age on the immunopathogenesis of leishmaniasis is poorly understood. Despite pediatric ...
Virulence factor RNA transcript expression in the Leishmania Viannia subgenus: Influence of species, isolate source, and Leishmania RNA virus-1

Kariyawasam, R.; Mukkala, A.N.; Lau, R.; Valencia, B.M.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (Springer, 2019)

Background: Leishmania RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20-25% of Viannia - species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time. Our ...

Browsing by Author "Kariyawasam, R."

Browsing by Author "Kariyawasam, R."

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