Browsing by Author "Llerena, Adrian"

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Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans

Rodrigues-Soares, Fernanda; Penas-Lledo, Eva M.; Tarazona-Santos, Eduardo; Sosa-Macias, Martha; Teran, Enrique; Lopez-Lopez, Marisol; Rodeiro, Idania; Moya, Graciela E.; Calzadilla, Luis R.; Ramirez-Roa, Ronald; Grazina, Manuela; Estevez-Carrizo, Francisco E.; Barrantes, Ramiro; Llerena, Adrian (Wiley, 2019)

We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ...
Population genetics of PDE4B (Phosphodiesterase-4B) in neglected native americans: implications for cancer pharmacogenetics.

Moreira, Rennan Garcias; Saraiva-Duarte, Julia Maria; Pereira, Alexandre Costa; Sosa-Macias, Martha; Galaviz-Hernandez, Carlos; Santolalla Robles, Meddly Leslye; Magalhaes, Wagner C. S.; Zolini, Camila; Leal, Thiago Peixoto; Balazs, Zsolt; Llerena, Adrian; Gilman, Robert Hugh; Mill, Jose Geraldo; Borda, Victor; Guio, Heinner; O'Connor, Timothy D.; Tarazona-Santos, Eduardo; Rodrigues-Soares, Fernanda (Wiley, 2022)

PDE4B (phosphodiesterase-4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic ...

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