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Browsing by Author "O'Neal, Seth E."

Browsing by Author "O'Neal, Seth E."

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  • Apuntes y recomendaciones para el establecimiento de programas de control de la teniasis / cisticercosis por Taenia solium en el Perú 
    García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano; O'Neal, Seth E.; Gilman, Robert Hugh (Instituto Nacional de Salud, 2018)
    Neurocysticercosis is the infection of the nervous system by the larvae (cysticerci) of the pork tapeworm Taenia solium. Neurocysticercosis is the major cause of acquired epilepsy worldwide and as such, it represents a ...
  • Assessing Ultrasonography as a Diagnostic Tool for Porcine Cysticercosis 
    Flecker, Robert H.; Pray, Ian W.; Santivanez, Saul J.; Ayvar, Viterbo; Gamboa Morán, Ricardo; Muro Ecca, Claudio Alberto; Moyano, Luz Maria; Benavides, Victor; García Lescano, Héctor Hugo; O'Neal, Seth E. (Public Library of Science, 2017)
    BACKGROUND: Taenia solium inflicts substantial neurologic disease and economic losses on rural communities in many developing nations. "Ring-strategy" is a control intervention that targets treatment of humans and pigs ...
  • Barriers to participation in a community-based program to control transmission of Taenia solium in Peru 
    Beam, Michelle; Spencer, Angela; Fernandez, Lauralee; Atto, Ruth; Muro Ecca, Claudio Alberto; Vilchez Barreto, Percy Mcquen; Gamboa Morán, Ricardo; Olaya, Sandra; Ayvar, Viterbo; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; O'Neal, Seth E.; Cysticercosis Working Group in Peru (American Society of Tropical Medicine and Hygiene, 2018)
    Infection of the brain with Taenia solium larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities ...
  • Clinical Characteristics of Neurocysticercosis in a Peruvian Population-Based Epilepsy Cohort: A Descriptive Cross-Sectional Study of Baseline Clinical Intake. 
    Allen, Samantha E.; Moyano Vidal, Luz Maria; Wardle, Melissa T.; Guzman, Carolina; Sanchez-Boluarte, Sofia S.; Bonnet, Gabrielle; Bustos Palomino, Javier Arturo; O'Neal, Seth E.; García Lescano, Héctor Hugo (MDPI, 2023)
    Background: This study presents the baseline characteristics of a community-level population of people with epilepsy (n = 1975) living in an area endemic for Taenia solium, the pathogen responsible for neurocysticercosis ...
  • Clustering of Necropsy-Confirmed Porcine Cysticercosis Surrounding Taenia solium Tapeworm Carriers in Peru 
    Lescano Guevara, Andres Guillermo; Pray, I.W.; Gonzalez Zariquiey, Armando Emiliano; Gilman, Robert Hugh; Tsang, V.C.W.; Gamboa Morán, Ricardo; Guezala, M.C.; Aybar, V.; Rodriguez, S.; Moulton, L.H.; Leontsini, E.; Gonzalvez, G.; O'Neal, Seth E.; García Lescano, Héctor Hugo (American Society of Tropical Medicine and Hygiene, 2019)
    The pork tapeworm, Taenia solium, is among the leading causes of preventable epilepsy in the world and is common in rural areas of developing countries where sanitation is limited and pigs have access to human feces. Prior ...
  • Consistent Measurement of Parasite-Specific Antigen Levels in Sera of Patients with Neurocysticercosis Using Two Different Monoclonal Antibody (mAb)-Based Enzyme-Linked Immunosorbent Assays. 
    Castillo Berrios, Yesenia; Toribio Salazar, Luz Milagros; Guzmán Dueñas, Carolina del Rosario; Arroyo Hurtado, Gianfranco; Espinoza Guerrero, Cindy; Saavedra, Herbert; Bustos Palomino, Javier Arturo; Dorny, Pierre; O'Neal, Seth E.; García Lescano, Héctor Hugo (MDPI, 2023)
    Monoclonal antibody (mAb)-based enzyme-linked immunosorbent assay (ELISA) is a complementary diagnosis technique for neurocysticercosis (NCC), which detects circulating parasite antigen (Ag) indicative of viable infection ...
  • Development and Laboratory Evaluation of a Simple, Field-Applicable Coproantigen Enzyme-Linked Immunosorbent Assay for Diagnosis of Taeniasis in Northern Peru. 
    Castillo Berrios, Yesenia; Wardle, Melissa T.; Gamboa Morán, Ricardo; Elizalde Pizarro, Mayra Yajayra; Vilchez Barreto, Percy Mcquen; Rodriguez, Silvia; Gilman, Robert H.; Gonzalez, Armando E.; O'Neal, Seth E.; García Lescano, Héctor Hugo (American Society for Microbiology, 2023)
    Coproantigen detection by enzyme-linked immunosorbent assay (coAg ELISA) is a vital tool for detecting and treating cases of Taenia solium taeniasis. However, the assay's procedures require costly materials and sophisticated ...
  • Development of a dose-response model for porcine cysticercosis 
    Andrade-Mogrovejo, Daniel A.; Gonzales-Gustavson, Eloy; Ho-Palma, Ana C.; Prada, Joaquin M.; Bonnet, Gabrielle; Pizzitutti, Francesco; Gomez-Puerta, Luis A.; Arroyo Hurtado, Gianfranco; O'Neal, Seth E.; García Lescano, Héctor Hugo; Guitian, Javier; Gonzalez Zariquiey, Armando Emiliano (Public Library of Science, 2022)
    Taenia solium is an important cause of acquired epilepsy worldwide and remains endemic in Asia, Africa, and Latin America. Transmission of this parasite is still poorly understood despite the design of infection experiments ...
  • Elimination of Taenia solium Transmission in Northern Peru 
    García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano; Tsang, Victor C. W.; O'Neal, Seth E.; Llanos Zavalaga, Luis Fernando; Gonzalvez, Guillermo; Romero, Jaime; Rodriguez, Silvia; Moyano, Luz M.; Ayvar, Viterbo; Diaz, Andre; Hightower, Allen; Craig, Philip S.; Lightowlers, Marshall W.; Gauci, Charles G.; Leontsini, Elli; Gilman, Robert Hugh (Massachusetts Medical Society, 2016)
    BACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, ...
  • Elimination of Taenia solium Transmission in Peru 
    García Lescano, Héctor Hugo; O'Neal, Seth E.; Gilman, Robert Hugh (Massachusetts Medical Society, 2016)
    Garcia et al. (June 16 issue) conclude that the transmission of taeniasis and cysticercosis was interrupted in a region in which these diseases are endemic owing to mass drug administration in humans and pigs. We are not ...
  • Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study. 
    Gonzales-Gustavson, Eloy; Pray, Ian W.; Gamboa Morán, Ricardo; Muro Ecca, Claudio Alberto; Vilchez Barreto, Percy Mcquen; Gomez-Puerta, Luis; Vargas-Calla, Ana; Bonnet, Gabrielle; Pizzitutti, Francesco; García Lescano, Héctor Hugo; Gonzalez, Armando E.; O'Neal, Seth E. (MDPI, 2023)
    The widespread dispersion of pigs infected with cysticercosis across endemic villages, low cyst burden among infected pigs, and low prevalence of taeniasis all suggest that pig ingestion of human feces is not the only ...
  • Evaluating Urban Taeniasis as a Threat to Cysticercosis Elimination in Northern Peru 
    Fernandez, Lauralee; Gamboa Morán, Ricardo; Vilchez Barreto, Percy Mcquen; Pray, Ian; Beam, Michelle; Garvey, Brian; Spencer, Angela; Atto, Ruth; Muro Ecca, Claudio Alberto; Moyano, Luz Maria; García Lescano, Héctor Hugo; O'Neal, Seth E.; Cysticercosis Working Group in Peru (American Society of Tropical Medicine and Hygiene, 2019)
    Reintroduction of Taenia solium into a region in Peru where it had been eliminated prompted evaluation of the possibility of reintroduction from an urban reservoir of taeniasis. In a cross-sectional study of an adjacent ...
  • Evaluation of cross-reactivity to Taenia hydatigena and Echinococcus granulosus in the enzyme-linked immunoelectrotransfer blot assay for the diagnosis of porcine cysticercosis 
    Gomez-Puerta, Lucho; Vargas-Calla, Ana; Castillo Berrios, Yesenia; Lopez-Urbina, Maria Teresa; Dorny, Pierre; García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano; O'Neal, Seth E. (BioMed Central, 2019)
    BACKGROUND: Taenia solium is an important zoonotic parasite that infects humans as definitive host (taeniasis) and pigs as intermediate host (cysticercosis). Serological diagnosis of porcine cysticercosis is limited to ...
  • Feasibility of a point-of-care test based on quantum dots with a mobile phone reader for detection of antibody responses. 
    Lee, Chan; Noh, John; O'Neal, Seth E.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; Handali, Sukwan (Public Library of Science, 2019)
    We developed a novel and portable fluorescent sensor that integrates a lateral flow assay with a quantum dot (Qdots) label and a mobile phone reader for detection of specific antibodies in human serum. We evaluated the ...
  • Frequency and determinant factors for calcification in neurocysticercosis 
    Bustos Palomino, Javier Arturo; Arroyo Hurtado, Gianfranco; Gilman, Robert Hugh; Soto Becerra, Percy; Gonzales, Isidro; Saavedra Pastor, Herbert; Pretell, E. Javier; Nash, Theodore E.; O'Neal, Seth E.; Del Brutto, Oscar H.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; Cysticercosis Working Group in Peru (Oxford University Press, 2021)
    BACKGROUND: Neurocysticercosis is a major cause of acquired epilepsy. Larval cysts in the human brain eventually resolve and either disappear or leave a calcification that is associated with seizures. In this study, we ...
  • Geographic Correlation between Tapeworm Carriers and Heavily Infected Cysticercotic Pigs 
    O'Neal, Seth E.; Moyano, L.M.; Ayvar, V.; Gonzalvez, G.; Diaz, A.; Rodriguez, S.; Wilkins, P.P.; Tsang, V.C.W.; Gilman, Robert Hugh; García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano (Public Library of Science, 2012)
    Background: Neurocysticercosis is a leading cause of preventable epilepsy in the developing world. Sustainable community-based interventions are urgently needed to control transmission of the causative parasite, Taenia ...
  • Geographically targeted interventions versus mass drug administration to control Taenia solium cysticercosis, Peru 
    O'Neal, Seth E.; Pray, I.W.; Vilchez Barreto, Percy Mcquen; Gamboa Morán, Ricardo; Muro Ecca, Claudio Alberto; Moyano, L.M.; Ayvar, V.; Gavidia, C.M.; Gilman, Robert Hugh; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; Cysticercosis Working Group in Peru (Centers for Disease Control and Prevention, 2021)
    Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention ...
  • GPS Tracking of Free-Ranging Pigs to Evaluate Ring Strategies for the Control of Cysticercosis/Taeniasis in Peru 
    Pray, Ian-W.; Swanson, Dallas-J.; Ayvar, Viterbo; Muro Ecca, Claudio Alberto; Moyano, Luz-M.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; O'Neal, Seth E. (Public Library of Science, 2016)
    BACKGROUND: Taenia solium, a parasitic cestode that affects humans and pigs, is the leading cause of preventable epilepsy in the developing world. T. solium eggs are released into the environment through the stool of humans ...
  • High Prevalence of Asymptomatic Neurocysticercosis in an Endemic Rural Community in Peru 
    Moyano, Luz M.; O'Neal, Seth E.; Ayvar, Viterbo; Gonzalvez, Guillermo; Gamboa Morán, Ricardo; Vilchez Barreto, Percy Mcquen; Rodriguez, Silvia; Reistetter, Joe; Tsang, Victor C. W.; Gilman, Robert Hugh; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo (Public Library of Science, 2016)
    BACKGROUND: Neurocysticercosis is a common helminthic infection of the central nervous system and an important cause of adult-onset epilepsy in endemic countries. However, few studies have examined associations between ...
  • Improved diagnosis of viable parenchymal neurocysticercosis by combining antibody banding patterns on enzyme-linked immunoelectrotransfer blot (EITB) with antigen ELISA assay. 
    Arroyo Hurtado, Gianfranco; Bustos Palomino, Javier Arturo; Lescano Guevara, Andres Guillermo; Gonzales, Isidro; Saavedra Pastor, Herbert; Pretell, E. Javier; Castillo Berrios, Yesenia; Perez, Erika; Handali, Sukwan; Noh, John; Dorny, Pierre; Gilman, Robert Hugh; O'Neal, Seth E.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo (American Society for Microbiology, 2022)
    The diagnosis of neurocysticercosis (NCC) depends on neuroimaging and serological confirmation. While antibody detection by enzyme-linked immunoelectrotransfer blot (EITB) fails to predict viable NCC, EITB banding patterns ...

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