Browsing by Subject "Amyloid beta-Peptides/metabolism"

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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of

Sempou, Emily; Biasini, Emiliano; Pinzon-Olejua, Alejandro; Harris, David-A.; Málaga Trillo, George Edward (Springer, 2016)

BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease

Málaga Trillo, George Edward; Ochs, Katharina (Taylor and Francis, 2016)

Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a ...

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