Browsing by Subject "Bacterial Proteins/genetics"

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dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains

Moradigaravand, Danesh; Grandjean, Louis; Martinez, Elena; Li, Hao; Zheng, Jun; Coronel, Jorge; Moore, David Alexander James; Torok, M. Estee; Sintchenko, Vitali; Huang, Hairong; Javid, Babak; Parkhill, Julian; Peacock, Sharon-J.; Koser, Claudio-U. (American Society for Microbiology, 2016)

Para-Aminosalicylic acid (PAS) is a group 4 antituberculosis agent. It targets folate metabolism as shown in Fig. S1 in the supplemental material, which also summarizes the known mechanisms of resistance to this prodrug. ...

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