Browsing by Subject "Mutaciones Compensatorias"

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Determination of potentially novel compensatory mutations in rpoC associated with rifampin resistance and rpoB mutations in Mycobacterium tuberculosis clinical isolates from Peru

Vargas Ruiz, Ana Paula (Universidad Peruana Cayetano HerediaPE, 2020)

Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations ...
Potenciales mutaciones compensatorias asociadas a la resistencia a rifampicina en Mycobacterium tuberculosis

Rabanal Sanchez, Jhonatan (Universidad Peruana Cayetano HerediaPE, 2020)

Aproximadamente más del 95% de los casos de resistencia a rifampicina en Mycobacterium tuberculosis se deben a mutaciones en el gen rpoB. Dichas mutaciones producen efectos nocivos en las bacterias (disminuyen su fitness). ...

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