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Browsing by Subject "erythropoiesis"

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Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis

Schuler, B.; Vogel, J.; Grenacher, B.; Jacobs, R.A.; Arras, M.; Gassmann, M. (Wiley, 2012)

Application of recombinant human erythropoietin (rhEpo) improves exercise capacity by stimulating red blood cell production that, in turn, enhances oxygen delivery and utilization. Apart from this, when applied at high ...
HIF-1α is a protective factor in conditional PHD2-βdeficient mice suffering from severe HIF-2-induced excessive erythropoiesis

Franke, Kristin; Kalucka, Joanna; Mamlouk, Soulafa; Singh, Rashim Pal; Muschter, Antje; Weidemann, Alexander; Iyengar, Vasuprada; Jahn, Steffen; Wieczorek, Kathrin; Geiger, Kathrin; Muders, Michaels; Sykes, Alex M.; Poitz, David M.; Ripich, Tatsiana; Otto, Teresa; Bergmann, Sybille; Breier, Georg; Baretton, Gustavo; Fong, Guo-Hua; Greaves, David R.; Bornstein, Stefan; Chavakis, Triantafyllos; Joachim Fandrey, Max Gassmann; Wielockx, Ben (Elsevier, 2013)

Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible ...
Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with Chronic Mountain Sickness.

Bermudez, Daniela; Azad, Priti; Figueroa-Mujica, Romulo; Vizcardo-Galindo, Gustavo; Corante, Noemi; Guerra-Giraldez, Cristina; Haddad, Gabriel G.; Villafuerte, Francisco C. (American Physiological Society, 2019)

Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE ...
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice

Díaz, Víctor; Gammella, Elena; Recalcati, Stefania; Santambrogio, Paolo; Naldi, Arianne Monge; Vogel, Johannes; Gassmann, Max; Cairo, Gaetano (Wiley, 2013)

The liver-derived peptide hepcidin controls the balance between iron demand and iron supply. By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores. ...
Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation

Dey, Soumyadeep; Cui, Zhenzhong; Gavrilova, Oksana; Zhang, Xiaojie; Gassmann, Max; Noguchi, Constance T. (American Society for Clinical Investigation, 2020)

The blood hormone erythropoietin (EPO), upon binding to its receptor (EpoR), modulates high-fat diet-induced (HFO-induced) obesity in mice, improves glucose tolerance, and prevents white adipose tissue inflammation. ...

Browsing by Subject "erythropoiesis"

Browsing by Subject "erythropoiesis"

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