Browsing by Subject "gene dosage"

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Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains

Reis-Cunha, J.L.; Rodrigues-Luiz, G.F.; Valdivia, H.O.; Baptista, R.P.; Mendes, T.A.O.; Loss de Morais, G.; Guedes, R.; Macedo, A.M.; Bern, C.; Gilman, Robert Hugh; Talavera Lopez, C.; Andersson, B.; Vasconcelos, A.T.; Bartholomeu, D.C. (BioMed Central, 2015)

Background: Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. CL Brener, the reference strain of the T. cruzi genome project, is a hybrid ...
Incidence of virological failure and major regimen change of initial combination antiretroviral therapy in the Latin America and the Caribbean: An observational cohort study

Cesar, C.; Jenkins, C.A.; Shepherd, B.E.; Padgett, D.; Mejía Cordero, Fernando Alonso; Ribeiro, S.R.; Cortes, C.P.; Pape, J.W.; Sierra Madero, J.; Fink, V.; Sued, O.; McGowan, C.; Cahn, P.; Grinsztejn, B.; Reyes, M.W.; Gotuzzo Herencia, José Eduardo; CCASAnet (Elsevier, 2015)

Background: Access to combination antiretroviral therapy (ART) is expanding in Latin America (Mexico, Central America, and South America) and the Caribbean. We assessed the incidence of and factors associated with regimen ...

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