Browsing by Subject "zebrafish"

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CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

Kushawah, G.; Hernandez-Huertas, L.; Abugattas-Nuñez del Prado, J.; Martinez-Morales, J.R.; DeVore, M.L.; Hassan, H.; Moreno-Sanchez, I.; Tomas-Gallardo, L.; Diaz-Moscoso, A.; Monges, D.E.; Guelfo, J.R.; Theune, W.C.; Brannan, E.O.; Wang, W.; Corbin, T.J.; Moran, A.M.; Sánchez Alvarado, A.; Málaga Trillo, George Edward; Takacs, C.M.; Bazzini, A.A.; Moreno-Mateos, M.A. (Elsevier, 2020)

The development of mRNA knockdown technologies for use in vertebrate organisms such as zebrafish has been limited. Kushawah et al. establish CRISPR-RfxCas13d as an efficient, specific, cost-effective, and straightforward ...
Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease

Málaga Trillo, George Edward; Ochs, Katharina (Taylor and Francis, 2016)

Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a ...

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