Listar por tema "Amidohydrolases"

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  • Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds 
    Rueda, Daniel; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Bueno, Carlos; Santos, Marco; Pando-Robles, Victoria; Batista, Cesar V.; Zimic-Peralta, Mirko Juan (Elsevier, 2014)
    Recombinant wild-pyrazinamidase from H37Rv Mycobacterium tuberculosis was analyzed by gel electrophoresis under differential reducing conditions to evaluate its quaternary structure. PZAse was fractionated by size exclusion ...
  • Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase 
    Sheen Cortavarria, Patricia; Ferrer, P.; Gilman, Robert Hugh; Christiansen, G.; Moreno-Román, P.; Gutiérrez, A.H.; Sotelo, J.; Evangelista, W.; Fuentes, P.; Rueda, D.; Flores, M.; Olivera, P.; Solis, J.; Pesaresi, A.; Lamba, D.; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2012)
    Pyrazinamidase of Mycobacterium tuberculosis catalyzes the conversion of pyrazinamide to the active molecule pyrazinoic acid. Reduction of pyrazinamidase activity results in a level of pyrazinamide resistance. Previous ...

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