Listar por autor "Gallo López-Aliaga, Carla Maria"

Mostrando ítems 1-20 de 52

Página siguiente

ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in chileans

Boekstegers, Felix; Marcelain, Katherine; Barahona Ponce, Carol; Baez Benavides, Pablo F.; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, Maria Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; González Silos, Rosa; Fischer, Christine; Scherer, Dominique; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; Gonzalez-Jose, Rolando; Bedoya, Gabriel; Bortolini, Maria C.; Canizales, Samuel; Gallo López-Aliaga, Carla Maria; Ruiz Linares, Andres; Rothhammer, Francisco; Lorenzo Bermejo, Justo (Elsevier, 2020)

BACKGROUND: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. ...
Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals

Ruiz-Linares, Andrés; Adhikari, Kaustubh; Acuña-Alonzo, Victor; Quinto-Sanchez, Mirsha; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, María; Everardo, Paola; de Avila, Francisco; Gómez-Valdés, Jorge; León-Mimila, Paola; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Burley, Mari-Wyn; Konca, Esra; de Oliveira, Marcelo Zagonel; Veronez, Mauricio Roberto; Rubio-Codina, Marta; Attanasio, Orazio; Gibbon, Sahra; Ray, Nicolas; Gallo López-Aliaga, Carla Maria; Poletti, Giovanni; Rosique, Javier; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Balding, David; Gonzalez-José, Rolando (Public Library of Science, 2014)

The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social ...
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium

Fernández-Rhodes, L.; Graff, M.; Buchanan, V.L.; Justice, A.E.; Highland, H.M.; Guo, X.; Zhu, W.; Chen, H.-H.; Young, K.L.; Adhikari, K.; Palmer, N.D.; Below, J.E.; Bradfield, J.; Pereira, A.C.; Glover, L.S.; Kim, D.; Lilly, A.G.; Shrestha, P.; Thomas, A.G.; Zhang, X.; Chen, M.; Chiang, C.W.K.; Pulit, S.; Horimoto, A.; Krieger, J.E.; Guindo-Martínez, M.; Preuss, M.; Schumann, C.; Smit, R.A.J.; Torres-Mejía, G.; Acuña-Alonzo, V.; Bedoya, G.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo López-Aliaga, Carla Maria; González-José, R.; Poletti, G.; Rothhammer, F.; Hakonarson, H.; Igo, R.; Adler, S.G.; Iyengar, S.K.; Nicholas, S.B.; Gogarten, S.M.; Isasi, C.R.; Papnicolaou, G.; Stilp, A.M.; Qi, Q.; Kho, M.; Smith, J.A.; Langefeld, C.D.; Wagenknecht, L.; Mckean-Cowdin, R.; Gao, X.R.; Nousome, D.; Conti, D.V.; Feng, Y.; Allison, M.A.; Arzumanyan, Z.; Buchanan, T.A.; Ida Chen, Y.-D.; Genter, P.M.; Goodarzi, M.O.; Hai, Y.; Hsueh, W.; Ipp, E.; Kandeel, F.R.; Lam, K.; Li, X.; Nadler, J.L.; Raffel, L.J.; Roll, K.; Sandow, K.; Tan, J.; Taylor, K.D.; Xiang, A.H.; Yao, J.; Audirac-Chalifour, A.; de Jesus Peralta Romero, J.; Hartwig, F.; Horta, B.; Blangero, J.; Curran, J.E.; Duggirala, R.; Lehman, D.E.; Puppala, S.; Fejerman, L.; John, E.M.; Aguilar-Salinas, C.; Burtt, N.P.; Florez, J.C.; García-Ortíz, H.; González-Villalpando, C.; Mercader, J.; Orozco, L.; Tusié-Luna, T.; Blanco, E.; Gahagan, S.; Cox, N.J.; Hanis, C.; Butte, N.F.; Cole, S.A.; Comuzzie, A.G.; Voruganti, V.S.; Rohde, R.; Wang, Y.; Sofer, T.; Ziv, E.; Grant, S.F.A.; Ruiz-Linares, A.; Rotter, J.I.; Haiman, C.A.; Parra, E.J.; Cruz, M.; Loos, R.J.F.; North, K.E. (Elsevier, 2022)

Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and ...
Automatic ear detection and feature extraction using Geometric Morphometrics and convolutional neural networks

Cintas, C.; Quinto-Sanchez, M.; Acuna, V.; Paschetta, C.; de Azevedo, S.; de Cerqueira, C. C. S.; Ramallo, V.; Gallo López-Aliaga, Carla Maria; Poletti, Giovanni; Bortolini, M. C.; Canizales-Quinteros, S.; Rothhammer, F.; Bedoya, G.; Ruiz-Linares, A.; Gonzalez-Jose, R.; Delrieux, C. (Wiley, 2016)

Accurate gathering of phenotypic information is a key aspect in several subject matters, including biometrics, biomedical analysis, forensics, and many other. Automatic identification of anatomical structures of biometric ...
Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Li, Qing; Chen, Jieyi; Faux, Pierre; Delgado, Miguel Eduardo; Bonfante, Betty; Fuentes-Guajardo, Macarena; Mendoza Revilla, Javier Alberto; Chacón-Duque, J. Camilo; Hurtado Chiong, Gloria Malena; Villegas Bernaola, Valeria; Granja Burbano, Vanessa Patricia; Jaramillo, Claudia; Arias, William; Barquera, Rodrigo; Everardo-Martínez, Paola; Sánchez-Quinto, Mirsha; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Silva de Cerqueira, Caio C.; Hünemeier, Tábita; Ramallo, Virginia; Wu, Sijie; Du, Siyuan; Giardina, Andrea; Paria, Soumya Subhra; Khokan, Mahfuzur Rahman; Gonzalez-José, Rolando; Schüler-Faccini, Lavinia; Bortolini, Maria-Cátira; Acuña-Alonzo, Victor; Canizales-Quinteros, Samuel; Gallo López-Aliaga, Carla Maria; Poletti Ferrara, Giovanni Angelo; Rojas, Winston; Rothhammer, Francisco; Navarro, Nicolas; Wang, Sijia; Adhikari, Kaustubh; Ruiz-Linares, Andrés (Nature Research, 2023)

We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant ...
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Lewczuk, Piotr; Riederer, Peter; O'Bryant, Sid E.; Verbeek, Marcel M.; Dubois, Bruno; Visser, Pieter Jelle; Jellinger, Kurt A.; Engelborghs, Sebastiaan; Ramirez, Alfredo; Parnetti, Lucilla; Jack, Clifford R.; Teunissen, Charlotte E.; Hampel, Harald; Lleó, Alberto; Jessen, Frank; Glodzik, Lidia; de Leon, Mony J.; Fagan, Anne M.; Molinuevo, José Luis; Jansen, Willemijn J.; Winblad, Bengt; Shaw, Leslie M.; Andreasson, Ulf; Otto, Markus; Mollenhauer, Brit; Wiltfang, Jens; Turner, Martin R.; Zerr, Inga; Handels, Ron; Thompson, Alexander G.; Johansson, Gunilla; Ermann, Natalia; Trojanowski, John Q.; Karaca, Ilker; Wagner, Holger; Oeckl, Patrick; van Waalwijk van Doorn, Linda; Bjerke, Maria; Kapogiannis, Dimitrios; Kuiperij, H. Bea; Farotti, Lucia; Li, Yi; Gordon, Brian A.; Epelbaum, Stéphane; Vos, Stephanie J. B.; Klijn, Catharina J. M.; Van Nostrand, William E.; Minguillon, Carolina; Schmitz, Matthias; Gallo López-Aliaga, Carla Maria; Lopez Mato, Andrea; Thibaut, Florence; Lista, Simone; Alcolea, Daniel; Zetterberg, Henrik; Blennow, Kaj; Kornhuber, Johannes; WFSBP Task Force (Taylor and Francis, 2018)

In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity ...
Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium

de Erausquin, Gabriel A.; Snyder, Heather; Brugha, Traolach S.; Seshadri, Sudha; Carrillo, Maria; Sagar, Rajesh; Huang, Yueqin; Newton, Charles; Tartaglia, Carmela; Teunissen, Charlotte; Hakanson, Krister; Akinyemi, Rufus; Prasad, Kameshwar; D'Avossa, Giovanni; Gonzalez-Aleman, Gabriela; Hosseini, Akram; Vavougios, George D.; Sachdev, Perminder; Bankart, John; Mors, Niels Peter Ole; Lipton, Richard; Katz, Mindy; Fox, Peter T.; Katshu, Mohammad Zia; Iyengar, M. Sriram; Weinstein, Galit; Sohrabi, Hamid R.; Jenkins, Rachel; Stein, Dan J.; Hugon, Jacques; Mavreas, Venetsanos; Blangero, John; Cruchaga, Carlos; Krishna, Murali; Wadoo, Ovais; Becerra, Rodrigo; Zwir, Igor; Longstreth, William T.; Kroenenberg, Golo; Edison, Paul; Mukaetova-Ladinska, Elizabeta; Staufenberg, Ekkehart; Figueredo-Aguiar, Mariana; Yecora, Agustin; Vaca, Fabiana; Zamponi, Hernan P.; Lo Re, Vincenzina; Majid, Abdul; Sundarakumar, Jonas; Gonzalez, Hector M.; Geerlings, Mirjam, I; Skoog, Ingmar; Salmoiraghi, Alberto; Boneschi, Filippo Martinelli; Patel, Vibuthi N.; Santos, Juan M.; Rivera Arroyo, Guillermo; Caballero Moreno, Antonio; Felix, Pascal; Gallo López-Aliaga, Carla Maria; Arai, Hidenori; Yamada, Masahito; Iwatsubo, Takeshi; Sharma, Malveeka; Chakraborty, Nandini; Ferreccio, Catterina; Akena, Dickens; Brayne, Carol; Maestre, Gladys; Blangero, Sarah Williams; Brusco, Luis, I; Siddarth, Prabha; Hughes, Timothy M.; Zuniga, Alfredo Ramirez; Kambeitz, Joseph; Laza, Agustin Ruiz; Allen, Norrina; Panos, Stella; Merrill, David; Ibanez, Agustin; Tsuang, Debby; Valishvili, Nino; Shrestha, Srishti; Wang, Sophia; Padma, Vasantha; Anstey, Kaarin J.; Ravindrdanath, Vijayalakshmi; Blennow, Kaj; Mullins, Paul; Pria, Anand; Mosley, Thomas H.; Gowland, Penny; Girard, Timothy D.; Bowtell, Richard; Vahidy, Farhaan S. (Wiley, 2022)

Introduction Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. ...
Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes

Nieves-Colón, M.A.; Badillo Rivera, K.M.; Sandoval, K.; Villanueva Dávalos, V.; Enriquez Lencinas, L.E.; Mendoza-Revilla, Javier; Adhikari, K.; González-Buenfil, R.; Chen, J.W.; Zhang, E.T.; Sockell, A.; Ortiz-Tello, P.; Hurtado, Gloria Malena; Condori Salas, Ramiro; Cebrecos, Ricardo; Manzaneda Choque, J.C.; Manzaneda Choque, F.P.; Yábar Pilco, G.P.; Rawls, E.; Eng, C.; Huntsman, S.; Burchard, E.; Ruiz-Linares, A.; González-José, R.; Bedoya, G.; Rothhammer, F.; Bortolini, M.C.; Poletti, Giovanni; Gallo López-Aliaga, Carla Maria; Bustamante, C.D.; Baker, J.C.; Gignoux, C.R.; Wojcik, G.L.; Moreno-Estrada, A. (Elsevier, 2022)

Preeclampsia is a multi-organ complication of pregnancy characterized by sudden hypertension and proteinuria that is among the leading causes of preterm delivery and maternal morbidity and mortality worldwide. The heterogeneity ...
Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci

Li, Yi; Xiong, Ziyi; Zhang, Manfei; Hysi, Pirro G.; Qian, Yu; Adhikari, Kaustubh; Weng, Jun; Wu, Sijie; Du, Siyuan; Gonzalez-Jose, Rolando; Schuler-Faccini, Lavinia; Bortolini, Maria-Catira; Acuna-Alonzo, Victor; Canizales-Quinteros, Samuel; Gallo López-Aliaga, Carla Maria; Poletti Ferrara, Giovanni Angelo; Bedoya, Gabriel; Rothhammer, Francisco; Wang, Jiucun; Tan, Jingze; Yuan, Ziyu; Jin, Li; Uitterlinden, André G.; Ghanbari, Mohsen; Ikram, M. Arfan; Nijsten, Tamar; Zhu, Xiangyu; Lei, Zhen; Jia, Peilin; Ruiz-Linares, Andres; Spector, Timothy D.; Wang, Sijia; Kayser, Manfred; Liu, Fan (PLoS, 2023)

Human ear morphology, a complex anatomical structure represented by a multidimensional set of correlated and heritable phenotypes, has a poorly understood genetic architecture. In this study, we quantitatively assessed 136 ...
Comparación del puntaje de la escala de depresión CES-D aplicado en una primera evaluación basal y después de 30 meses según el uso de antihipertensivos moduladores y no moduladores del sistema renina angiotensina en participantes de la cohorte crónicas

Olivera Molina, Pierina Belen (Universidad Peruana Cayetano HerediaPE, 2023)

Introducción: La hiperactividad del sistema renina angiotensina (RAS) en el cerebro está asociada con el desarrollo de depresión. En consecuencia, se sugiere que los fármacos antihipertensivos que actúan inhibiendo RAS ...
Demographic history and selection at HLA loci in Native Americans

Single, R.M.; Meyer, D.; Nunes, K.; Francisco, R.S.; Hünemeier, T.; Maiers, M.; Hurley, C.K.; Bedoya, G.; Gallo López-Aliaga, Carla Maria; Hurtado, A.M.; Llop, E.; Petzl-Erler, M.L.; Poletti, G.; Rothhammer, F.; Tsuneto, L.; Klitz, W.; Ruiz-Linares, A. (Public Library of Science, 2020)

The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this ...
Dental size variation in admixed Latin Americans: Effects of age, sex and genomic ancestry

Yang, Guangrui; Chen, Yingjie; Li, Qing; Benítez, Daniel; Ramírez, Luis Miguel; Fuentes-Guajardo, Macarena; Hanihara, Tsunehiko; Scott, G. Richard; Acuña Alonzo, Victor; Gonzalez Jose, Rolando; Bortolini, Maria Catira; Gallo López-Aliaga, Carla Maria; Poletti Ferrara, Giovanni Angelo; Rothhammer, Francisco; Rojas, Winston; Zanolli, Clément; Adhikari, Kaustubh; Ruiz-Linares, Andres; Delgado, Miguel (PLoS, 2023)

Dental size variation in modern humans has been assessed from regional to worldwide scales, especially under microevolutionary and forensic contexts. Despite this, populations of mixed continental ancestry such as contemporary ...
Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Quinto-Sánchez, Mirsha; Muñoz-Muñoz, Francesc; Gomez-Valdes, Jorge; Cintas, Celia; Navarro, Pablo; Cerqueira, Caio Cesar Silva de; Paschetta, Carolina; de Azevedo, Soledad; Ramallo, Virginia; Acuña-Alonzo, Victor; Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Hünemeier, Tábita; Everardo, Paola; de Avila, Francisco; Jaramillo, Claudia; Arias, Williams; Gallo López-Aliaga, Carla Maria; Poletti, Giovani; Bedoya, Gabriel; Bortolini, Maria Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Rosique, Javier; Ruiz-Linares, Andres; Gonzalez-Jose, Rolando (Springer Nature, 2018)

Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a ...
Disentangling Signatures of Selection Before and After European Colonization in Latin Americans

Mendoza-Revilla, J.; Chacón-Duque, J.C.; Fuentes-Guajardo, M.; Ormond, L.; Wang, K.; Hurtado, M.; Villegas, V.; Granja, V.; Acuña-Alonzo, V.; Jaramillo, C.; Arias, W.; Barquera, R.; Gómez-Valdés, J.; Villamil-Ramírez, H.; Silva de Cerqueira, C.C.; Badillo Rivera, K.M.; Nieves-Colón, M.A.; Gignoux, C.R.; Wojcik, G.L.; Moreno-Estrada, A.; Hünemeier, T.; Ramallo, V.; Schuler-Faccini, L.; Gonzalez-José, R.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo López-Aliaga, Carla Maria; Poletti, G.; Bedoya, G.; Rothhammer, F.; Balding, D.; Fumagalli, M.; Adhikari, K.; Ruiz-Linares, A.; Hellenthal, G. (Oxford University Press, 2022)

Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can ...
Facial asymmetry and genetic ancestry in Latin American admixed populations

Quinto-Sánchez, Mirsha; Adhikari, K.; Acuña-Alonzo, V.; Cintas, C.; Silva De Cerqueira, C.C.; Ramallo, V.; Castillo, L.; Farrera, A.; Jaramillo, C.; Arias, W.; Fuentes, M.; Everardo, P.; De Avila, F.; Gomez-Valdés, J.; Hünemeier, T.; Gibbon, S.; Gallo López-Aliaga, Carla Maria; Poletti, Giovanni; Rosique, J.; Bortolini, M.C.; Canizales-Quinteros, S.; Rothhammer, F.; Bedoya, G.; Ruiz-Linares, A.; González-José, R. (Wiley, 2015)

Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of ...
Factores predictores de uso problemático de alcohol en personas atendidas en una sala de emergencia

Fiestas, F.; Ponce, J.; Gallo López-Aliaga, Carla Maria; Bustamante Chavez, Ines Veronica; Ordóñez, C.; Mazzotti, G. (Instituto Nacional de Salud, 2011)

Objectives. To assess the predictive effect of key individual-level characteristics to identify cases of alcohol use problems among patients visiting an emergency room. Materials and methods. The study sample was composed ...
Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers

Zollner, Linda; Boekstegers, Felix; Barahona Ponce, Carol; Scherer, Dominique; Marcelain, Katherine; Gárate-Calderón, Valentina; Waldenberger, Melanie; Morales, Erik; Rojas, Armando; Munoz, César; Retamales, Javier; De Toro, Gonzalo; Kortmann, Allan Vera; Barajas, Olga; Rivera, María Teresa; Cortés, Analía; Loader, Denisse; Saavedra, Javiera; Gutiérrez, Lorena; Ortega, Alejandro; Bertrán, Maria Enriqueta; Bartolotti, Leonardo; Gabler, Fernando; Campos, Mónica; Alvarado, Juan; Moisán, Fabricio; Spencer, Loreto; Nervi, Bruno; Carvajal, Daniel; Losada, Héctor; Almau, Mauricio; Fernández, Plinio; Olloquequi, Jordi; Carter, Alice R.; Miquel Poblete, Juan Francisco; Bustos, Bernabe Ignacio; Fuentes Guajardo, Macarena; Gonzalez-Jose, Rolando; Bortolini, Maria Cátira; Acuña-Alonzo, Victor; Gallo López-Aliaga, Carla Maria; Ruiz Linares, Andres; Rothhammer, Francisco; Lorenzo Bermejo, Justo (MDPI, 2023)

A strong association between the proportion of indigenous South American Mapuche ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC ...
Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; Gárate-Calderón, Valentina; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, Maria Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; Fischer, Christine; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Bonet, Catalina; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; Gonzalez-Jose, Rolando; Bedoya, Gabriel; Bortolini, Maria C.; Canizales-Quinteros, Samuel; Gallo López-Aliaga, Carla Maria; Ruiz-Linares, Andres; Rothhammer, Francisco; Lorenzo Bermejo, Justo (Wiley, 2021)

BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the ...
Genetic components of human pain sensitivity: A protocol for a genome-wide association study of experimental pain in healthy volunteers

Schmid, Annina B.; Adhikari, Kaustubh; Ramirez-Aristeguieta, Luis Miguel; Chacon-Duque, Juan-Camilo; Poletti, Giovanni; Gallo López-Aliaga, Carla Maria; Rothhammer, Francisco; Bedoya, Gabriel; Ruiz-Linares, Andres; Bennett, David L. (BMJ Publishing Group, 2019)

INTRODUCTION: Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on ...
Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease

Macias-Kauffer, Luis R.; Villamil-Ramírez, Hugo; León-Mimila, Paola; Jacobo-Albavera, Leonor; Posadas-Romero, Carlos; Posadas-Sánchez, Rosalinda; López-Contreras, Blanca E.; Morán-Ramos, Sofía; Romero-Hidalgo, Sandra; Acuña-Alonzo, Víctor; Del-Río-Navarro, Blanca E.; Bortolini, Maria-Cátira; Gallo López-Aliaga, Carla Maria; Bedoya, Gabriel; Rothhammer, Francisco; González-Jose, Rolando; Ruiz-Linares, Andrés; Stephens, Christopher R.; Velazquez-Cruz, Rafael; Fernández Del Valle-Laisequilla, Cecilia; Reyes-García, Juan G.; Barranco Garduño, Lina M.; Carrasco-Portugal, Miriam Del C.; Flores-Murrieta, Francisco J.; Vargas-Alarcón, Gilberto; Aguilar-Salinas, Carlos A.; Villarreal-Molina, Teresa; Canizales-Quinteros, Samuel (Elsevier, 2018)

BACKGROUND: Serum uric acid (SUA) is a heritable trait associated with cardiovascular risk factors and coronary artery disease (CAD). Genome wide association studies (GWAS) have identified several genes associated with ...