Listar por autor "Gasho, Christopher"

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  • The 2018 Global Research Expedition on Altitude Related Chronic Health (Global REACH) to Cerro de Pasco, Peru: an Experimental Overview 
    Tymko, Michael M.; Hoiland, Ryan L.; Tremblay, Joshua C.; Stembridge, Mike; Dawkins, Tony G.; Coombs, Geoff B.; Patrician, Alexander; Howe, Connor A.; Gibbons, Travis D.; Moore, Jonathan P.; Simpson, Lydia L.; Steinback, Craig D.; Meah, Victoria L.; Stacey, Benjamin S.; Bailey, Damian M.; MacLeod, David B.; Gasho, Christopher; Anholm, James D.; Bain, Anthony R.; Lawley, Justin S.; Villafuerte, Francisco C.; Vizcardo-Galindo, Gustavo; Ainslie, Philip N. (Wiley, 2020)
    NEW FINDINGS: What is the central question of this study? Herein, a methodological overview of our research team's (Global REACH) latest high altitude research expedition to Peru is provided. What is the main finding and ...
  • Global REACH 2018: Andean highlanders, chronic mountain sickness and the integrative regulation of resting blood pressure 
    Simpson, Lydia L.; Meah, Victoria L.; Steele, Andrew R.; Gasho, Christopher; Howe, Connor A.; Dawkins, Tony G.; Busch, Stephen A.; Oliver, Samuel J.; Moralez, Gilberto; Lawley, Justin S.; Tymko, Michael M.; Vizcardo-Galindo, Gustavo A.; Figueroa-Mujíca, Rómulo J.; Villafuerte, Francisco C.; Ainslie, Phillip N.; Stembridge, Mike; Steinback, Craig D.; Moore, Jonathan P. (Wiley, 2020)
    NEW FINDINGS: What is the central question of this study? Does chronic mountain sickness (CMS) alter sympathetic neural control and arterial baroreflex regulation of blood pressure in Andean (Quechua) highlanders? What ...
  • Global Reach 2018: sympathetic neural and hemodynamic responses to submaximal exercise in Andeans with and without chronic mountain sickness 
    Hansen, Alexander B.; Amin, Sachin B.; Hofstätter, Florian; Mugele, Hendrik; Simpson, Lydia L.; Gasho, Christopher; Dawkins, Tony G.; Tymko, Michael M.; Ainslie, Philip N.; Villafuerte, Francisco C.; Hearon, Christopher M., Jr; Lawley, Justin S.; Moralez, Gilbert (American Physiological Society, 2022)
    Andeans with chronic mountain sickness (CMS) and polycythemia have similar maximal oxygen uptakes to healthy Andeans. Therefore, this study aimed to explore potential adaptations in convective oxygen transport, with a ...
  • Global REACH 2018: the adaptive phenotype to life with chronic mountain sickness and polycythaemia 
    Hansen, Alexander B.; Moralez, Gilbert; Amin, Sachin B.; Simspon, Lydia L.; Hofstaetter, Florian; Anholm, James D.; Gasho, Christopher; Stembridge, Mike; Dawkins, Tony G.; Tymko, Michael M.; Ainslie, Philip N.; Villafuerte, Francisco C.; Romero, Steve A.; Hearon Jr., Christopher M.; Lawley, Justin S. (Wiley, 2021)
    Key points: Humans suffering from polycythaemia undergo multiple circulatory adaptations including changes in blood rheology and structural and functional vascular adaptations to maintain normal blood pressure and vascular ...
  • Global REACH 2018: Volume regulation in high-altitude Andeans with and without chronic mountain sickness 
    Steele, Andrew R.; Tymko, Michael M.; Meah, Victoria L.; Simpson, Lydia L.; Gasho, Christopher; Dawkins, Tony G.; Williams, Alexandra Mackenzie; Villafuerte, Francisco C.; Vizcardo-Galindo, Gustavo A.; Figueroa-Mujíca, Rómulo J.; Ainslie, Philip N.; Stembridge, Mike; Moore, Jonathan P.; Steinback, Craig D. (American Physiological Society, 2021)
    The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is characterized by polycythemia and is associated with proteinuria despite unaltered glomerular filtration rate. However, it remains unclear ...
  • Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders. 
    Patrician, Alexander; Dawkins, Tony; Coombs, Geoff B.; Stacey, Benjamin; Gasho, Christopher; Gibbons, Travis; Howe, Connor A.; Tremblay, Joshua C.; Stone, Rachel; Tymko, Kaitlyn; Tymko, Courtney; Akins, John D.; Hoiland, Ryan L.; Vizcardo-Galindo, Gustavo A.; Figueroa-Mujíca, Rómulo; Villafuerte, Francisco C.; Bailey, Damian M.; Stembridge, Michael; Anholm, James D.; Tymko, Michael M.; Ainslie, Philip N. (Elsevier, 2021)
    BACKGROUND: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andeans with chronic mountain sickness ...
  • Lifelong exposure to high-altitude hypoxia in humans is associated with improved redox homeostasis and structural-functional adaptations of the neurovascular unit. 
    Stacey, Benjamin S.; Hoiland, Ryan L.; Caldwell, Hannah G.; Howe, Connor A.; Vermeulen, Tyler; Tymko, Michael M.; Vizcardo Galindo, Gustavo Andrés; Bermudez Pumasunco, Daniella Inés; Figueroa Mujiica, Romulo Joseph; Gasho, Christopher; Tuaillon, Edouard; Hirtz, Christophe; Lehmann, Sylvain; Marchi, Nicola; Tsukamoto, Hayato; Villafuerte Castrillón, Francisco Carlos; Ainslie, Philip N.; Bailey, Damian M. (Wiley, 2023)
    KEY POINTS: High-altitude (HA) hypoxia has the potential to alter the structural-functional integrity of the neurovascular unit (NVU) in humans. For the first time, we examined to what extent chronic and lifelong hypoxia ...
  • The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives 
    Stembridge, Mike; Williams, Alexandra M.; Gasho, Christopher; Dawkins, Tony G.; Drane, Aimee; Villafuerte, Francisco C.; Levine, Benjamin D.; Shave, Rob; Ainslie, Philip N. (National Academy of Sciences, 2019)
    In contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed ...

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