Listar por autor "Meyer, Diogo"

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  • Biased pathogenic assertions of loss of function variants challenge molecular diagnosis of admixed individuals 
    Naslavsky, Michel S.; Scliar, Marília O.; Nunes, Kelly; Wang, Jaqueline Y. T.; Yamamoto, Guilherme L.; Guio, Heinner; Tarazona-Santos, Eduardo; Duarte, Yeda A. O.; Passos-Bueno, Maria Rita; Meyer, Diogo; Zatz, Mayana (Wiley, 2021)
    Diagnosis of individuals affected by monogenic disorders was significantly improved by next-generation sequencing targeting clinically relevant genes. Whole exomes yield a large number of variants that require several ...
  • How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans 
    Nunes, Kelly; Maia, Maria Helena Thomaz; Dos Santos, Eduardo José Melo; Dos Santos, Sidney Emanuel Batista; Guerreiro, João Farias; Petzl-Erler, Maria Luiza; Bedoya, Gabriel; Gallo López-Aliaga, Carla Maria; Poletti, Giovanni; Llop, Elena; Tsuneto, Luiza; Bortolini, Maria Cátira; Rothhammer, Francisco; Single, Richard; Ruiz-Linares, Andrés; Rocha, Jorge; Meyer, Diogo (Elsevier, 2021)
    The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we ...
  • Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil 
    Naslavsky, Michel S; Scliar, Marilia O; Yamamoto, Guilherme L; Wang, Jaqueline Yu Ting; Zverinova, Stepanka; Karp, Tatiana; Nunes, Kelly; Ceroni, Jose Ricardo Magliocco; de Carvalho, Diego Lima; da Silva Simoes, Carlos Eduardo; Bozoklian, Daniel; Nonaka, Ricardo; Dos Santos Brito Silva, Nayane; da Silva Souza, Andreia; de Souza Andrade, Heloisa; Passos, Marilia Rodrigues Silva; Castro, Camila Ferreira Bannwart; Mendes-Junior, Celso T; Mercuri, Rafael L V; Miller, Thiago L A; Buzzo, Jose Leonel; Rego, Fernanda O; Araujo, Nathalia M; Magalhaes, Wagner C S; Mingroni-Netto, Regina Celia; Borda, Victor; Guio, Heinner; Rojas, Carlos P; Sanchez, Cesar; Caceres, Omar; Dean, Michael; Barreto, Mauricio L; Lima-Costa, Maria Fernanda; Horta, Bernardo L; Tarazona-Santos, Eduardo; Meyer, Diogo; Galante, Pedro A F; Guryev, Victor; Castelli, Erick C; Duarte, Yeda A O; Passos-Bueno, Maria Rita; Zatz, Mayana (Springer Nature, 2022)
    As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage ...

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