Universidad Peruana Cayetano Heredia

Listar por autor "Tarazona-Santos, Eduardo"

Listar por autor "Tarazona-Santos, Eduardo"

Ordenar por:Orden:Resultados:

  • Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes 
    Scliar, Marilia O.; Sant'Anna, Hanaisa P.; Santolalla Robles, Meddly Leslye; Leal, Thiago P.; Araujo, Nathalia M.; Alvim, Isabela; Borda, Victor; Magalhaes, Wagner C. S.; Gouveia, Mateus H.; Lyra, Ricardo; Machado, Moara; Michelin, Lucas; Rodrigues, Maira R.; Araujo, Gilderlanio S.; Kehdy, Fernanda S. G.; Zolini, Camila; Peixoto, Sergio V.; Luizon, Marcelo R.; Lobo, Francisco; Naslavsky, Michel S.; Yamamoto, Guilherme L.; Duarte, Yeda A. O.; Hansen, Matthew E. B.; Norris, Shane A.; Gilman, Robert Hugh; Guio, Heinner; Hsing, Ann W.; Mbulaiteye, Sam M.; Mensah, James; Dutil, Julie; Yeager, Meredith; Yeboah, Edward; Tishkoff, Sarah A.; Choudhury, Ananyo; Ramsay, Michele; Passos-Bueno, Maria Rita; Zatz, Mayana; O'Connor, Timothy D.; Pereira, Alexandre C.; Barreto, Mauricio L.; Lima-Costa, Maria Fernanda; Horta, Bernardo L.; Tarazona-Santos, Eduardo (Springer, 2021)
    Background/objectives: Admixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely underrepresented in genomic ...
  • Bayesian inferences suggest that Amazon Yunga Natives diverged from Andeans less than 5000 ybp: Implications for South American prehistory 
    Scliar, Marilia O.; Gouveia, Mateus H.; Benazzo, Andrea; Ghirotto, Silvia; Fagundes, Nelson J.; Leal, Thiago P.; Magalhães, Wagner C.; Pereira, Latife; Rodrigues, Maira R.; Soares-Souza, Giordano B.; Cabrera, Lilia; Berg, Douglas E.; Gilman, Robert Hugh; Bertorelle, Giorgio; Tarazona-Santos, Eduardo (BioMed Central, 2014)
    Background: Archaeology reports millenary cultural contacts between Peruvian Coast-Andes and the Amazon Yunga, a rainforest transitional region between Andes and Lower Amazonia. To clarify the relationships between cultural ...
  • Biased pathogenic assertions of loss of function variants challenge molecular diagnosis of admixed individuals 
    Naslavsky, Michel S.; Scliar, Marília O.; Nunes, Kelly; Wang, Jaqueline Y. T.; Yamamoto, Guilherme L.; Guio, Heinner; Tarazona-Santos, Eduardo; Duarte, Yeda A. O.; Passos-Bueno, Maria Rita; Meyer, Diogo; Zatz, Mayana (Wiley, 2021)
    Diagnosis of individuals affected by monogenic disorders was significantly improved by next-generation sequencing targeting clinically relevant genes. Whole exomes yield a large number of variants that require several ...
  • Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease 
    Young, William J.; Haessler, Jeffrey; Benjamins, Jan-Walter; Repetto, Linda; Yao, Jie; Isaacs, Aaron; Harper, Andrew R.; Ramirez, Julia; Garnier, Sophie; van Duijvenboden, Stefan; Baldassari, Antoine R.; Concas, Maria Pina; Duong, ThuyVy; Foco, Luisa; Isaksen, Jonas L.; Mei, Hao; Noordam, Raymond; Nursyifa, Casia; Richmond, Anne; Santolalla Robles, Meddly Leslye; Sitlani, Colleen M.; Soroush, Negin; Thériault, Sébastien; Trompet, Stella; Aeschbacher, Stefanie; Ahmadizar, Fariba; Alonso, Alvaro; Brody, Jennifer A.; Campbell, Archie; Correa, Adolfo; Darbar, Dawood; De Luca, Antonio; Deleuze, Jean-François; Ellervik, Christina; Fuchsberger, Christian; Goel, Anuj; Grace, Christopher; Guo, Xiuqing; Hansen, Torben; Heckbert, Susan R.; Jackson, Rebecca D.; Kors, Jan A.; Lima-Costa, Maria Fernanda; Linneberg, Allan; Macfarlane, Peter W.; Morrison, Alanna C.; Navarro, Pau; Porteous, David J.; Pramstaller, Peter P.; Reiner, Alexander P.; Risch, Lorenz; Schotten, Ulrich; Shen, Xia; Sinagra, Gianfranco; Soliman, Elsayed Z.; Stoll, Monika; Tarazona-Santos, Eduardo; Tinker, Andrew; Trajanoska, Katerina; Villard, Eric; Warren, Helen R.; Whitsel, Eric A.; Wiggins, Kerri L.; Arking, Dan E.; Avery, Christy L.; Conen, David; Girotto, Giorgia; Grarup, Niels; Hayward, Caroline; Jukema, J.Wouter; Mook-Kanamori, Dennis O.; Olesen, Morten Salling; Padmanabhan, Sandosh; Psaty, Bruce M.; Pattaro, Cristian; Ribeiro, Antonio Luiz P.; Rotter, Jerome I.; Stricker, Bruno H.; van der Harst, Pim; van Duijn, Cornelia M.; Verweij, Niek; Wilson, James G.; Orini, Michele; Charron, Philippe; Watkins, Hugh; Kooperberg, Charles; Lin, Henry J.; Wilson, James F.; Kanters, Jørgen K.; Sotoodehnia, Nona; Mifsud, Borbala; Lambiase, Pier D.; Tereshchenko, Larisa G.; Munroe, Patricia B. (Nature Research, 2023)
    The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry ...
  • Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans 
    Rodrigues-Soares, Fernanda; Penas-Lledo, Eva M.; Tarazona-Santos, Eduardo; Sosa-Macias, Martha; Teran, Enrique; Lopez-Lopez, Marisol; Rodeiro, Idania; Moya, Graciela E.; Calzadilla, Luis R.; Ramirez-Roa, Ronald; Grazina, Manuela; Estevez-Carrizo, Francisco E.; Barrantes, Ramiro; Llerena, Adrian (Wiley, 2019)
    We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ...
  • GSTT1/GSTM1 Genotype and Anti-Tuberculosis Drug-Induced Hepatotoxicity in Peruvian Patients 
    Jaramillo-Valverde, Luis; Levano, Kelly S.; Tarazona, David D.; Vasquez-Dominguez, Andres; Toledo-Nauto, Anel; Capristano, Silvia; Sanchez, Cesar; Tarazona-Santos, Eduardo; Ugarte Gil, Cesar Augusto; Guio, Heinner (MDPI, 2022)
    In Peru, 24,581 people were diagnosed with tuberculosis (TB) in 2020. Although TB treatments are effective, 3.4–13% are associated with significant adverse drug reactions (ADRs), with drug-induced liver injury (DILI) ...
  • Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans 
    Kehdy, Fernanda S. G.; Pita-Oliveira, Murilo; Scudeler, Mariana M.; Torres-Loureiro, Sabrina; Zolini, Camila; Moreira, Rennan; Michelin, Lucas A.; Alvim, Isabela; Silva-Carvalho, Carolina; Furlan, Vinicius C.; Aquino, Marla M.; Santolalla Robles, Meddly Leslye; Borda, Victor; Soares-Souza, Giordano B.; Jaramillo-Valverde, Luis; Vasquez-Dominguez, Andres; Neira, Cesar Sanchez; Aguiar, Renato S.; Verdugo, Ricardo A.; O Connor, Timothy D.; Guio, Heinner; Tarazona-Santos, Eduardo; Leal, Thiago P.; Rodrigues-Soares, Fernanda (Brazilian Society of Genetics, 2021)
    For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates ...
  • NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruvian patients 
    Jaramillo-Valverde, Luis; Levano, Kelly S.; Tarazona, David D.; Capristano, Silvia; Zegarra-Chaponan, Roberto; Sanchez, Cesar; Yufra-Picardo, Velia M.; Tarazona-Santos, Eduardo; Ugarte Gil, Cesar Augusto; Guio, Heinner (Wiley, 2022)
    Background: In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019. Although TB treatment is effective, 3.4%–13% is associated with significant adverse drug reactions (ADR), considering drug-induced liver ...
  • Origins, admixture dynamics and homogenization of the African gene pool in the Americas 
    Gouveia, Mateus H.; Borda, Victor; Leal, Thiago P.; Moreira, Rennan G.; Bergen, Andrew W.; Kehdy, Fernanda S. G.; Alvim, Isabela; Aquino, Marla M.; Araujo, Gilderlanio S.; Araujo, Nathalia M.; Furlan, Vinicius; Liboredo, Raquel; Machado, Moara; Magalhaes, Wagner C. S.; Michelin, Lucas A.; Rodrigues, Maíra R.; Rodrigues-Soares, Fernanda; Sant Anna, Hanaisa P.; Santolalla Robles, Meddly Leslye; Scliar, Marília O.; Soares-Souza, Giordano; Zamudio, Roxana; Zolini, Camila; Bortolini, Maria Catira; Dean, Michael; Gilman, Robert Hugh; Guio, Heinner; Rocha, Jorge; Pereira, Alexandre C.; Barreto, Mauricio L.; Horta, Bernardo L.; Lima-Costa, Maria F.; Mbulaiteye, Sam M.; Chanock, Stephen J.; Tishkoff, Sarah A.; Yeager, Meredith; Tarazona-Santos, Eduardo (Oxford University Press, 2020)
    The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to ...
  • Pharmacogenetics research in Brazil: a systematic review. 
    Torres-Loureiro, Sabrina; Scudeler, Mariana M.; Andrade, Poliana Xc; Sampaio-Coelho, Julia; Nobre, Igor H.; Céspedes-Garro, Carolina; Tarazona-Santos, Eduardo; Llerena, Adrián; Rodrigues-Soares, Fernanda (Future Medicine, 2022)
    Aim: Pharmacogenomics (PGx) is a rising scientific area in many countries, such as Brazil. Objectives: To identify biomarkers, therapeutic areas, probe drugs and regions/ethnicities most studied in the country in order ...
  • Population genetics of PDE4B (Phosphodiesterase-4B) in neglected native americans: implications for cancer pharmacogenetics. 
    Moreira, Rennan Garcias; Saraiva-Duarte, Julia Maria; Pereira, Alexandre Costa; Sosa-Macias, Martha; Galaviz-Hernandez, Carlos; Santolalla Robles, Meddly Leslye; Magalhaes, Wagner C. S.; Zolini, Camila; Leal, Thiago Peixoto; Balazs, Zsolt; Llerena, Adrian; Gilman, Robert Hugh; Mill, Jose Geraldo; Borda, Victor; Guio, Heinner; O'Connor, Timothy D.; Tarazona-Santos, Eduardo; Rodrigues-Soares, Fernanda (Wiley, 2022)
    PDE4B (phosphodiesterase-4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic ...
  • Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry 
    Zamudio, Roxana; Pereira, Latife; Rocha, Carolina D.; Berg, Douglas E.; Muniz-Queiroz, Thais; Sant Anna, Hanaisa P.; Cabrera, Lilia; Combe, Juan M.; Herrera, Phabiola; Jahuira, Martha H.; Leao, Felipe B.; Lyon, Fernanda; Prado, William A.; Rodrigues, Maira R.; Rodrigues-Soares, Fernanda; Santolalla Robles, Meddly Leslye; Zolini, Camila; Silva, Aristobolo M.; Gilman, Robert Hugh; Tarazona-Santos, Eduardo; Kehdy, Fernanda S. G. (Springer, 2015)
    Background. Gastric adenocarcinoma is associated with chronic infection by Helicobacter pylori and with the host inflammatory response triggered by it, with substantial inter-person variation in the immune response profile ...
  • Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil 
    Naslavsky, Michel S; Scliar, Marilia O; Yamamoto, Guilherme L; Wang, Jaqueline Yu Ting; Zverinova, Stepanka; Karp, Tatiana; Nunes, Kelly; Ceroni, Jose Ricardo Magliocco; de Carvalho, Diego Lima; da Silva Simoes, Carlos Eduardo; Bozoklian, Daniel; Nonaka, Ricardo; Dos Santos Brito Silva, Nayane; da Silva Souza, Andreia; de Souza Andrade, Heloisa; Passos, Marilia Rodrigues Silva; Castro, Camila Ferreira Bannwart; Mendes-Junior, Celso T; Mercuri, Rafael L V; Miller, Thiago L A; Buzzo, Jose Leonel; Rego, Fernanda O; Araujo, Nathalia M; Magalhaes, Wagner C S; Mingroni-Netto, Regina Celia; Borda, Victor; Guio, Heinner; Rojas, Carlos P; Sanchez, Cesar; Caceres, Omar; Dean, Michael; Barreto, Mauricio L; Lima-Costa, Maria Fernanda; Horta, Bernardo L; Tarazona-Santos, Eduardo; Meyer, Diogo; Galante, Pedro A F; Guryev, Victor; Castelli, Erick C; Duarte, Yeda A O; Passos-Bueno, Maria Rita; Zatz, Mayana (Springer Nature, 2022)
    As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage ...

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