Listar por tema "AAA+ ATPase"

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Knots can impair protein degradation by ATP-dependent proteases

San Martín, Álvaro; Rodriguez-Aliaga, Piere; Molina, José Alejandro; Martin, Andreas; Bustamante, Carlos; Baez, Mauricio (National Academy of Sciences, 2017)

ATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized ...