Listar por tema "Chloroquine"

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  • Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships 
    Mendoza, A.; Pérez-Silanes, S.; Quiliano, M.; Pabón, A.; Galiano, S.; González, G.; Garavito, G.; Zimic-Peralta, Mirko Juan; Vaisberg Wollach, Abraham Jaime; Aldana, I.; Monge, A.; Deharo, E. (Elsevier, 2011)
    Piperazine and pyrrolidine derivatives were synthesised and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture. The combined presence of a hydroxyl ...
  • New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities 
    Barea, C.; Pabón, A.; Castillo Pareja, Denis Helan; Zimic-Peralta, Mirko Juan; Quiliano, M.; Galiano, S.; Pérez-Silanes, S.; Monge, A.; Deharo, E.; Aldana, I. (Elsevier, 2011)
    Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2- carbonitrile derivatives were synthesized and evaluated for their in vitro ...
  • Population structure and spatio-temporal transmission dynamics of Plasmodium vivax after radical cure treatment in a rural village of the Peruvian Amazon 
    Delgado Ratto, Christopher; Soto-Calle, Veronica E.; Van Den Eede, Peter; Gamboa Vilela, Dionicia Baziliza; Rosas, Angel; Abatih, Emmanuel N.; Rodriguez Ferrucci, Hugo; Llanos Cuentas, Elmer Alejandro; Van Geertruyden, Jean-Pierre; Erhart, Annette; D'Alessandro, Umberto (BioMed Central, 2014)
    Background: Despite the large burden of Plasmodium vivax, little is known about its transmission dynamics. This study explored the population structure and spatio-temporal dynamics of P. vivax recurrent infections after ...
  • Single-dose tafenoquine to prevent relapse of plasmodium vivax malaria 
    Lacerda, M.V.G.; Llanos Cuentas, Elmer Alejandro; Krudsood, S.; Lon, C.; Saunders, D.L.; Mohammed, R.; Yilma, D.; Pereira, D.B.; Espino, F.E.J.; Mia, R.Z.; Chuquiyauri, R.; Val, F.; Casapía, M.; Monteiro, W.M.; Brito, M.A.M.; Costa, M.R.F.; Buathong, N.; Noedl, H.; Diro, E.; Getie, S.; Wubie, K.M.; Abdissa, A.; Zeynudin, A.; Abebe, C.; Tada, M.S.; Brand, F.; Beck, H.-P.; Angus, B.; Duparc, S.; Kleim, J.-P.; Kellam, L.M.; Rousell, V.M.; Jones, S.W.; Hardaker, E.; Mohamed, K.; Clover, D.D.; Fletcher, K.; Breton, J.J.; Ugwuegbulam, C.O.; Green, J.A.; Koh, G.C.K.W. (Massachusetts Medical Society, 2019)
    BACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical cure"). Tafenoquine ...
  • Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents 
    Camacho, J.; Barazarte, A.; Gamboa, N.; Rodrigues, J.; Rojas, R.; Vaisberg Wollach, Abraham Jaime; Gilman, Robert Hugh; Charris, J. (Elsevier, 2011)
    A series of N′-substituted-2-(5-nitrofuran or 5-nitrothiophen-2-yl)- 3H-benzo[d]imidazole-5-carbohydrazide derivatives were synthesized and investigated for their abilities to inhibit β-hematin formation, hemoglobin ...
  • Tafenoquine versus primaquine to prevent relapse of plasmodium vivax malaria 
    Llanos Cuentas, Elmer Alejandro; Lacerda, M.V.G.; Hien, T.T.; Vélez, I.D.; Namaik-Larp, C.; Chu, C.S.; Villegas, M.F.; Val, F.; Monteiro, W.M.; Brito, M.A.M.; Costa, M.R.F.; Chuquiyauri, R.; Casapía, M.; Nguyen, C.H.; Aruachan, S.; Papwijitsil, R.; Nosten, F.H.; Bancone, G.; Angus, B.; Duparc, S.; Craig, G.; Rousell, V.M.; Jones, S.W.; Hardaker, E.; Clover, D.D.; Kendall, L.; Mohamed, K.; Koh, G.C.K.W.; Wilches, V.M.; Breton, J.J.; Green, J.A. (Massachusetts Medical Society, 2019)
    BACKGROUND: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed "radical cure." METHODS: We ...

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