Listar por tema "Compensatory mutations"

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Determination of potentially novel compensatory mutations in rpoC associated with rifampin resistance and rpoB mutations in Mycobacterium tuberculosis Clinical isolates from Peru

Vargas Ruiz, Ana Paula; Rios, A.; Grandjean, Louis; Kirwan, D.; Gilman, Robert Hugh; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Medknow Publications, 2020)

Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations ...