Listar por tema "Drug resistance"

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  • Antibiotic point prevalence survey and antimicrobial resistance in hospitalized patients across Peruvian reference hospitals. 
    Rondon Paz, Claudia Rossana; García Apac, Coralith Marlinda; Krapp Lopez, Fiorella del Carmen; Machaca, Isela; Olivera, Marco; Fernández, Victor; Villegas, Miguel; Vilcapoma, Pierina; Casapia, Martin; Concha-Velasco, Fátima; Díaz, Juan C.; Sarmiento, Favio; Guillermo, Rosa; Farnham, Andrea; Sutter, Sarah T.; Kuenzli, Esther (Elsevier, 2023)
    BACKGROUND: Peru reports higher levels than other countries in Latin America of resistance to antimicrobials among Gram-positive and Gram-negative bacteria, however data on antibiotic use in Peru are scarce. This study ...
  • Evaluation of the broth microdilution plate methodology for susceptibility testing of Mycobacterium tuberculosis in Peru 
    Puyen, Zully M.; Santos-Lazaro, David; Vigo, Aiko N.; Coronel, Jorge; Alarcon, Miriam J.; Cotrina, Vidia V.; Moore, David Alexander James (BioMed Central, 2022)
    Background: Tuberculosis (TB) is a communicable, preventable and curable disease caused by the bacterium Mycobacterium tuberculosis (MTB). Peru is amongst the 30 countries with the highest burden of multidrug-resistant ...
  • Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru 
    Schwalb Calderon, Alvaro; Cachay Figueroa, Rodrigo Antonio; Meza, E.; Cáceres Nakiche, Tatiana; Blackman, A.; Maruri, F.; Sterling, T.R.; Gotuzzo Herencia, José Eduardo (BioMed Central, 2021)
    Objective: To determine at two distinct time points the prevalence of resistance to ofloxacin (OFX), the representative class drug of fluoroquinolones (FQs), in M. tuberculosis isolates susceptible to first-line drugs. ...
  • The history of 20th century malaria control in Peru 
    Griffing, Sean M.; Gamboa Vilela, Dionicia Baziliza; Udhayakumar, Venkatachalam (BioMed Central, 2013)
    Malaria has been part of Peruvian life since at least the 1500s. While Peru gave the world quinine, one of the first treatments for malaria, its history is pockmarked with endemic malaria and occasional epidemics. In this ...
  • HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis 
    Loiseau, C.; Brites, D.; Reinhard, M.; Zürcher, K.; Borrell, S.; Ballif, M.; Fenner, L.; Cox, H.; Rutaihwa, L.K.; Wilkinson, R.J.; Yotebieng, M.; Jane Carter, E.; Abimiku, A.; Marcy, O.; Gotuzzo Herencia, José Eduardo; Avihingsanon, A.; Zetola, N.; Doulla, B.; Böttger, E.C.; Egger, M.; Gagneux, S. (American Society for Microbiology, 2020)
    We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant ...
  • Molecular Surveillance of Malaria Using the PF AmpliSeq Custom Assay for Plasmodium falciparum Parasites from Dried Blood Spot DNA Isolates from Peru. 
    Kattenberg, Johanna Helena; Van Dijk, Norbert J.; Fernandez Miñope, Carlos Alberto; Guetens, Pieter; Mutsaers, Mathijs; Gamboa Vilela, Dionicia Baziliza; Rosanas-Urgell, Anna (Bio-Protocol, 2023)
    Malaria molecular surveillance has great potential to support national malaria control programs (NMCPs), informing policy for its control and elimination. Here, we present a new three-day workflow for targeted resequencing ...
  • Molecular surveillance of the Plasmodium vivax multidrug resistance 1 gene in Peru between 2006 and 2015 
    Villena, F.E.; Maguiña, J.L.; Santolalla Robles, Meddly Leslye; Pozo, E.; Salas, C.J.; Ampuero, J.S.; Lescano Guevara, Andres Guillermo; Bishop, D.K.; Valdivia, H.O. (BioMed Central, 2020)
    Background: The high incidence of Plasmodium vivax infections associated with clinical severity and the emergence of chloroquine (CQ) resistance has posed a challenge to control efforts aimed at eliminating this disease. ...
  • Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients 
    Reichmuth, M.L.; Hömke, R.; Zürcher, K.; Sander, P.; Avihingsanon, A.; Collantes, J.; Loiseau, C.; Borrell, S.; Reinhard, M.; Wilkinson, R.J.; Yotebieng, M.; Fenner, L.; Böttger, E.C.; Gagneux, S.; Egger, M.; Keller, P.M.; International epidemiology Databases to Evaluate AIDS (IeDEA) (American Society for Microbiology, 2020)
    Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. ...
  • Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds 
    Rueda, Daniel; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Bueno, Carlos; Santos, Marco; Pando-Robles, Victoria; Batista, Cesar V.; Zimic-Peralta, Mirko Juan (Elsevier, 2014)
    Recombinant wild-pyrazinamidase from H37Rv Mycobacterium tuberculosis was analyzed by gel electrophoresis under differential reducing conditions to evaluate its quaternary structure. PZAse was fractionated by size exclusion ...
  • An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples 
    Ahouidi, A.; Ali, M.; Almagro-Garcia, J.; Amambua-Ngwa, A.; Amaratunga, C.; Amato, R.; Amenga-Etego, L.; Andagalu, B.; Anderson, T.J.C.; Andrianaranjaka, V.; Apinjoh, T.; Ariani, C.; Ashley, E.A.; Auburn, S.; Awandare, G.; Ba, H.; Baraka, V.; Barry, A.E.; Bejon, P.; Bertin, G.I.; Boni, M.F.; Borrmann, S.; Bousema, T.; Branch, O.; Bull, P.C.; Busby, G.B.J.; Chookajorn, T.; Chotivanich, K.; Claessens, A.; Conway, D.; Craig, A.; D'Alessandro, U.; Dama, S.; Day, N.P.J.; Denis, B.; Diakite, M.; Djimdé, A.; Dolecek, C.; Dondorp, A.M.; Drakeley, C.; Drury, E.; Duffy, P.; Echeverry, D.F.; Egwang, T.G.; Erko, B.; Fairhurst, R.M.; Faiz, A.; Fanello, C.A.; Fukuda, M.M.; Gamboa Vilela, Dionicia Baziliza; Ghansah, A.; Golassa, L.; Goncalves, S.; Hamilton, W.L.; Harrison, G.L.A.; Hart, L.; Henrichs, C.; Hien, T.T.; Hill, C.A.; Hodgson, A.; Hubbart, C.; Imwong, M.; Ishengoma, D.S.; Jackson, S.A.; Jacob, C.G.; Jeffery, B.; Jeffreys, A.E.; Johnson, K.J.; Jyothi, D.; Kamaliddin, C.; Kamau, E.; Kekre, M.; Kluczynski, K.; Kochakarn, T.; Konaté, A.; Kwiatkowski, D.P.; Kyaw, M.P.; Lim, P.; Lon, C.; Loua, K.M.; Maïga-Ascofaré, O.; Malangone, C.; Manske, M.; Marfurt, J.; Marsh, K.; Mayxay, M.; Miles, A.; Miotto, O.; Mobegi, V.; Mokuolu, O.A.; Montgomery, J.; Mueller, I.; Newton, P.N.; Nguyen, T.; Nguyen, T.-N.; Noedl, H.; Nosten, F.; Noviyanti, R.; Nzila, A.; Ochola-Oyier, L.I.; Ocholla, H.; Oduro, A.; Omedo, I.; Onyamboko, M.A.; Ouedraogo, J.-B.; Oyebola, K.; Pearson, R.D.; Peshu, N.; Phyo, A.P.; Plowe, C.V.; Price, R.N.; Pukrittayakamee, S.; Randrianarivelojosia, M.; Rayner, J.C.; Ringwald, P.; Rockett, K.A.; Rowlands, K.; Ruiz, L.; Saunders, D.; Shayo, A.; Siba, P.; Simpson, V.J.; Stalker, J.; Su, X.-Z.; Sutherland, C.; Takala-Harrison, S.; Tavul, L.; Thathy, V.; Tshefu, A.; Verra, F.; Vinetz, Joseph Michael; Wellems, T.E.; Wendler, J.; White, N.J.; Wright, I.; Yavo, W.; Ye, H.; MalariaGEN (F1000 Research, 2021)
    MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum ...
  • Parental Antibiotic Use in Urban and Peri-Urban Health Care Centers in Lima: A Cross-Sectional Study of Knowledge, Attitudes, and Practices. 
    Paredes, Jose L.; Navarro Hoyos, Rafaella Alexandra; Riveros Ramirez, Maribel Denise; Picon, Veronica; Conde, Francisco; Suito-Ferrand, Mario; Ochoa Woodell, Theresa Jean (SAGE Publications, 2019)
    In pediatric patients, the antibiotic use is affected by parental beliefs and practices; especially in countries where it is possible to acquire them without prescription. This study aims to describe the knowledge, attitudes, ...
  • Resistant Gram-negative infections in the outpatient setting in Latin America 
    Salles, M.J.C.; Zurita, J.; Mejía, C.; Villegas, M.V.; Alvarez, C.; Bavestrello, L.; Berezin, E.; Gotuzzo Herencia, José Eduardo; Guzmán-Blanco, M.; Labarca, J.A.; Luna, C.M.; Nouer, S.; Rodríguez-Noriega, E.; Seas Ramos, Carlos Rafael (Cambridge University Press, 2013)
    Latin America has a high rate of community-associated infections caused by multidrug-resistant Enterobacteriaceae relative to other world regions. A review of the literature over the last 10 years indicates that urinary ...
  • Treatment failure in leishmaniasis: Drug-resistance or another (epi-) phenotype? 
    Vanaerschot, Manu; Dumetz, Franck; Roy, Syamal; Ponte-Sucre, Alicia; Arévalo Zelada, Jorge Luis; Dujardin, Jean-Claude (Taylor and Francis, 2014)
    Two major leishmaniasis treatments have shown a significant decrease in effectiveness in the last few decades, mostly in the Indian subcontinent but also in other endemic areas. Drug resistance of Leishmania correlated ...
  • Tuberculosis y salud pública: ¿derechos individuales o derechos colectivos? 
    Llanos Zavalaga, Luis Fernando; Velásquez-Hurtado, J.E.; Garcia Funegra, Patricia Jannet; Gotuzzo Herencia, José Eduardo (Instituto Nacional de Salud, 2012)
    Tuberculosis (TB) persists as a major public health problem in our country. The appearance of resistant strains has complicated its control and questioned the appropriateness of the current measures towards prevention and ...

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