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Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships

Mendoza, A.; Pérez-Silanes, S.; Quiliano, M.; Pabón, A.; Galiano, S.; González, G.; Garavito, G.; Zimic-Peralta, Mirko Juan; Vaisberg Wollach, Abraham Jaime; Aldana, I.; Monge, A.; Deharo, E. (Elsevier, 2011)

Piperazine and pyrrolidine derivatives were synthesised and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture. The combined presence of a hydroxyl ...
New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae)

Bertani, S.; Houël, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. (Elsevier, 2012)

Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown ...

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