Listar por tema "Mutation"

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  • Antiviral Resistance and Correlates of Virologic Failure in the first Cohort of HIV-Infected Children Gaining Access to Structured Antiretroviral Therapy in Lima, Peru: A Cross-Sectional Analysis 
    Rath, Barbara A.; von Kleist, Max; Castillo, Maria E.; Kolevic, Lenka; Caballero, Patricia; Soto-Castellares, Giselle; Amedee, Angela M.; Robinson, James E.; Katzenstein, David K.; Van Dyke, Russell B.; Oberhelman, Richard A. (BioMed Central, 2013)
    Background: The impact of extended use of ART in developing countries has been enormous. A thorough understanding of all factors contributing to the success of antiretroviral therapy is required. The current study aims to ...
  • Azole resistance among clinical isolates of Aspergillus fumigatus in Lima-Peru 
    Bustamante Rufino, Ana Beatriz; Illescas, Luis Ricardo; Posadas, Andres; Campos, Pablo E. (Oxford University Press, 2019)
    Azole resistance among Aspergillus fumigatus isolates, which is mainly related to mutations in the cyp51A gene, is a concern because it is rising, worldwide disseminated, and associated with treatment failure and death. ...
  • Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru 
    Grandjean, Louis; Gilman, Robert Hugh; Iwamoto, Tomatada; Köser, Claudio U.; Coronel, Jorge; Zimic-Peralta, Mirko Juan; Török, M. Estee; Ayabina, Diepreye; Kendall, Michelle; Fraser, Christophe; Harris, Simon; Parkhill, Julian; Peacock, Sharon J.; Moore, David Alexander James; Colijn, Caroline (Public Library of Science, 2017)
    BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic ...
  • Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection 
    Dudley, Matthew Z.; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Ticona, Eduardo; Friedland, Jon S.; Kirwan, Daniela E.; Caviedes, Luz; Rodriguez, Richard; Cabrera, Lilia Z.; Coronel, Jorge; Grandjean, Louis; Moore, David Alexander James; Evans, Carlton Anthony William; Huaroto, Luz; Chavez-Perez, Victor; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2016)
    Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)–positive patients, as these patients are at heightened risk of developing ...
  • Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears 
    Rowneki, M.; Aronson, N.; Du, P.; Sachs, P.; Blakemore, R.; Chakravorty, S.; Levy, S.; Jones, A.L.; Trivedi, G.; Chebore, S.; Addo, D.; Byarugaba, D.K.; Njobvu, P.D.; Wabwire-Mangen, F.; Erima, B.; Ramos, E.S.; Evans, Carlton Anthony William; Hale, B.; Mancuso, J.D.; Alland, D. (Public Library of Science, 2020)
    Background: Drug susceptibility testing for Mycobacterium tuberculosis (MTB) is difficult to perform in resource-limited settings where Acid Fast Bacilli (AFB) smears are commonly used for disease diagnosis and monitoring. ...
  • Development and analysis of furazolidone-resistant Escherichia coli mutants 
    Martinez-Puchol, Sandra; Gomes, Claudia; Pons, Maria J.; Ruiz-Roldan, Lidia; Torrents de la Pena, Alba; Ochoa Woodell, Theresa Jean; Ruiz, Joaquim (Wiley, 2015)
    Furazolidone-resistant mutants were obtained from four clinical isolates of diarrhoeagenic Escherichia coli. The stability of the resistance and the frequency of mutation were established. The minimal inhibitory concentration ...
  • Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru 
    Quispe-Ricalde, Maria Antonieta; Castelán-Sánchez, Hugo G.; Meza-Rodríguez, Pablo M.; Dávila-Ramos, Sonia; Sierra, José Luis; Batista-Garcia, Ramón; Concha-Velasco, Fátima; Lucana, Sonia Flores; De Santa Cruz, José; Zea, Víctor; Galarza, Marco; Caceres-Rey, Omar; Tsukayama Cisneros, Pablo; Foronda, Pilar; Soto-Chambi, Brandon Jason; Abreu, Nestor (Springer, 2023)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries. However, most studies in Peru have focused on Lima, the capital city, without ...
  • Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage 
    Merker, Matthias; Blin, Camille; Mona, Stefano; Duforet-Frebourg, Nicolas; Lecher, Sophie; Willery, Eve; Blum, Michael G. B.; Rusch-Gerdes, Sabine; Mokrousov, Igor; Aleksic, Eman; Allix-Beguec, Caroline; Antierens, Annick; Augustynowicz-Kopec, Ewa; Ballif, Marie; Barletta, Francesca; Beck, Hans Peter; Barry, Clifton E. 3rd; Bonnet, Maryline; Borroni, Emanuele; Campos-Herrero, Isolina; Cirillo, Daniela; Cox, Helen; Crowe, Suzanne; Crudu, Valeriu; Diel, Roland; Drobniewski, Francis; Fauville-Dufaux, Maryse; Gagneux, Sebastien; Ghebremichael, Solomon; Hanekom, Madeleine; Hoffner, Sven; Jiao, Wei-wei; Kalon, Stobdan; Kohl, Thomas A.; Kontsevaya, Irina; Lillebaek, Troels; Maeda, Shinji; Nikolayevskyy, Vladyslav; Rasmussen, Michael; Rastogi, Nalin; Samper, Sofia; Sanchez-Padilla, Elisabeth; Savic, Branislava; Shamputa, Isdore Chola; Shen, Adong; Sng, Li-Hwei; Stakenas, Petras; Toit, Kadri; Varaine, Francis; Vukovic, Dragana; Wahl, Celine; Warren, Robin; Supply, Philip; Niemann, Stefan; Wirth, Thierry (Springer Nature, 2015)
    Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical ...
  • Immunological detection of pyrazine-2- carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis 
    Florentini, E.A.; Angulo, N.; Gilman, Robert Hugh; Alcántara, R.; Roncal, E.; Antiparra, R.; Toscano, E.; Vallejos, K.; Kirwan, D.; Zimic-Peralta, Mirko Juan; Sheen Cortavarria, Patricia (Public Library of Science, 2020)
    Pyrazinamide (PZA) susceptibility testing in Mycobacterium tuberculosis (Mtb) is a current area of development and PZA-resistant strains are increasingly prevalent. Previous studies have demonstrated that the detection of ...
  • In vitro development and analysis of escherichia coli and shigella boydii azithromycin-resistant mutants 
    Gomes, Claudia; Pons, Maria J.; Magallon-Tejada, Ariel; Durand Vara, David Percy; Lluque, Angela; Mosquito, Susan; Riveros Ramirez, Maribel Denise; Mercado, Erik; Prada, Ana; Ochoa Woodell, Theresa Jean; Ruiz, Joaquim (Mary Ann Liebert, 2013)
    Three clinical isolates of E. coli and one S. boydii isolated from feces samples collected from children under 5 years of age with diarrhea in Lima, Peru were inoculated onto Mueller-Hinton plates containing increasing ...
  • Mucopolysaccharidosis type II: identification of 30 novel mutations among Latin American patients 
    Brusius-Facchin, A. C.; Schwartz, I. V. D.; Zimmer, C.; Ribeiro, M. G.; Acosta, A. X.; Horovitz, D.; Monlleo, I. L.; Fontes, M. I. B.; Fett-Conte, A.; Sobrinho, R. P. Oliveira; Duarte, A. R.; Boy, R.; Mabe, P.; Ascurra, M.; de Michelena, M.; Tylee, K. L.; Besley, G. T. N.; Garreton, M. C. V.; Giugliani, R.; Leistner-Segal, S. (Elsevier, 2014)
    In this study, 103 unrelated South-American patients with mucopolysaccharidosis type II (MPS II) were investigated aiming at the identification of iduronate-2-sulfatase (IDS) disease causing mutations and the possibility ...
  • Multicenter study of anidulafungin and micafungin MIC distributions and epidemiological cutoff values for eight candida species and the CLSI M27-A3 broth microdilution method 
    Pfaller, M.A.; Espinel-Ingroff, A.; Bustamante Rufino, Ana Beatriz; Canton, E.; Diekema, D.J.; Fothergill, A.; Fuller, J.; Gonzalez, G.M.; Guarro, J.; Lass-Flörl, C.; Lockhart, S.R.; Martin-Mazuelos, E.; Meis, J.F.; Ostrosky-Zeichner, L.; Pelaez, T.; St-Germain, G.; Turnidge, J. (American Society for Microbiology, 2014)
    Since epidemiological cutoff values (ECVs) using CLSI MICs from multiple laboratories are not available for Candida spp. and the echinocandins, we established ECVs for anidulafungin and micafungin on the basis of wild-type ...
  • A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance 
    Sheen Cortavarria, Patricia; Requena, David; Gushiken, Eduardo; Gilman, Robert Hugh; Antiparra, Ricardo; Lucero, Bryan; Lizárraga, Pilar; Cieza, Basilio; Roncal, Elisa; Grandjean, Louis; Pain, Arnab; McNerney, Ruth; Clark, Taane G.; Moore, David Alexander James; Zimic-Peralta, Mirko Juan (BioMed Central, 2017)
    BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
  • Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study 
    García Castaño, A.; Pérez de Nanclares, G.; Madariaga, L.; Aguirre, M.; Chocron, S.; Madrid, A.; Lafita Tejedor, F.J.; Gil Campos, M.; Sánchez del Pozo, J.; Ruiz Cano, R.; Espino, M.; Gomez Vida, J.M.; Santos, F.; García Nieto, V.M.; Loza, R.; Rodríguez, L.M.; Hidalgo Barquero, E.; Printza, N.; Camacho, J.A.; Castaño, L.; Ariceta, G.; RenalTube Group (Springer, 2015)
    Molecular diagnosis is a useful diagnostic tool in primary nephrogenic diabetes insipidus (NDI), an inherited disease characterized by renal inability to concentrate urine. The AVPR2 and AQP2 genes were screened for mutations ...
  • Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations 
    Kehdy, F.S.G.; Gouveia, M.H.; Machado, M.; Magalhães, W.C.S.; Horimoto, A.R.; Horta, B.L.; Moreira, R.G.; Leal, T.P.; Scliar, M.O.; Soares-Souza, G.B.; Rodrigues-Soares, F.; Araújo, G.S.; Zamudio, R.; Sant Anna, H.P.; Santos, H.C.; Duarte, N.E.; Fiaccone, R.L.; Figueiredo, C.A.; Silva, T.M.; Costa, G.N.O.; Beleza, S.; Berg, D.E.; Cabrera, L.; Debortoli, G.; Duarte, D.; Ghirotto, S.; Gilman, Robert Hugh; Gonçalves, V.F.; Marrero, A.R.; Muniz, Y.C.; Weissensteiner, H.; Yeager, M.; Rodrigues, L.C.; Barreto, M.L.; Lima-Costa, M.F.; Pereira, A.C.; Rodrigues, M.R.; Tarazona-Santos, E. (National Academy of Sciences, 2015)
    While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture.We present the results of the EPIGEN Brazil Initiative, the most ...
  • Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages 
    Phelan, Jody-E.; Coll, Francesc; Bergval, Indra; Anthony, Richard-M.; Warren, Rob; Sampson, Samantha-L.; Gey-van-Pittius, Nicolaas-C.; Glynn, Judith-R.; Crampin, Amelia-C.; Alves, Adriana; Bessa, Theolis-Barbosa; Campino, Susana; Dheda, Keertan; Grandjean, Louis; Hasan, Rumina; Hasan, Zahra; Miranda, Anabela; Moore, David Alexander James; Panaiotov, Stefan; Perdigao, Joao; Portugal, Isabel; Sheen Cortavarria, Patricia; de-Oliveira-Sousa, Erivelton; Streicher, Elizabeth-M.; van-Helden, Paul-D.; Viveiros, Miguel; Hibberd, Martin-L.; Pain, Arnab; McNerney, Ruth; Clark, Taane-G. (BioMed Central, 2016)
    BACKGROUND: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families ...
  • Treponema pallidum pallidum Genotypes and Macrolide Resistance Status in Syphilitic Lesions among Patients at 2 Sexually Transmitted Infection Clinics in Lima, Peru 
    Flores, Juan-Antonio; Vargas Rivera, Silver Keith; León Sandoval, Segundo Ramos; Perez, Danny-Giancarlo; Ramos, Lourdes-Beatriz; Chow, Jeremy; Konda, Kelika-Anne; Calvo, Gino-Mauricio; Salvatierra, Hector-J.; Klausner, Jeffrey-D.; Caceres Palacios, Carlos Fernando (Wolters Kluwer Health, 2016)
    We report the circulating genotypes and the frequency of macrolide-resistance patterns among Treponema pallidum pallidum DNA isolated from syphilitic lesions from patients who attended 2 sexual health clinics in Lima, Peru. ...

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