Listar por tema "Mutations"

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  • Molecular modeling studies demonstrate key mutations that could affect the ligand recognition by influenza AH1N1 neuraminidase 
    Ramirez-Salinas, Gema L.; Garcia-Machorro, J.; Quiliano, Miguel; Zimic-Peralta, Mirko Juan; Briz, Veronica; Rojas-Hernandez, Saul; Correa-Basurto, J. (Springer, 2015)
    The goal of this study was to identify neuraminidase (NA) residue mutants from human influenza AH1N1 using sequences from 1918 to 2012. Multiple alignment studies of complete NA sequences (5732) were performed. Subsequently, ...
  • A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance 
    Sheen Cortavarria, Patricia; Requena, David; Gushiken, Eduardo; Gilman, Robert Hugh; Antiparra, Ricardo; Lucero, Bryan; Lizárraga, Pilar; Cieza, Basilio; Roncal, Elisa; Grandjean, Louis; Pain, Arnab; McNerney, Ruth; Clark, Taane G.; Moore, David Alexander James; Zimic-Peralta, Mirko Juan (BioMed Central, 2017)
    BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
  • Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients 
    Reichmuth, M.L.; Hömke, R.; Zürcher, K.; Sander, P.; Avihingsanon, A.; Collantes, J.; Loiseau, C.; Borrell, S.; Reinhard, M.; Wilkinson, R.J.; Yotebieng, M.; Fenner, L.; Böttger, E.C.; Gagneux, S.; Egger, M.; Keller, P.M.; International epidemiology Databases to Evaluate AIDS (IeDEA) (American Society for Microbiology, 2020)
    Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. ...

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