Universidad Peruana Cayetano Heredia

Listar por tema "Mycobacterium tuberculosis/drug effects/genetics"

Listar por tema "Mycobacterium tuberculosis/drug effects/genetics"

Ordenar por:Orden:Resultados:

  • Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru 
    Grandjean, Louis; Gilman, Robert Hugh; Iwamoto, Tomatada; Köser, Claudio U.; Coronel, Jorge; Zimic-Peralta, Mirko Juan; Török, M. Estee; Ayabina, Diepreye; Kendall, Michelle; Fraser, Christophe; Harris, Simon; Parkhill, Julian; Peacock, Sharon J.; Moore, David Alexander James; Colijn, Caroline (Public Library of Science, 2017)
    BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic ...
  • dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains 
    Moradigaravand, Danesh; Grandjean, Louis; Martinez, Elena; Li, Hao; Zheng, Jun; Coronel, Jorge; Moore, David Alexander James; Torok, M. Estee; Sintchenko, Vitali; Huang, Hairong; Javid, Babak; Parkhill, Julian; Peacock, Sharon-J.; Koser, Claudio-U. (American Society for Microbiology, 2016)
    Para-Aminosalicylic acid (PAS) is a group 4 antituberculosis agent. It targets folate metabolism as shown in Fig. S1 in the supplemental material, which also summarizes the known mechanisms of resistance to this prodrug. ...
  • A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance 
    Sheen Cortavarria, Patricia; Requena, David; Gushiken, Eduardo; Gilman, Robert Hugh; Antiparra, Ricardo; Lucero, Bryan; Lizárraga, Pilar; Cieza, Basilio; Roncal, Elisa; Grandjean, Louis; Pain, Arnab; McNerney, Ruth; Clark, Taane G.; Moore, David Alexander James; Zimic-Peralta, Mirko Juan (BioMed Central, 2017)
    BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
  • Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure 
    Jayakumar, A.; Savic, R. M.; Everett, C. K.; Benator, D.; Alland, D.; Heilig, C. M.; Weiner, M.; Friedrich, S. O.; Martinson, N. A.; Kerrigan, A.; Zamudio Fuertes, Carlos Eduardo; Goldberg, S. V.; Whitworth, W. C.; Davis, J. L.; Nahid, P. (American Society for Microbiology, 2016)
    The Xpert MTB/RIF assay is both sensitive and specific as a diagnostic test. Xpert also reports quantitative output in cycle threshold (CT) values, which may provide a dynamic measure of sputum bacillary burden when used ...

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