Listar por tema "Pyrazinamide"

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  • Clinical research and development of tuberculosis diagnostics: Moving from silos to synergy 
    Nahid, P.; Kim, P.S.; Evans, Carlton Anthony William; Alland, D.; Barer, M.; Diefenbach, J.; Ellner, J.; Hafner, R.; Hamilton, C.D.; Iademarco, M.F.; Ireton, G.; Kimerling, M.E.; Lienhardt, C.; MacKenzie, W.R.; Murray, M.; Perkins, M.D.; Posey, J.E.; Roberts, T.; Sizemore, C.; Stevens, W.S.; Via, L.; Williams, S.D.; Yew, W.W.; Swindells, S. (Oxford University Press, 2012)
    The development, evaluation, and implementation of new and improved diagnostics have been identified as critical needs by human immunodeficiency virus (HIV) and tuberculosis researchers and clinicians alike. These needs ...
  • Metallochaperones are needed for mycobacterium tuberculosis and Escherichia coli nicotinamidase-pyrazinamidase activity 
    Sheen Cortavarria, Patricia; Monsalve, A.; Campos, J.; Huerta, R.; Antiparra, R.; Arteaga, H.; Duran, P.; Bueno, C.; Kirwan, D.E.; Gilman, Robert Hugh; Zimic-Peralta, Mirko Juan (American Society for Microbiology, 2020)
    Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone ...
  • MODS-Wayne, a colorimetric adaptation of the Microscopic-Observation Drug Susceptibility (MODS) assay for detection of mycobacterium tuberculosis pyrazinamide resistance from sputum samples 
    Alcántara, Roberto; Fuentes, Patricia; Antiparra, Ricardo; Santos, Marco; Gilman, Robert Hugh; Kirwan, Daniela E.; Zimic-Peralta, Mirko Juan; Sheen Cortavarria, Patricia (American Society for Microbiology, 2018)
    Although pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) ...
  • A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance 
    Sheen Cortavarria, Patricia; Requena, David; Gushiken, Eduardo; Gilman, Robert Hugh; Antiparra, Ricardo; Lucero, Bryan; Lizárraga, Pilar; Cieza, Basilio; Roncal, Elisa; Grandjean, Louis; Pain, Arnab; McNerney, Ruth; Clark, Taane G.; Moore, David Alexander James; Zimic-Peralta, Mirko Juan (BioMed Central, 2017)
    BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
  • A new approach for pyrazinamide susceptibility testing in mycobacterium tuberculosis 
    Zimic-Peralta, Mirko Juan; Loli, S.; Gilman, Robert Hugh; Gutierrez, Andrés; Fuentes, P.; Cotrina, M.; Kirwan, D.; Sheen Cortavarria, Patricia (Mary Ann Liebert, 2012)
    Background: Pyrazinamide (PZA) is an important drug in the treatment of tuberculosis. Microbiological methods of PZA susceptibility testing are controversial and have low reproducibility. After conversion of PZA into ...
  • Nicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds 
    Rueda, Daniel; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Bueno, Carlos; Santos, Marco; Pando-Robles, Victoria; Batista, Cesar V.; Zimic-Peralta, Mirko Juan (Elsevier, 2014)
    Recombinant wild-pyrazinamidase from H37Rv Mycobacterium tuberculosis was analyzed by gel electrophoresis under differential reducing conditions to evaluate its quaternary structure. PZAse was fractionated by size exclusion ...
  • Potentiometric method for resistance's measurement of pyrazinamide in mycobacterium tuberculosis 
    Furukawa, Roberto; Rueda, Daniel; Zimic-Peralta, Mirko Juan; IEEE Engineering in Medicine and Biology Society (EMBS); IEEE Robotic and Automation Society (RAS) (IEEE , 2014)
    An experimental research of the drug pyrazinamide is analyzed and tested with potentiometric method. By understanding the biomechatronic system, consisted of a mechanism of action of the drug Pyrazinamide in a biological ...
  • A quantitative adaptation of the Wayne test for pyrazinamide resistance 
    Meinzen, Christopher; Proano, Alvaro; Gilman, Robert Hugh; Caviedes, Luz; Coronel, Jorge; Zimic-Peralta, Mirko Juan; Sheen Cortavarria, Patricia (Elsevier, 2016)
    BACKGROUND: Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and ...

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