Listar por tema "erythropoietin"

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  • Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge's disease) 
    Sharma, S.; Gralla, J.; Ordonez, J. G.; Hurtado, M. E.; Swenson, E. R.; Schoene, R. B.; Kelly, J. P.; Callacondo, D.; Rivard, C.; Roncal-Jimenez, C.; Sirota, J.; Fuquay, R.; Jackson, B. P.; Swenson, K. E.; Johnson, R. J.; Hurtado, A.; Escudero, E. (Elsevier, 2017)
    Patients suffering from chronic mountain sickness (CMS) have excessive erythrocytosis. Low level cobalt toxicity as a likely contributor has been demonstrated in some subjects. We performed a randomized, placebo controlled ...
  • Adaptation of iron requirement to hypoxic conditions at high altitude 
    Gassmann, Max; Muckenthaler, Martina U. (American Physiological Society, 2015)
    Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most important aspects for mountaineers ascending to high altitude. Accordingly, most reviews emphasize mechanisms that cope with reduced ...
  • Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru 
    Painschab, M.S.; Malpartida, G.E.; Dávila-Roman, V.G.; Gilman, Robert Hugh; Kolb, T.M.; León-Velarde, Fabiola; Miranda, J. Jaime; Checkley, W. (Mary Ann Liebert, 2015)
    Long-term residence at high altitude is associated with the development of chronic mountain sickness (CMS), which is characterized by excessive erythrocytosis (EE). EE occurs under chronic hypoxia, and a strongly selected ...
  • Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness 
    Villafuerte, Francisco C.; Macarlupú, José Luis; Anza-Ramírez, Cecilia; Corrales-Melgar, Daniela; Vizcardo-Galindo, Gustavo; Corante, Noemí; León-Velarde, Fabiola (American Physiological Society, 2014)
    Excessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop ...
  • Early versus delayed erythropoietin for the anaemia of end-stage kidney disease 
    Coronado Daza, J.; Martí-Carvajal, A.J.; Ariza García, A.; Rodelo Ceballos, J.; Yomayusa González, N.; Páez-Canro, C.; Loza Munarriz, Cesar Antonio; Urrútia, G. (Wiley, 2015)
    Background: Anaemia is a common complication in people with chronic kidney disease (CKD) and mainly develops as a consequence of relative erythropoietin (EPO) deficiency. Anaemia develops early in the course of disease and ...
  • Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice 
    Singh, Rashim Pal; Grinenko, Tatyana; Ramasz, Beáta; Franke, Kristin; Lesche, Mathias; Dahl, Andreas; Gassmann, Max; Chavakis, Triantafyllos; Henry, Ian; Wielockx, Ben (Elsevier, 2018)
    The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization ...
  • High altitude renal syndrome (HARS) 
    Hurtado Arestegui, A.; Fuquay, R.; Sirota, J.; Swenson, E.R.; Schoene, R.B.; Jefferson, J.A.; Chen, W.; Yu, X.-Q.; Kelly, J.P.; Johnson, R.J.; Escudero, E. (American Society of Nephrolog, 2011)
    More than 140 million people live permanently at high altitude (>2400 m) under hypoxic conditions that challenge basic physiology. Here we present a short historical review of the populating of these regions and of evidence ...
  • High-Altitude Hypoxia Decreases Plasma Erythropoietin Soluble Receptor Concentration in Lowlanders 
    Vizcardo-Galindo, G.; León-Velarde, Fabiola; Villafuerte, Francisco C. (Mary Ann Liebert, 2020)
    Background: The soluble form of the erythropoietin (Epo) receptor (sEpoR) is an endogenous antagonist of Epo. Decreasing plasma sEpoR increases free Epo, thereby increasing the availability of the hormone. In humans, ...
  • Hypercapnic ventilatory response is decreased in a mouse model of excessive erythrocytosis 
    Laouafa, Sofien; Elliot-Portal, Elizabeth; Revollo, Susana; Schneider-Gasser, Edith-M.; Joseph, Vincent; Voituron, Nicolas; Gassmann, Max; Soliz, Jorge (American Physiological Society, 2016)
    The impact of cerebral erythropoietin (Epo) in the regulation of the hypercapnic ventilatory response (HcVR) is controversial. While we reported that cerebral Epo does not affect the central chemosensitivity in C57Bl6 ...
  • Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice 
    Díaz, Víctor; Gammella, Elena; Recalcati, Stefania; Santambrogio, Paolo; Naldi, Arianne Monge; Vogel, Johannes; Gassmann, Max; Cairo, Gaetano (Wiley, 2013)
    The liver-derived peptide hepcidin controls the balance between iron demand and iron supply. By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores. ...
  • Reduced insulin sensitivity as a marker for acute mountain sickness? 
    Spliethoff, Kerstin; Meier, Daniela; Aeberli, Isabelle; Gassmann, Max; Langhans, Wolfgang; Maggiorini, Marco; Lutz, Thomas .A.; Goetze, Oliver (Mary Ann Liebert, 2013)
    The diabetogenic side effects of dexamethasone should therefore be considered for AMS treatment. To examine whether reduced insulin sensitivity is predictive of AMS and how it is affected by dexamethasone at high altitude, ...
  • Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation 
    Dey, Soumyadeep; Cui, Zhenzhong; Gavrilova, Oksana; Zhang, Xiaojie; Gassmann, Max; Noguchi, Constance T. (American Society for Clinical Investigation, 2020)
    The blood hormone erythropoietin (EPO), upon binding to its receptor (EpoR), modulates high-fat diet-induced (HFO-induced) obesity in mice, improves glucose tolerance, and prevents white adipose tissue inflammation. ...

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