Listar por tema "gene expression"

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  • The association of microbial activity with Fe, S and trace element distribution in sediment cores within a natural wetland polluted by acid mine drainage 
    Aguinaga Vargas, Oscar Enrique; Wakelin, James F. T.; White, Keith N.; Dean, Andrew P.; Pittman, Jon K. (Elsevier, 2019)
    Natural recovery and remediation of acid mine drainage (AMD) reduces the generation of acidity and transport of trace elements in the runoff. A natural wetland that receives and remediates AMD from an abandoned copper mine ...
  • Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis 
    Leon-Janampa, Nancy; Liendo, Ruddy; Gilman, Robert Hugh; Padilla, Carlos; García Lescano, Héctor Hugo; Gonzales, Armando; Sheen Cortavarria, Patricia; Pajuelo Travezaño, Monica Jhenny; Zimic-Peralta, Mirko Juan; Cysticercosis Working Group in Peru (Elsevier, 2019)
    Porcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, ...
  • Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains 
    Reis-Cunha, J.L.; Rodrigues-Luiz, G.F.; Valdivia, H.O.; Baptista, R.P.; Mendes, T.A.O.; Loss de Morais, G.; Guedes, R.; Macedo, A.M.; Bern, C.; Gilman, Robert Hugh; Talavera Lopez, C.; Andersson, B.; Vasconcelos, A.T.; Bartholomeu, D.C. (BioMed Central, 2015)
    Background: Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. CL Brener, the reference strain of the T. cruzi genome project, is a hybrid ...
  • Circulating T cell-monocyte complexes are markers of immune perturbations. 
    Burel, Julie G.; Pomaznoy, Mikhail; Lindestam Arlehamn, Cecilia S.; Weiskopf, Daniela; da Silva Antunes, Ricardo; Jung, Yunmin; Babor, Mariana; Schulten, Veronique; Seumois, Gregory; Greenbaum, Jason A.; Premawansa, Sunil; Premawansa, Gayani; Wijewickrama, Ananda; Vidanagama, Dhammika; Gunasena, Bandu; Tippalagama, Rashmi; deSilva, Aruna D.; Gilman, Robert Hugh; Saito, Mayuko; Taplitz, Randy; Ley, Klaus; Vijayanand, Pandurangan; Sette, Alessandro; Peters, Bjoern (eLife Sciences Publications, 2019)
    Our results highlight for the first time that a significant proportion of cell doublets in flow cytometry, previously believed to be the result of technical artifacts and thus ignored in data acquisition and analysis, are ...
  • Effect of lepidium meyenii (Maca) on spatial memory and brain oxidative damage of ovariectomised-rats exposed to mobile phone 
    Marín-Tello, C.; Villafana-Medina, H.; Malpartida-Tello, V.; Sánchez-Marín, C.; Castañeda-Marín, E.; Vásquez-Kool, J.; Aliaga-Arauco, J. (School of Pharmaceutical and Food Sciences, University of Antioquia, 2021)
    Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food ...
  • Ex Vivo Innate Immune Cytokine Signature of Enhanced Risk of Relapsing Brucellosis 
    Feldman, Kristyn E.; Loriaux, Paul M.; Saito, Mayuko; Tuero Ochoa, Iskra; Villaverde, Homarh; Siva, Tenaya; Gotuzzo Herencia, José Eduardo; Gilman, Robert Hugh; Hoffmann, Alexander; Vinetz, Joseph Michael (Public Library of Science, 2013)
    Brucellosis, a zoonotic infection caused by one of the Gram-negative intracellular bacteria of the Brucella genus, is an ongoing public health problem in Perú. While most patients who receive standard antibiotic treatment ...
  • Expression of sialic acids and other nonulosonic acids in Leptospira 
    Ricaldi, J.N.; Matthias, M.A.; Vinetz, Joseph Michael; Lewis, A.L. (BioMed Central, 2012)
    Background: Sialic acids are negatively charged nine carbon backbone sugars expressed on mammalian cell surfaces. Sialic acids are part of a larger family of nonulosonic acid (NulO) molecules that includes pseudaminic and ...
  • A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia 
    Adhikari, K.; Mendoza-Revilla, J.; Sohail, A.; Fuentes-Guajardo, M.; Lampert, J.; Chacón-Duque, J.C.; Hurtado, M.; Villegas, V.; Granja, V.; Acuña-Alonzo, V.; Jaramillo, C.; Arias, W.; Lozano, R.B.; Everardo, P.; Gómez-Valdés, J.; Villamil-Ramírez, H.; Silva de Cerqueira, C.C.; Hunemeier, T.; Ramallo, V.; Schuler-Faccini, L.; Salzano, F.M.; Gonzalez-José, R.; Bortolini, M.-C.; Canizales-Quinteros, S.; Gallo López-Aliaga, Carla Maria; Poletti, G.; Bedoya, G.; Rothhammer, F.; Tobin, D.J.; Fumagalli, M.; Balding, D.; Ruiz-Linares, A. (Springer Nature, 2019)
    We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation ...
  • LINE-1 and EPAS1 DNA methylation associations with high-altitude exposure 
    Childebayeva, Ainash; Jones, Tamara R.; Goodrich, Jaclyn M.; León-Velarde, Fabiola; Rivera Chira, Maria Concepcion; Kiyamu Tsuchiya, Melisa; Brutsaert, Tom D.; Dolinoy, Dana C.; Bigham, Abigail W. (Taylor and Francis, 2019)
    Recent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain ...
  • Mechanisms of liver fibrosis associated with experimental fasciola hepatica infection: Roles of Fas2 proteinase and hepatic stellate cell activation 
    Marcos, L.A.; Terashima, A.; Yi, P.; Andrade, R.; Cubero, F.J.; Albanis, E.; Gotuzzo Herencia, José Eduardo; Espinoza, J.R.; Friedman, S.L. (American Society of Parasitologists, 2011)
    We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed ...
  • Neurogenetics in Peru: clinical, scientific and ethical perspectives 
    Cornejo-Olivas, M.; Espinoza Huertas, Keren Antonieta; Velit-Salazar, M.R.; Veliz-Otani, D.; Tirado-Hurtado, I.; Inca-Martinez, M.; Silva-Paredes, G.; Milla-Neyra, K.; Marca, V.; Ortega, O.; Mazzetti, P. (Springer, 2015)
    Neurogenetics, the science that studies the genetic basis of the development and function of the nervous system, is a discipline of recent development in Peru, an emerging Latin American country. Herein, we review the ...
  • Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates 
    Parveen, N.; Fernandez, M.C.; Haynes, A.M.; Zhang, R.-L.; Godornes, B.C.; Centurion-Lara, A.; Giacani, L. (Elsevier, 2019)
    Background: Syphilis is resurgent in many developed countries and still prevalent in developing nations. Current and future control campaigns would benefit from the development of a vaccine, but although promising vaccine ...
  • Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans 
    Lehmann, Jason S.; Fouts, Derrick E.; Haft, Daniel H.; Cannella, Anthony P.; Ricaldi, Jessica N.; Brinkac, Lauren; Harkins, Derek; Durkin, Scott; Sanka, Ravi; Sutton, Granger; Moreno, Angelo; Vinetz, Joseph Michael; Matthias, Michael A. (Public Library of Science, 2013)
    Leptospirosis is a globally important, neglected zoonotic infection caused by spirochetes of the genus Leptospira. Since genetic transformation remains technically limited for pathogenic Leptospira, a systems biology ...
  • Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat 
    Giacani, L.; Brandt, S.L.; Ke, W.; Reid, T.B.; Molini, B.J.; Iverson-Cabral, S.; Ciccarese, G.; Drago, F.; Lukehart, S.A.; Centurion-Lara, A. (American Society for Microbiology, 2015)
    An effective mechanism for introduction of phenotypic diversity within a bacterial population exploits changes in the length of repetitive DNA elements located within gene promoters. This phenomenon, known as phase variation, ...
  • Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum 
    Haynes, Austin M.; Fernandez, Mark; Romeis, Emily; Mitjà, Oriol; Konda, Kelika A.; Vargas Rivera, Silver Keith; Eguiluz, Maria; Caceres Palacios, Carlos Fernando; Klausner, Jeffrey D.; Giacani, Lorenzo (Public Library of Science, 2021)
    BACKGROUND: An effective syphilis vaccine should elicit antibodies to Treponema pallidum subsp. pallidum (T. p. pallidum) surface antigens to induce pathogen clearance through opsonophagocytosis. Although the combination ...
  • Whole-Genome sequencing uncovers the genetic basis of chronic mountain sickness in andean highlanders 
    Zhou, Dan; Udpa, Nitin; Ronen, Roy; Stobdan, Tsering; Liang, Junbin; Appenzeller, Otto; Zhao, Huiwen W.; Yin, Yi; Du, Yuanping; Guo, Lixia; Cao, Rui.; Wang, Yu; Jin, Xin; Huang, Chen; Jia, Wenlong; Cao, Dandan; Guo, Guangwu; Gamboa, Jorge L.; Villafuerte, Francisco C.; Callacondo, David; Xue, Jin; Liu, Siqi; Frazer, Kelly A.; Li, Yingrui; Bafna, Vineet; Haddad, Gabriel G. (Elsevier, 2013)
    The hypoxic conditions at high altitudes present a challenge for survival, causing pressure for adaptation. Interestingly, many highaltitude denizens (particularly in the Andes) are maladapted, with a condition known as ...

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