Listar por tema "in vitro study"

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  • Activity-guided isolation of antileishmanial compounds from Piper hispidum 
    Ruiz, C.; Haddad, M.; Alban, J.; Bourdy, G.; Reategui, R.; Castillo Pareja, Denis Helan; Sauvain, Michel Henri Auguste; Deharo, E.; Estevez, Y.; Arévalo Zelada, Jorge Luis; Rojas, R. (Elsevier, 2011)
    The bioassay-guided purification of the ethanolic extract from the leaves of Piper hispidum led to the isolation of one new amide, N-2-(3′,4′, 5′-trimethoxyphenyl)ethyl-2-hydroxybenzamide (1) as well as two known chalcones ...
  • Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy 
    Moens, B.; Decanine, D.; Menezes, S.M.; Khouri, R.; Silva-Santos, G.; Lopez, G.; Alvarez, C.; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; de Almeida Kruschewsky, R.; Galvão-Castro, B.; Vandamme, A.-M.; van Weyenbergh, J. (Public Library of Science, 2012)
    Background: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar ...
  • CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis 
    Menezes, Soraya Maria; Decanine, Daniele; Brassat, David; Khouri, Ricardo; Schnitman, Saul V.; Kruschewsky, Ramon; López, Giovanni; Alvarez, Carolina; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Vandamme, Anne-Mieke; Galvão-Castro, Bernardo; Liblau, Roland; Weyenbergh, Johan Van (BioMed Central, 2014)
    Background: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no ...
  • Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony 
    Adaui, V.; Schnorbusch, K.; Zimic-Peralta, Mirko Juan; Gutirrez, A.; Decuypere, S.; Vanaerschot, M.; De Doncker, S.; Maes, I.; Llanos Cuentas, Elmer Alejandro; Chappuis, F.; Arvalo, J.; Dujardin, J.-C. (Crambridge University Press, 2011)
    Introduction. Evaluation of Leishmania drug susceptibility depends on in vitro SbV susceptibility assays, which are labour-intensive and may give a biased view of the true parasite resistance. Molecular markers are urgently ...
  • Correlation of susceptibility of Cryptococcus neoformans to amphotericin B with clinical outcome 
    Larsen, R.A.; Bauer, M.; Pitisuttithum, P.; Sanchez, A.; Tansuphaswadikul, S.; Wuthiekanun, V.; Peacock, S.J.; Simpson, A.J.H.; Fothergill, A.W.; Rinaldi, M.G.; Bustamante Rufino, Ana Beatriz; Thomas, A.M.; Altomstone, R.; Day, N.P.J.; White, N.J. (American Society for Microbiology, 2011)
    Testing of Cryptococcus neoformans for susceptibility to antifungal drugs by standard microtiter methods has not been shown to correlate with clinical outcomes. This report describes a modified quantitative broth macrodilution ...
  • Endogenous α-calcitonin-gene-related peptide promotes exercise-induced, physiological heart hypertrophy in mice 
    Schuler, B.; Rieger, G.; Gubser, M.; Arras, M.; Gianella, M.; Vogel, O.; Jirkof, P.; Cesarovic, N.; Klohs, J.; Jakob, P.; Brock, M.; Gorr, T.A.; Baum, O.; Hoppeler, H.; Samillan-Soto, V.; Gassmann, M.; Fischer, J.A.; Born, W.; Vogel, J. (Wiley, 2014)
    Aim: It is unknown how the heart distinguishes various overloads, such as exercise or hypertension, causing either physiological or pathological hypertrophy. We hypothesize that alpha-calcitonin-gene-related peptide (αCGRP), ...
  • In vitro development and analysis of escherichia coli and shigella boydii azithromycin-resistant mutants 
    Gomes, Claudia; Pons, Maria J.; Magallon-Tejada, Ariel; Durand Vara, David Percy; Lluque, Angela; Mosquito, Susan; Riveros Ramirez, Maribel Denise; Mercado, Erik; Prada, Ana; Ochoa Woodell, Theresa Jean; Ruiz, Joaquim (Mary Ann Liebert, 2013)
    Three clinical isolates of E. coli and one S. boydii isolated from feces samples collected from children under 5 years of age with diarrhea in Lima, Peru were inoculated onto Mueller-Hinton plates containing increasing ...
  • Lack of molecular correlates of Plasmodium vivax ookinete development 
    Bounkeua, V.; Li, F.; Chuquiyauri, R.; Abeles, S.R.; McClean, C.M.; Neyra, V.; Llanos Cuentas, Elmer Alejandro; Yori, P.P.; Vinetz, Joseph Michael (American Society of Tropical Medicine and Hygiene, 2011)
    Previous studies of Plasmodium vivax transmission to Anopheles spp. mosquitoes have not been able to predict mosquito infectivity on the basis of microscopic or molecular quantification of parasites (total parasites in the ...
  • Mechanisms of liver fibrosis associated with experimental fasciola hepatica infection: Roles of Fas2 proteinase and hepatic stellate cell activation 
    Marcos, L.A.; Terashima, A.; Yi, P.; Andrade, R.; Cubero, F.J.; Albanis, E.; Gotuzzo Herencia, José Eduardo; Espinoza, J.R.; Friedman, S.L. (American Society of Parasitologists, 2011)
    We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed ...
  • New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae) 
    Bertani, S.; Houël, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. (Elsevier, 2012)
    Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown ...
  • Relevance of Hemin for in vitro Differentiation of Trypanosoma cruzi 
    Arévalo Zelada, Jorge Luis; Panebra, A.; Cruz, Carlos Santa (Wiley, 1985)
    Simple culture conditions that allow good growth and high yields of trypomastigotes are described. The proportion of metacyclic trypomastigotes increases with the concentration of hemin in the culture medium, reaching a ...
  • Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase 
    Sheen Cortavarria, Patricia; Ferrer, P.; Gilman, Robert Hugh; Christiansen, G.; Moreno-Román, P.; Gutiérrez, A.H.; Sotelo, J.; Evangelista, W.; Fuentes, P.; Rueda, D.; Flores, M.; Olivera, P.; Solis, J.; Pesaresi, A.; Lamba, D.; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2012)
    Pyrazinamidase of Mycobacterium tuberculosis catalyzes the conversion of pyrazinamide to the active molecule pyrazinoic acid. Reduction of pyrazinamidase activity results in a level of pyrazinamide resistance. Previous ...
  • Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines 
    Moens, B.; Pannecouque, C.; Lápez, G.; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Khouri, R.; Bittencourt, A.; Farré, L.; Galvão-Castro, B.; Vandamme, A.-M.; Van Weyenbergh, J. (BioMed Central, 2012)
    Background: IFN- contributes extensively to host immune response upon viral infection through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although extensively documented in various types ...

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