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Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis

Ravis, William R.; Llanos Cuentas, Elmer Alejandro; Sosa, Nestor; Kreishman-Deitrick, Mara; Kopydlowski, Karen M.; Nielsen, Carl; Smith, Kristen S.; Smith, Philip L.; Ransom, Janet H.; Lin, Yuh-Jing; Grogl, Max (American Society for Microbiology, 2013)

This study evaluated the pharmacokinetics of topical creams containing 15% paromomycin (“paromomycin alone”) and 15% paromomycin plus 0.5% gentamicin (WR 279,396) in patients with cutaneous leishmaniasis. The investigational ...