Listar por tema "upregulation"

Mostrando ítems 1-11 de 11

Are increased Foxp3+ regulatory T cells responsible for immunosuppression during HTLV-1 infection? Case reports and review of the literature

Barros, N.; Woll, F.; Watanabe, L.; Montes Delgado, Martin (BMJ Publishing Group, 2012)

Research of human T lymphotropic virus type I (HTLV-1)-associated diseases is mostly focused on inflammatory and lymphoproliferative disorders. However, the immunosuppressive consequences of HTLV-1 infection are frequently ...
Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy

Moens, B.; Decanine, D.; Menezes, S.M.; Khouri, R.; Silva-Santos, G.; Lopez, G.; Alvarez, C.; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; de Almeida Kruschewsky, R.; Galvão-Castro, B.; Vandamme, A.-M.; van Weyenbergh, J. (Public Library of Science, 2012)

Background: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar ...
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

Menezes, Soraya Maria; Decanine, Daniele; Brassat, David; Khouri, Ricardo; Schnitman, Saul V.; Kruschewsky, Ramon; López, Giovanni; Alvarez, Carolina; Talledo Albujar, Michael John; Gotuzzo Herencia, José Eduardo; Vandamme, Anne-Mieke; Galvão-Castro, Bernardo; Liblau, Roland; Weyenbergh, Johan Van (BioMed Central, 2014)

Background: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no ...
Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony

Adaui, V.; Schnorbusch, K.; Zimic-Peralta, Mirko Juan; Gutirrez, A.; Decuypere, S.; Vanaerschot, M.; De Doncker, S.; Maes, I.; Llanos Cuentas, Elmer Alejandro; Chappuis, F.; Arvalo, J.; Dujardin, J.-C. (Crambridge University Press, 2011)

Introduction. Evaluation of Leishmania drug susceptibility depends on in vitro SbV susceptibility assays, which are labour-intensive and may give a biased view of the true parasite resistance. Molecular markers are urgently ...
Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection

LaMonte, G.M.; Orjuela-Sanchez, P.; Calla Choque, Jaeson Santos; Wang, L.T.; Li, S.; Swann, J.; Cowell, A.N.; Zou, B.Y.; Abdel-Haleem Mohamed, A.M.; Villa Galarce, Z.H.; Moreno, M.; Tong Rios, C.; Vinetz, Joseph Michael; Lewis, N.; Winzeler, E.A. (Springer Nature, 2019)

The exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal ...
Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis

Sathyamoorthy, T.; Sandhu, G.; Tezera, L.B.; Thomas, R.; Singhania, A.; Woelk, C.H.; Dimitrov, B.D.; Agranoff, D.; Evans, Carlton Anthony William; Friedland, J.S.; Elkington, P.T. (Public Library of Science, 2015)

Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as ...
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice

Díaz, Víctor; Gammella, Elena; Recalcati, Stefania; Santambrogio, Paolo; Naldi, Arianne Monge; Vogel, Johannes; Gassmann, Max; Cairo, Gaetano (Wiley, 2013)

The liver-derived peptide hepcidin controls the balance between iron demand and iron supply. By inhibiting the iron export activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores. ...
Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum

Muñoz-Atienza, E.; Távara, C.; Díaz-Rosales, P.; Llanco, L.; Serrano Martinez, Marcos Enrique; Tafalla, C. (Elsevier, 2018)

Flavobacterium psychrophilum is the etiological agent of bacterial cold water disease (BCWD), also referred to as rainbow trout fry syndrome (RTFS), a disease with great economic impact in salmonid aquaculture. Despite ...
Mechanisms of liver fibrosis associated with experimental fasciola hepatica infection: Roles of Fas2 proteinase and hepatic stellate cell activation

Marcos, L.A.; Terashima, A.; Yi, P.; Andrade, R.; Cubero, F.J.; Albanis, E.; Gotuzzo Herencia, José Eduardo; Espinoza, J.R.; Friedman, S.L. (American Society of Parasitologists, 2011)

We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed ...
Multilaboratory study of epidemiological cutoff values for detection of resistance in eight Candida species to fluconazole, posaconazole, and voriconazole

Espinel-Ingroff, A.; Pfaller, M.A.; Bustamante Rufino, Ana Beatriz; Canton, E.; Fothergill, A.; Fuller, J.; Gonzalez, G.M.; Lass-Flörl, C.; Lockhart, S.R.; Martin-Mazuelos, E.; Meis, J.F.; Melhem, M.S.C.; Ostrosky-Zeichner, L.; Pelaez, T.; Szeszs, M.W.; St-Germain, G.; Bonfietti, L.X.; Guarro, J.; Turnidge, J. (American Society for Microbiology, 2014)

Although epidemiological cutoff values (ECVs) have been established for Candida spp. and the triazoles, they are based on MIC data from a single laboratory. We have established ECVs for eight Candida species and fluconazole, ...
Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways

Siques, Patricia; Brito, Julio; Naveas, Nelson; Pulido, Ruth; De La Cruz, Juan José; Mamani, Maribel; León-Velarde, Fabiola (Mary Ann Liebert, 2014)

Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways. High Alt Med Biol 15:388-395, 2014. - Lipid metabolism under chronic hypoxia (CH) has not received equal attention ...

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