Publicación: Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population
| dc.contributor.author | Taype, C.A. | |
| dc.contributor.author | Castro, J.C. | |
| dc.contributor.author | Accinelli, R.A. | |
| dc.contributor.author | Herrera-Velit, P. | |
| dc.contributor.author | Shaw, M.A. | |
| dc.contributor.author | Espinoza, J.R. | |
| dc.date.accessioned | 2026-05-01T06:26:13Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P = 0.02 and 0.03 respectively). INT4-D543N-3′UTR haplotypes showed an association with pulmonary TB (P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form. © 2006 Elsevier B.V. All rights reserved. | en_US |
| dc.description.sponsorship | This study was supported by Proyecto Vigía MINSA/USAID, Lima; Premio Anual de Medicina Francisco Tejada y Semíramis Reátegui (Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, UPCH), Lima; Fundación Instituto Hipólito Unanue, Lima and Consejo Nacional de Ciencia y Tecnología (CONCYTEC), Lima-Perú. CT received support from CONCYETC, the Agreement between Consortium of Francophones Universities of Belgium (CIUF) and UPCH, and the Fundación Cristina e Ismael Cobián (Facultad de Ciencias y Filosofía Alberto Cazorla Tálleri, UPCH). | es_PE |
| dc.identifier.doi | https://doi.org/10.1016/j.meegid.2006.01.002 | |
| dc.identifier.scopus | 2-s2.0-33745374953 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/19447 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | urn:issn:1567-1348 | |
| dc.relation.ispartofseries | Infection, Genetics and Evolution | |
| dc.relation.issn | 1567-1348 | |
| dc.rights | http://purl.org/coar/access_right/c_abf2 | |
| dc.subject | Allelic association | en_US |
| dc.subject | Miliary | en_US |
| dc.subject | Pleural | en_US |
| dc.subject | Pulmonary | en_US |
| dc.subject | SLC11A1 | en_US |
| dc.subject | Tuberculosis | en_US |
| dc.title | Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population | en_US |
| dc.type | https://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type.local | Artículo de revista | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication |