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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of

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dc.contributor.authorSempou, Emily
dc.contributor.authorBiasini, Emiliano
dc.contributor.authorPinzon-Olejua, Alejandro
dc.contributor.authorHarris, David-A.
dc.contributor.authorMálaga Trillo, George Edward
dc.date.accessioned2026-04-28T22:49:55Z
dc.date.issued2016
dc.description.abstractBACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control cell-cell adhesion via a tyrosine phosphorylation-dependent mechanism. RESULTS: Here we report that the Src family kinases (SFKs) Fyn and Yes act downstream of PrP-1 to prevent the endocytosis and degradation ofen_US
dc.identifier.doihttps://doi.org/10.1186/s13024-016-0076-5
dc.identifier.scopus2-s2.0-84958168210
dc.identifier.urihttps://hdl.handle.net/20.500.12866/19237
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofurn:issn:1750-1326
dc.relation.ispartofseriesMolecular Neurodegeneration
dc.relation.issn1750-1326
dc.rightshttp://purl.org/coar/access_right/c_14cb
dc.subjectEndocytosisen_US
dc.subjectAmyloid beta-Peptides/metabolismen_US
dc.subjectAnimalsen_US
dc.subjectbeta Catenin/metabolismen_US
dc.subjectCadherins/metabolismen_US
dc.subjectCell Adhesion/physiologyen_US
dc.subjectCell Membrane/metabolismen_US
dc.subjectNeurons/metabolismen_US
dc.subjectPrions/metabolismen_US
dc.subjectProtein Bindingen_US
dc.subjectProteolysisen_US
dc.subjectSignal Transduction/physiologyen_US
dc.subjectsrc-Family Kinases/metabolismen_US
dc.subjectZebrafish/metabolismen_US
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.01.04
dc.titleActivation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation ofen_US
dc.typeinfo:eu-repo/semantics/article
dc.type.localArtículo de revista
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

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