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In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

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dc.contributor.authorAponte, José C.
dc.contributor.authorCastillo, Denis
dc.contributor.authorEstevez, Yannick
dc.contributor.authorGonzalez, German
dc.contributor.authorArevalo, Jorge
dc.contributor.authorHammond, Gerald B.
dc.contributor.authorSauvain, Michel
dc.date.accessioned2026-05-14T14:27:57Z
dc.date.issued2010
dc.description.abstractThe in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages. © 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doihttps://doi.org/10.1016/j.bmcl.2009.11.033
dc.identifier.scopus2-s2.0-72149098593
dc.identifier.urihttps://hdl.handle.net/20.500.12866/19624
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofurn:issn:0960-894X
dc.relation.ispartofseriesBioorganic and Medicinal Chemistry Letters
dc.relation.issn0960-894X
dc.rightshttp://purl.org/coar/access_right/c_14cb
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnti-Leishmanial drugsen_US
dc.subjectBraziliensisen_US
dc.subjectChalconeen_US
dc.subjectLeishmania amazonensisen_US
dc.subjectPeruvianaen_US
dc.titleIn vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalconesen_US
dc.typehttps://purl.org/coar/resource_type/c_2df8fbb1
dc.type.localArtículo de revista
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

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