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(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids

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dc.contributor.authorVillegas, L.F.
dc.contributor.authorMarçalo, A.
dc.contributor.authorMartin, J.
dc.contributor.authorFernández, I.D.
dc.contributor.authorMaldonado, H.
dc.contributor.authorVaisberg, A.J.
dc.contributor.authorHammond, G.B.
dc.date.accessioned2026-05-01T06:26:25Z
dc.date.issued2001
dc.description.abstractBioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED50 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).en_US
dc.description.sponsorshipNational Cancer Institute, NCI, (R15CA056911)es_PE
dc.identifier.doihttps://doi.org/10.1021/np0102859
dc.identifier.scopus2-s2.0-0034752655
dc.identifier.urihttps://hdl.handle.net/20.500.12866/19462
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofurn:issn:0163-3864
dc.relation.ispartofseriesJournal of Natural Products
dc.relation.issn0163-3864
dc.rightshttp://purl.org/coar/access_right/c_14cb
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEthanolen_US
dc.subjectIsolationen_US
dc.subjectPlantsen_US
dc.subjectRodent modelsen_US
dc.subjectToxicityen_US
dc.title(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoidsen_US
dc.typehttps://purl.org/coar/resource_type/c_2df8fbb1
dc.type.localArtículo de revista
dc.type.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dspace.entity.typePublication

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