Publicación: Energetic metabolism in mouse cerebral cortex during chronic hypoxia
| dc.contributor.author | Ricardo Cáceda | |
| dc.contributor.author | Jorge Gamboa | |
| dc.contributor.author | Jaime Boero | |
| dc.contributor.author | Carlos Monge-C | |
| dc.contributor.author | Alberto Arregui | |
| dc.date.accessioned | 2026-05-14T21:43:32Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | Abstract In order to test the effects of chronic lithium (Li) administration on learning and memory, 21 day old rats were subjected to different degrees of environmental stimulation (enriched condition, EC and impoverished condition, IC) with and without Li for 144 days. Li was administered with food (2.18 mEq/Kg weight/day). Average plasma Li concentration at the end of the experiment was 0.41 ± 0.04 μEq/ml. Both Li treatment and the environmental condition showed an overall significant effect on the cortex/subcortex weight ratio and learning ability index, but not on AChE activity in occipital cortex. A similar pattern of brain Li distribution was observed in both EC-Li and IC-Li, with occipital cortex having the highest levels. Li tissue/protein/plasma ratio was higher in EC than in IC, in all the brain areas studied. Other organs (liver and kidney) did not show EC-IC differences in the tissue/protein/plasma Li ratio. | en_US |
| dc.identifier.doi | https://doi.org/10.1016/s0304-3940(01)01630-5 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/19806 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | urn:issn:0304-3940 | |
| dc.relation.ispartofseries | Neuroscience Letters | |
| dc.relation.issn | 0304-3940 | |
| dc.rights | http://purl.org/coar/access_right/c_14cb | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Mitochondrial Function | en_US |
| dc.subject | Pathology | en_US |
| dc.title | Energetic metabolism in mouse cerebral cortex during chronic hypoxia | en_US |
| dc.type | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.type.local | Artículo de revista | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication |